Effect of Topically Administered Chitosan-<i>N</i>-acetylcysteine on Corneal Wound Healing in a Rabbit Model

Fischak, Corinna; Klaus, Robert; Werkmeister, René M.; Hohenadl, Christine; Prinz, Martin; Schmetterer, Leopold; Garhöfer, Gerhard

doi:10.1155/2017/5192924

Cited by 37 publications

(29 citation statements)

References 31 publications

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“…The results suggested that C-NAC may impart some protective ocular surface properties [195]. Another animal clinical trial indicated that C-NAC had a positive impact on corneal wound healing [196]. Retinol palmitate is known to regulate the proliferation and differentiation of corneal epithelial cells and preserved conjunctival goblet cells.…”

Section: Other Potential Agentsmentioning

confidence: 99%

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

Kuo

Lin

Chien

et al. 2019

JCM

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Dry eye disease (DED) has become common on a global scale in recent years. There is a wide prevalence of DED in different countries based on various ethnicities and environment. DED is a multifactorial ocular disorder. In addition to advanced age and gender, such factors as living at high altitude, smoking, pterygium, prolonged use of consumer electronics or overingesting of caffeine or multivitamins are considered to be the major risk factors of DED. We report the DED epidemiology in Taiwan firstly in this article. According to the pathophysiological factors and changes inthe composition of the tear film in DED, it can be categorized into several subtypes, including lipid anomaly dry eye, aqueous tear deficiency, allergic and toxic dry eye among others. Each subtype has its own cause and disease management; therefore, it is important for ophthalmologists to identify the type through literature review and investigation. The management of DED, relies not only on traditional medications such as artificial tears, gels and ointments, but also newer treatment options such as acupuncture, SYL1001, and nanomedicine therapy. We also conducted a comprehensive literature review including common subtypes and treatment of DED. Clearly, more clinical trials are needed to assess the efficacy and safety of the various treatments and common subtypes of DED.

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Section: Other Potential Agentsmentioning

confidence: 99%

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

Kuo

Lin

Chien

et al. 2019

JCM

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“…[72]. Chitosan-N-acetylcysteine has been approved on the market as eye drops under the name Lacrimera, with increased mucoadhesive properties [73].…”

Section: Chitosanmentioning

confidence: 99%

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Popa¹,

Ghica²,

Dinu-Pîrvu³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.

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“…B. im Rahmen eines kornealen Crosslinkings, erlaubt die UHR-OCT eine genaue Detektion der Wundränder und der Wundtiefe und damit eine präzise Vermessung der Größe des Epitheldefekts und eine Evaluierung des Heilungsverlaufs [36]. Das Gleiche gilt für präklinische korneale Wundheilungsstudien zur Beurteilung der Wirkung von epithelisierungsfördernden Substanzen [37]. Des Weiteren können durch die hoch aufgelöste Bildgebung in der Hornhaut Fälle von rezidivierenden Hornhauterosionen, z.…”

Section: Ultrahoch Aufgelöste Optische Kohärenztomografieunclassified

Bildgebung in der Kornea mittels optischer Kohärenztomografie – historische Entwicklung und neueste technische Fortschritte

Werkmeister

Stegmann

Santos

et al. 2018

Klin Monatsbl Augenheilkd

Self Cite

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ZusammenfassungDie optische Kohärenztomografie (OCT) hat seit ihrer Einführung für die retinale Bildgebung in den 90er-Jahren eine rasante Entwicklung genommen und die Ophthalmologie revolutioniert. Während sie zu Beginn nur zur Untersuchung der Retina zum Einsatz kam, wurden in der Zwischenzeit auch zahlreiche Systeme zur Beurteilung des vorderen Augenabschnitts entwickelt. Basierend auf der Detektion und Verarbeitung des vom Gewebe zurückreflektierten und gestreuten Lichts, eröffnete sie dem Ophthalmologen völlig neue Möglichkeiten zur Untersuchung der Strukturen des vorderen Augenabschnitts. Je nach technischer Umsetzung erlauben OCT-Systeme für den vorderen Augenabschnitt die präzise Vermessung einzelner Schichten der Kornea und des Kammerwinkels oder – in Form von ultrahoch auflösender OCT – die detailreiche Darstellung der Hornhautmorphologie mit nahezu histologischer Auflösung. Letztere könnte durch weitere technische Entwicklungen vor allem hinsichtlich der Erhöhung der Aufnahmegeschwindigkeit zu einem wesentlichen Werkzeug in der Differenzialdiagnose und Verlaufsbeobachtung verschiedenster Erkrankungen der Hornhaut werden, das auch neue Einsichten in die Pathophysiologie dieser Erkrankungen liefert.

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Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model

Cited by 37 publications

References 31 publications

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Bildgebung in der Kornea mittels optischer Kohärenztomografie – historische Entwicklung und neueste technische Fortschritte

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