Recognizing the significance of administrative empowerment and job satisfaction is vital in improving the organization's human resource efficiency. So, the purpose of this study is to see how administrative empowerment affects employee satisfaction at the Directorate of Health in the Northern Border Region. The study used descriptive and analytical methodology. The questionnaire was distributed to 167 employees found in the Directorate of Health in the Northern Border Region. The study found several results, the most important of which is the existence of the impact of administrative empowerment with its five dimensions (participation in decision-making-effective communication-employee motivation-training, and continual education-teamwork) explained by 67% of the variance in the level of job satisfaction of the employees. The main recommendation of the study was to strengthen teamwork, consolidate cooperation, linking the material and moral incentives with a set of objective standards to increase employees’ motivation towards teamwork and thus increase job satisfaction besides, increasing opportunities for participation in policymaking. Moreover, efforts should be exerted to establish robust internal communication channels that serve various administrative fields and enable workers to increase their capabilities and job skills.