Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects

Degenring, Robert F.; Vey, Sonja; Kamppeter, Bernd A.; Budde, Wido M.; Jonas, Jost B.; Sauder, Gangolf

doi:10.1007/s00417-006-0377-4

Cited by 66 publications

(52 citation statements)

References 32 publications

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“…Biro and colleagues (2008) found no differences between the preoperative and postoperative day 1 foveal and perifoveal retinal thickness. However, increases were found in the perifoveal 3.0 and 6.0 mm diameter and foveal area thickness on postoperative days 7, 30, and 60 (Degenring et al 2007). No signifi cant differences in foveal thicknesses were detected in other studies in week 1 (Cheng et al 2002;Degenring et al 2007).…”

Section: Discussionmentioning

confidence: 53%

“…However, increases were found in the perifoveal 3.0 and 6.0 mm diameter and foveal area thickness on postoperative days 7, 30, and 60 (Degenring et al 2007). No signifi cant differences in foveal thicknesses were detected in other studies in week 1 (Cheng et al 2002;Degenring et al 2007). Cheng and colleagues (2002) observed no increases in mean foveal thickness in week 1 in 80 patients.…”

Section: Discussionmentioning

confidence: 61%

“…Based on previous research (Degenring et al 2007;Biro et al 2008), it was hypothesized that the foveal thickness would be increased postoperatively. In line, pre-and postoperative foveal thicknesses associations were examined for the fi rst time.…”

Section: Introductionmentioning

confidence: 99%

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Foveal thickness after phacoemulsification as measured by optical coherence tomography

Georgopoulos

Papaconstantinou²,

Niskopoulou³

et al. 2008

OPTH

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Background: Despite a signifi cant body of research, no consistency on postoperative foveal thickness as measured by optical coherence tomography (OCT), can be recorded. The purpose of our study was to evaluate the effect of uncomplicated cataract surgery in the thickness of the retina in the foveal area during the early postoperative period. Methods: In a prospective study, 79 eyes were assessed by OCT, on day 1, and weeks 2 and 4 after uncomplicated phacoemulsifi cation with intraocular lens implantation in the Athens University Clinic. The outcome measure was the thickness of the retina in the foveal area. Results: The thickness of the retina preoperatively is signifi cantly smaller (150.4 ± 18.8) (p Ͻ 0.05) than the thickness of the retina on day 1 (171.8 ± 21) and week 2 (159.7 ± 19) and returned to the initial levels on week 4 (152 ± 17.1). The estimated correlation coeffi cients between preoperative and postoperative thickness of the retina were signifi cant (p Ͻ 0.05). Conversely, no association was found between postoperative visual acuity and thickness of the retina, neither between the phacoemulsifi cation energy and retinal thickness. Operation time, although inversely related with postoperative visual acuity, was not associated with the thickness of the retina. Conclusions: Following phacoemulsifi cation, an increase in the foveal thickness was detected in the early postoperative period, quantifi ed and followed up by OCT. The foveal thickness returned to the preoperative level, 1 month following surgery in our study. No association was shown between intraoperative parameters and increased postoperative retinal thickness.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 61%

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Foveal thickness after phacoemulsification as measured by optical coherence tomography

Georgopoulos

Papaconstantinou²,

Niskopoulou³

et al. 2008

OPTH

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“…Degenring ve ark. [8] DM olan ve olmayan hastalarda komplike olmayan standart katarakt ameliyatından sonraki birinci ve dör-düncü haftada maküla değişikliklerini OKT ile incelediklerinde; ameliyat sonrası maküla kalınlığı ve maküla hacminde subklinik bir artış olduğunu ve bu artışın diyabetli hasta grubunda istatistiksel olarak anlamlı olduğunu ve buna paralel olarak da dördüncü haftada görme keskinliğinin bu grupta diyabeti olmayan gruba göre daha düşük olduğunu gözlemlemişlerdir.…”

