Effect of transcranial static magnetic stimulation on intracortical excitability in the contralateral primary motor cortex

Shibata, Sumiya; Watanabe, Tatsunori; Yukawa, Yoshihiro; Minakuchi, Masatoshi; Shimomura, Ryota; Mima, Tatsuya

doi:10.1016/j.neulet.2020.134871

Cited by 16 publications

(16 citation statements)

References 35 publications

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“…Namely, the MEPs decreased in the right hand and increased in the left hand after tSMS, suggesting that the suppression of the cortical excitability in the unilateral hemisphere can induce the facilitation of the excitability in the contralateral hemisphere. Since a previous study reported that the MEP amplitude was not facilitated after tSMS of 20-min duration over the contralateral M1 25 , this transient facilitation effect in the contralateral hemisphere after 30-min intervention is a novel finding of this study. However, compared to the suppression effect directly induced by tSMS, the facilitation effect of contralateral M1 was only shown just after tSMS.…”

Section: Discussionsupporting

confidence: 50%

Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Takamatsu

Koganemaru

Watanabe

et al. 2021

Sci Rep

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Transcranial static magnetic stimulation (tSMS) has been focused as a new non-invasive brain stimulation, which can suppress the human cortical excitability just below the magnet. However, the non-regional effects of tSMS via brain network have been rarely studied so far. We investigated whether tSMS over the left primary motor cortex (M1) can facilitate the right M1 in healthy subjects, based on the hypothesis that the functional suppression of M1 can cause the paradoxical functional facilitation of the contralateral M1 via the reduction of interhemispheric inhibition (IHI) between the bilateral M1. This study was double-blind crossover trial. We measured the corticospinal excitability in both M1 and IHI from the left to right M1 by recording motor evoked potentials from first dorsal interosseous muscles using single-pulse and paired-pulse transcranial magnetic stimulation before and after the tSMS intervention for 30 min. We found that the corticospinal excitability of the left M1 decreased, while that of the right M1 increased after tSMS. Moreover, the evaluation of IHI revealed the reduced inhibition from the left to the right M1. Our findings provide new insights on the mechanistic understanding of neuromodulatory effects of tSMS in human.

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Section: Discussionsupporting

confidence: 50%

Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Takamatsu

Koganemaru

Watanabe

et al. 2021

Sci Rep

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“…Meanwhile, as shown in this and previous tSMS studies, a short after-effect may be a disadvantage compared with a traditional NIBS tools. Since tSMS over the motor cortex for 30 min has been demonstrated to result in an after-effect of 30 min [10], it should be investigated whether a longer duration of tSMS over the temporal cortex similarly induces long-lasting after-effects on visuo-spatial cognitive function. Given the short after-effect, another potential clinical use could be to repeat tSMS in combination with rehabilitation for 4-8 weeks, like interventions using rTMS and tDCS [71,72].…”

Section: Clinical Applicationmentioning

confidence: 99%

“…Given that the magnet used for tSMS is safer, cheaper, and easier to use as compared to the other conventional NIBS techniques, tSMS has the attractive potential to be used in clinical practice to alleviate symptoms of various central nervous system diseases. For instance, in stroke patients tSMS may be effective in restoring the sensorimotor function of paralyzed limbs by suppressing excessive inter-hemispheric inhibition from the intact hemisphere to the affected hemisphere via the corpus callosum [1,[7][8][9][10][11][12][13][14]. Also, tSMS's ability to reduce the amplitude of intra-epidermal electrical stimulation-evoked potentials [15] may lead to the development of chronic pain management.…”

Section: Introductionmentioning

confidence: 99%

Influence of Static Magnetic Field Stimulation on the Accuracy of Tachystoscopically Presented Line Bisection

et al. 2020

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Transcranial static magnetic stimulation (tSMS) has been known to reduce human cortical excitability. Here, we investigated whether tSMS would modulate visuo-spatial cognition in healthy humans. Subjects performed a visuo-spatial task requiring judgements about the symmetry of pre-bisected lines. Visual stimuli consisted of symmetrically or asymmetrically transected lines, tachystoscopically presented for 150 ms on a computer monitor. Task performance was examined before, immediately after, and 10 min after tSMS/sham stimulation of 20 min over the posterior parietal cortex (PPC: P4 from the international 10–20 system) or superior temporal gyrus (STG: C6). Nine out of 16 subjects misjudged pre-bisected lines by consistently underestimating the length of the right-side segment (judging lines to be exactly pre-bisected when the transector was located to the left of the midpoint, or judging the left-side segment to be longer when the transector was located at the midpoint). In these subjects showing a leftward bias, tSMS over the right STG reduced the magnitude of the leftward bias. This did not occur with tSMS over the right PPC or sham stimulation. In the remaining right-biased subjects, no intervention effect was observed with any stimulation. Our findings indicate that application of tSMS over the right STG modulates visuo-spatial cognition in healthy adults.

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“…An increase in alpha-band oscillatory power has also been demonstrated with tSMS over the temporal or occipital areas [15,16]. Furthermore, tSMS can modulate the activity of brain regions interconnected with the site of stimulation [17][18][19][20]. In particular, tSMS over the M1 can increase contralateral M1 excitability [19].…”

Section: Introductionmentioning

confidence: 95%

Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex

et al. 2021

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Transcranial static magnetic field stimulation (tSMS) can modulate human cortical excitability and behavior. To better understand the neuromodulatory effect of tSMS, this study investigates whether tSMS applied over the left dorsolateral prefrontal cortex (DLPFC) modulates working memory (WM) performance and its associated event-related potentials (ERPs). Thirteen healthy participants received tSMS or sham stimulation over the left DLPFC for 26 min on different days. The participants performed a 2-back version of the n-back task before, during (20 min after the start of stimulation), immediately after, and 15 min after the stimulation. We examine reaction time for correct responses, d-prime reflecting WM performance, and the N2 and P3 components of ERPs. Our results show that there was no effect of tSMS on reaction time. The d-prime was reduced, and the N2 latency was prolonged immediately after tSMS. These findings indicate that tSMS over the left DLPFC affects WM performance and its associated electrophysiological signals, which can be considered an important step toward a greater understanding of tSMS and its use in studies of higher-order cognitive processes.

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Effect of transcranial static magnetic stimulation on intracortical excitability in the contralateral primary motor cortex

Cited by 16 publications

References 35 publications

Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Influence of Static Magnetic Field Stimulation on the Accuracy of Tachystoscopically Presented Line Bisection

Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex

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