Abstract:The effect of subchronic treatment with l‐dopa/carbidopa or l‐selegiline on striatal dopamine transporters (DAT) was examined in patients with idiopathic Parkinson's disease with SPECT (single photon emission computed tomography) using [123I]β‐CIT (2β‐carbomethoxy‐3β‐[4‐iodophenyl]tropane) as the radiotracer. Patients who were not currently being treated with these medications were given either 750 mg l‐dopa/carbidopa per day (n = 8) or 10 mg l‐selegiline per day (n = 8). [123I]β‐CIT imaging was performed thre… Show more
“…For animal studies, the results might be affected by the methodologies such as dose of L-DOPA, administration route, administration period and DAT expression status. Whereas, in nonhuman primates and human studies, L-DOPA does not affect the DAT binding (17)(18)(19). In conclusion, L-DOPA effect on DAT binding are unpredictable.…”
Section: Therapeutic Drug Effects On [ 18 F]fe-pe2i Bindingmentioning
on lesioned and unlesioned striatal BPND was also assessed in the PD rats.
Results:The BPND was significantly lower in the lesioned striatum than in the iii
“…For animal studies, the results might be affected by the methodologies such as dose of L-DOPA, administration route, administration period and DAT expression status. Whereas, in nonhuman primates and human studies, L-DOPA does not affect the DAT binding (17)(18)(19). In conclusion, L-DOPA effect on DAT binding are unpredictable.…”
Section: Therapeutic Drug Effects On [ 18 F]fe-pe2i Bindingmentioning
on lesioned and unlesioned striatal BPND was also assessed in the PD rats.
Results:The BPND was significantly lower in the lesioned striatum than in the iii
“…Dopaminergic treatment can change the amount of available dopamine at the synaptic level, which may differentially influence the regulation of AADC and DAT. Although a number of studies have not revealed an effect of dopaminergic treatment on presynaptic dopaminergic imaging measures, 8,24,25 other evidence suggests that dopaminergic treatment can affect these parameters in PD patients. 26,27 Specifically, Guttman et al 27 reported a decline in DAT binding after treatment with levodopa, which was not significant after pramipexole treatment.…”
Section: Dopaminergic Imaging In Parkinsons Disease: Neuroprotection mentioning
Summary:In this review, we discuss the role of neuroimaging in assessing treatment options for movement disorders, particularly Parkinson's disease (PD). Imaging methods to assess dopaminergic function have recently been applied in trials of potential neuroprotective agents. Other imaging methods using regional metabolism and/or cerebral perfusion have been recently introduced to quantify the modulation of network activity as an objective marker of the treatment response. Both imaging strategies have provided novel insights into the mechanisms underlying a variety of pharmacological and stereotaxic surgical treatment strategies for PD and other movement disorders.
“…In addition, DAT imaging may be of value for assessing neuroprotective therapies (Pirker et al, 2002). Various authors have shown that treatment with Ldopa or dopaminergic agonists in PD does not cause significant occupation or modulation in the number of striatal DAT labed with β-CIT (Innis et al, 1999;Ahlskog et al, 1999). However, it should be noted that all studies are limited by the small sample size and short treatment duration.…”
123-I Ioflupane (Datscan®) presynaptic imaging has been shown to have a significant utility in the assessment of patients with movement disorders 123-I Ioflupane SPECT is able to distinguish between Parkinson's disease (PD) and other forms of parkinsonism without degeneration of the nigrostriatal pathway, including a common movement disorder such as essential tremor, and to assess disease progression in PD and other neurodegenerative disordersinvolving the substantia nigra.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.