Section: Discussionunclassified

Results of Phacoemulsification Surgery in Diabetic and Non-Diabetic Patient groups

Yavuz¹,

Kuğu²,

Yılmaz³

et al. 2013

J Kartal TR

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“…[65][66][67] the pathogenesis of these complications may be related to the changes and rise in the concentration of VEGF in response to surgical trauma and inflammation. 29 one study investigated cmE following cataract surgery in patients with diabetic retinopathy and they reported that 6 % of the controls and 12 % of diabetic eyes developed a clinical cmE up to 6…”

Section: Prophylactic Intravitreal Bevacizumab For Diabetic Macular Omentioning

confidence: 99%

Intravitreal Bevacizumab for Treatment of Diabetic Macular Oedema

Ramin¹,

Azarmina²,

Soheilian³

2013

European Ophthalmic Review

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Abstractdiabetic macular oedema (dMo) is a leading cause of vision loss in the working-age population worldwide. Numerous early studies suggest an important role for intravitreal anti-VEGF agents such as bevacizumab in the management of dMo. We reviewed manuscripts that had investigated pharmacokinetic, efficacy, safety, dose and frequency of intravitreal bevacizumab (iVB) injections as well as effect of macular ischaemia, initial macular thickness and optical coherence tomography (ocT) patterns of dMo on the final results of treatment with iVB. in summery literature searches disclosed that almost all studies published up to now provided evidence supporting use of iVB for treatment of either naïve or persistent dMo in short and long term up to 2 years. KeywordsBevacizumab, clinically significant diabetic macular oedema, diabetic retinopathy, macular laser photocoagulation, triamcinolone acetonide Pathophysiology of Diabetic Macular OedemaSeveral physiological mechanisms have been proposed to contribute to the pathogenesis of dMo. The exact mechanisms by which elevated glucose initiates the vascular disruption and results in the ultimate blood retinal barrier (BRB) breakdown in diabetic retinopathy remain poorly defined. There are several hypotheses that contribute to dMo formation including:1. increase in hydrostatic pressure that was described by Starling.Similar to congestive heart failure, dMo can be considered as a congestive macular oedema. Based on Starling law hydrostatic and oncotic pressure counteract each other; pressure differences are responsible for the movement of fluid between tissue beds and intravascular spaces. changes in vessel diameter together with increased hydrostatic pressure can contribute to oedema formation. Furthermore the above mentioned mechanism can increase in shear stress which may cause damage to endothelial cells and cause endothelial decoupling over time. [9][10][11] 2. ischaemia secondary to hypoxia can lead to decrease in oxygen tension in retina which results in vasodilation of the retinal vessels that can increase macular oedema by increasing hydrostatic pressure. increased in oxygen tension may decrease macular oedema by reversing the earlier described mechanism.3. hyperglycaemia per se or together with other mechanisms may induce endothelial dysfunction and cause more vascular damage. [12][13][14] 4. increased VEGF production: VEGF mediates angiogenesis by promoting endothelial cell migration, proliferation and survival.amongst the various VEGF family members, VEGF-a, is a critical regulator of ocular angiogenesis and vascular permeability. 15VEGF can cause rapid post-translational modifications to tight junctions by stimulating occluding phosphorylation and inducing tyrosine phosphorylation of zonula occludence that result in

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Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects

Abstract: Foveal thickness and foveal volume demonstrate a subclinical increase within 4 weeks after uncomplicated cataract surgery in up to 1/3 of the patients. The amount and frequency of early postoperative subclinical retinal thickening was higher than expected.

Cited by 66 publications

References 32 publications

Foveal thickness after phacoemulsification as measured by optical coherence tomography

Foveal thickness after phacoemulsification as measured by optical coherence tomography

Results of Phacoemulsification Surgery in Diabetic and Non-Diabetic Patient groups

Intravitreal Bevacizumab for Treatment of Diabetic Macular Oedema

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