1988
DOI: 10.1016/0378-8741(88)90229-2
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Effect of Trigonella foenum graceum on blood glucose levels in normal and alloxan-diabetic mice

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Cited by 82 publications
(40 citation statements)
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“…Our findings are in agreement with the earlier reports in the scientific literature; showing significant fall in blood glucose levels both in the normal as well as diabetic animals when treated with fenugreek seeds extract (Ghafghazi et al, 1977;Khosla et al, 1995;AbdelBarry et al, 1997;Ajabnoor and Tilmisany, 1998;Al-Habori and Raman, 1998). The hypoglycemic effect observed during the current toxicity studies on fenugreek seeds and the results of the earlier investigations add support to the traditional claim and medicinal use of fenugreek seeds by diabetic patient in different countries (Haddad et al, 2001;Beutler and Der Marderosian, 2002;Otoom et al, 2006).…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Our findings are in agreement with the earlier reports in the scientific literature; showing significant fall in blood glucose levels both in the normal as well as diabetic animals when treated with fenugreek seeds extract (Ghafghazi et al, 1977;Khosla et al, 1995;AbdelBarry et al, 1997;Ajabnoor and Tilmisany, 1998;Al-Habori and Raman, 1998). The hypoglycemic effect observed during the current toxicity studies on fenugreek seeds and the results of the earlier investigations add support to the traditional claim and medicinal use of fenugreek seeds by diabetic patient in different countries (Haddad et al, 2001;Beutler and Der Marderosian, 2002;Otoom et al, 2006).…”
Section: Discussionsupporting
confidence: 83%
“…Another report suggested that the hypoglycemic effect of fenugreek chemical constituents might be mediated through stimulation of insulin synthesis and/or secretion from the cells of Langerhans (Puri et al, 2002). The hypoglycemic effect of fenugreek treatment was slow and sustained, and without any risk of developing severe hypoglycemia (Ali et al, 1995;Ajabnoor and Tilmisany, 1998). Data from the literature further suggested that fenugreek treatment has been used to ameliorate 1-thyroxine-induced hyperglycemia in rats (Tahiliani and Kar, 2003).…”
Section: Discussionmentioning
confidence: 98%
“…It is a multifactorial disorder with increasing incidence throughout the world [25]. The Alloxan a diabetogenic used in the present study, a cyclic urea derivative, which selectively destroys insulin-producing pancreatic cells by free radical-mediated damage and when administered to rodents cause an insulindependent diabetes mellitus [26] and has been widely used for the induction of experimental diabetes in animals.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, the acute effect of the extract was studied by Oral Glucose Tolerance Test (OGTT). For the chronic study, we have made the animals diabetic by administering Alloxan and treated the animals with varying doses of extract for 21 d. The blood glucose level in animals was estimated at 1 st , 7 th , 14 th and 21 st The oral glucose tolerance test is performed to study the acute effects of extract in diabetic animals and it based on the ability of the body to utilize or tolerate the glucose load administered orally [24,25]. In OGTT, induction of diabetes in toxic control rats resulted in increased concentration of blood glucose due to the inability of the system to utilize glucose in the absence of insulin.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies mentioned that Fenugreek helps lowering of blood glucose level 5 , cholesterol levels 6 and an effective treatment for both type1 and type 2 diabetes. It is also being studied for its cardiovascular benefits.…”
mentioning
confidence: 99%