Effect of various drugs on carrageenin-induced oedema in the rat hind paw

Niemegeers, C. J. E.; Verbruggen, Frank; Janßen, Paul

doi:10.1111/j.2042-7158.1964.tb07414.x

Cited by 70 publications

(22 citation statements)

References 9 publications

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“…The development of the inflammatory response induced by carrageenan (paw edema and pleurisy) is characterized by an initial stage (1-2 h) which is dependent on the release of histamine, serotonin and bradykinin, followed by a later stage (3-4 h) which is maintained principally by the release of prostanoids (Crunkhorn & Meacock, 1971;Niemegeers et al, 1964). It has also been shown that nitric oxide (NO) has an important role as much as in the regulation of vascular permeability as in cell migration induced by proinflammatory agents, including carrageenan (Vinegar et al, 1982;Costa et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Daniel¹,

Sartoretto²,

Schmidt³

et al. 2009

Rev. bras. farmacogn.

168

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RESUMO: "Atividades antiinflamatória e antinociceptiva do eugenol em modelos experimentais em animais". Eugenia caryophyllata, popularmente conhecida como "cravo-daíndia", cresce naturalmente na Indonésia e é cultivada em várias partes do mundo, incluindo o Brasil. O cravo-da-índia é utilizado em culinária, em farmácia, perfumaria e cosméticos. O óleo essencial extraído do cravo-da-índia cujo principal componente é o eugenol tem sido utilizado em odontologia como anti-séptico e analgésico. O objetivo deste estudo foi avaliar as atividades antiinflamatória e antinociceptiva do eugenol de uso odontológico, administrado oralmente, em modelos experimentais in vivo. A atividade antiinflamatória do eugenol foi avaliada através do volume de exsudato e migração leucocitária no teste de pleurisia e do edema de pata de rato induzido pela carragenina. A atividade antinociceptiva foi avaliada através dos testes de contorções induzidas pelo ácido acético e da placa quente. O eugenol (200 e 400 mg/kg) reduziu o volume de exsudato pleural sem interferir na contagem de leucócitos totais presentes na pleura. Na dose de 200 mg/kg, o eugenol inibiu significativamente o edema de pata, 2-4 h após a injeção do agente flogístico. No teste da placa quente, a administração do eugenol (100 mg/kg) mostrou atividade significativa à reação de desconforto-tempo dependente, avaliada como a latência da resposta, inibida pela meperidina. Eugenol na doses de 50, 75 e 100 mg/kg apresentou efeito antinociceptivo significativo no teste de contorções abdominais induzidas pelo ácido acético em comparação com o grupo controle. Os dados obtidos indicam que o eugenol apresenta atividade antiinflamatória e antinociceptiva periférica.Unitermos: Eugenia caryophyllata, Syzygium aromaticum, Myrtaceae, atividade antiinflamatória, atividade antinociceptiva, óleo essencial, cravo-da-índia.ABSTRACT: Eugenia caryophyllata, popular name "clove", is grown naturally in Indonesia and cultivated in many parts of the world, including Brazil. Clove is used in cooking, food processing, pharmacy; perfumery, cosmetics and the clove oil (eugenol) have been used in folk medicine for manifold conditions include use in dental care, as an antiseptic and analgesic. The objective of this study was evaluated the anti-inflammatory and antinociceptive activity of eugenol used for dentistry purposes following oral administration in animal models in vivo. The anti-inflammatory activity of eugenol was evaluated by inflammatory exudates volume and leukocytes migration in carrageenan-induced pleurisy and carrageenan-induced paw edema tests in rats. The antinociceptive activity was evaluated using the acetic acid-induced writhing and hot-plate tests in mice. Eugenol (200 and 400 mg/kg) reduced the volume of pleural exudates without changing the total blood leukocyte counts. At dose of 200 mg/kg, eugenol significantly inhibited carrageenan-induced edema, 2-4 h after injection of the flogistic agent. In the hot-plate test, eugenol administration (100 mg/kg) showed unremarkable activity agai...

