Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner‐masked, randomized, controlled clinical trial

Abstract

Topical application of hyaluronic-acid exhibits positive impact on post-operative pain, burning sensation and accelerates palatal wound healing in terms of epithelization and color match.

Clinical efficacy of a chlorhexidine‐based mouthrinse containing hyaluronic acid and an antidiscoloration system in patients undergoing flap surgery: A triple‐blind, parallel‐arm, randomized controlled trial

“…The authors failed to find significant intergroup differences in plaque levels, bleeding index, presence of inflammation around the suture and presence of granulation tissue . In contrast, beneficial clinical effects were previously reported for HA when topically applied in a gel form in oral surgery as well as periodontal therapy . Some hypotheses can be advanced to explain the lack of effect of HA as observed in this study.…”

Patient morbidity at the palatal donor site depending on gingival graft dimension

“…Both PRF and hyaluronic-acid may provide significant benefits for wound healing parameters and reduce pain. 24,25 In our study, all patients were administered palatal stents. Thus complaints about the donor site (discomfort, pain, bleeding) might have decreased due to a reduction in pressure over the wound, independent of the graft length and thickness.…”

Platelet Rich Fibrin Versus Hyaluronic Acid as palatal wound Dressings following epithelialized free gingival graft harvest: A randomized controlled clinical trial

“…At day 30 and 90 there was no statistically significant difference between both groups. Yildrim et al 2018 (19) conducted that 0.2% HA showed less pain than the control group on day 7.…”

“…(18) HA has an important part in wound healing, it possesses a role in the migration and adherence of polymorph nuclear leucocytes and macrophages at the inflamed site and phagocytosis of invading (1589) microbes, promotes cell proliferation, migration of cells into granulation tissue matrix and granulation tissue organization. (18) Yildrim et al 2018 (19) performed a study that evaluated the effect of two different concentrations (0.2 & 0.8%) of topical HA on post-operative patient discomfort and wound healing of palatal donor sites following FGG. The study concluded a significant complete epithelization and post-operative pain reduction in patients treated with 0.2% HA gel.…”

“…The study concluded a significant complete epithelization and post-operative pain reduction in patients treated with 0.2% HA gel. (19) Considering the high demand to target the patient centered outcomes, this study attempted to minimize patient's pain and discomfort after FGG procedure, platelets rich fibrin versus hyaluronic acid as a palatal wound dressing were investigated on the incidence and severity of postoperative pain, post-surgical bleeding and palatal wound healing following epithelialized free gingival graft harvesting in a randomized controlled clinical trial.…”