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Daniel¹,

Sartoretto²,

Schmidt³

et al. 2009

Rev. bras. farmacogn.

168

View full text Add to dashboard Cite

show abstract

“…and Table 1.). The inhibitory effect of chlorpromazine on the delayed phase may depend on its membrane stabilizing activity (24,25) rather than its tranquilizing activity, because haloperidol, which possesses about 30 times more potent tranquilizing activity and 3 times more potent anti-edema activity (26,27) and one third to one thirty times less anti histaminic activity than chlorpromazine (28), did not inhibit the delayed phase as is shown in Table 1. Sigg et al (29) and Yamasaki et al (30) reported that antihistaminics, chlor promazine and non-steroidal anti-inflammatory agents inhibited mast-cell degranulation, while steroidal anti-inflammatory agents did not.…”

Section: Combined Effect Of Antihistaminic and Anti-inflannnator;i° Amentioning

confidence: 95%

EARLY and DELAYED PHASES OF HIND PAW EDEMA IN RATS

Nakamura

Shimizu

1974

Japanese Journal of Pharmacology

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Abstract-Interactionbetween early and delayed phases in developmental process of hind paw swelling was investigated in rats using the mixed phlogistics-induced paw edema technique. Swelling induced by a mixture of carrageenin and Kaolin was observed in both the early and delayed phases. Despite of the augmentation of the early phase induced by the mixture, the delayed phase was not altered. The delayed phase was not reduced by treatment with antihistaminics and/or anti-serotonin a gents, whereas the early phase was inhibited with those agents. The delayed phase was inhibited with anti-inflammatory agents without alterating the early phase. The potentiating effect on the delayed phase was observed in the combined use of flufe namic acid and diphenhydramine.From these results, it is concluded that the de layed phase is independent from the early phase in the developmental process of hind paw edema, but it is related to the early phase in chemotherapy.Furthermore, effects of various agents on the mixed phlogistics-induced hind paw edema, the some of which included 0.1 % histamine, 0.01 % serotonin, 0.5 % carrageenin and 5 % Kaolin were investigated by localized and oral application and are discussed herein.

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“…The results of the present study showed that methanol extract of P. major significantly inhibited the formation of the rat paw edema in the early and late phases. Most of the anti-inflammatory medicines are effective in the last phase of edema formation [37]. As shown in Table 2, standard drug diclofenac sodium showed significant inhibition of edema at 4 th hr (81.48%).…”

Section: In Vivo Anti-inflammatory Activitymentioning

confidence: 87%

Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

Vandana¹,

Gupta²,

Mukerjee³

2017

Asian J Pharm Clin Res

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Objective: This study aims to perform phytochemical screening and investigate anti-inflammatory activity of extract from aerial part of the plant Plantago major L.Methods: Preliminary phytochemical screening of plant extract was carried out using standard qualitative procedures and anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in male Wistar albino rats using plethysmometer. Diclofenac sodium (10 mg/kg, b.w.) was used as standard drug.Results: Preliminary phytochemical screening of the different extracts revealed that they were rich in secondary metabolite compounds such as carbohydrates, tannins, steroids, flavonoids, terpenoids, glycosides, fats and oils, alkaloids, phenolic compounds, and iridoid glycosides. The antiinflammatory activity was evaluated using carrageenan-induced paw edema models in Wistar albino rats. The anti-inflammatory activity of methanolic extract (ME) was found to be dose dependent in carrageenan-induced paw edema model. The ME has shown significant (p<0.05) inhibition of paw edema, 61.11% and 55.55% on 4 th hr at the doses of 900 and 600 mg/kg, respectively. Conclusion:The results of the present study demonstrate that ME of the aerial parts of the plant possess significant (p<0.05) anti-inflammatory potential.

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Effect of various drugs on carrageenin-induced oedema in the rat hind paw

Cited by 70 publications

References 9 publications

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

EARLY and DELAYED PHASES OF HIND PAW EDEMA IN RATS

Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

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