Effect of Verapamil on Phosphate-Induced Nephrocalcinosis. † 2128

Alon, Uri; Nichols, M. A.; Guss, Daniel; Alon, Michal M

doi:10.1203/00006450-199604001-02152

Cited by 5 publications

(11 citation statements)

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“…Furosemide used in premature neonates or in infants with congestive heart failure may induce nephrocalcinosis and formation of stones made of calcium oxalate, either pure or admixed with calcium phosphate, 111,112 with a strikingly increased calcium excretion. ESWL with adapted technology has been successfully used in small infants with persistent stones.…”

Section: Furosemidementioning

confidence: 99%

Drug-Induced Renal Stones

Daudon

Jungers²

2010

Urinary Tract Stone Disease

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Drug-induced stones represent about 1% of all renal stones. They involve two main mechanisms. The first one includes stones made of the drug and/or its metabolites identified by X-ray diffraction or infrared spectroscopy on the basis of their specific diagrams. Nowadays, the most commonly observed ones are antiproteases (such as indinavir) used in HIV-infected patients, high-dose sulfadiazine used for the treatment of cerebral toxoplasmosis, and abuse of ephedrine/guaifenesin-containing preparations, whereas triamterene, formerly the most often involved drug, is less frequently observed. The second one includes stones of common composition, induced by the metabolic effects of the drug on urinary pH and excretion of calcium, oxalate, phosphate, citrate, uric acid, or other purines. The most frequent causes are unsupervised calcium/vitamin D supplementation and carbonic anhydrase inhibitors, including anticonvulsants (such as topiramate). Incidence of metabolically induced stones is probably underestimated, because they are of apparently usual composition and may reveal long after drug withdrawal. Formation of iatrogenic calculi is favored by high-dose or long-lasting treatments, high renal excretion and low solubility of the drug or its metabolites, low urine output or inadequate urine pH, and is especially frequent in patients with a history of stones. Better awareness of potentially lithogenic drugs may allow more efficient prevention and reduce the incidence of drug-induced nephrolithiasis.

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Section: Furosemidementioning

confidence: 99%

Drug-Induced Renal Stones

Daudon

Jungers²

2010

Urinary Tract Stone Disease

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“…The proportion of female subjects was 54% (n=19). The mean follow -up was 4 years (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Demographic Characteristicsmentioning

confidence: 99%

“…Nephrocalcinosis (NC) is characterized by the deposition of calcium in the kidney parenchyma and tubules 1 . It is usually asymptomatic, especially during infancy and early childhood and diagnosed incidentally when ultrasound is performed for other reasons 1 . Reported clinical symptoms include renal colic in infants, gross or microscopic hematuria and/or sterile leukocyturia, mainly when associated to nephrolithiasis.…”

Section: Introductionmentioning

confidence: 99%

“…Reported clinical symptoms include renal colic in infants, gross or microscopic hematuria and/or sterile leukocyturia, mainly when associated to nephrolithiasis. Also, it is not unusual for NC to be diagnosed during systematic renal ultrasound examination of high--risk infants or as part of the diagnostic evaluation of urinary tract infection 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Recognized risk factors include genetic abnormalities in epithelial transport, metabolic disturbances, anatomical abnormalities, prematurity and urinary tract infections in the majority of pediatric patients 1 . The physiological mechanisms of preventing crystal formation and adhesion can be foiled by high amounts of a solute due to hyperabsorption (e.g., in vitamin A/D excess, chronic inflammatory bowel disease, small bowel syndrome), overproduction (e.g., primary hyperoxaluria), deranged epithelium (e.g., infection, prematurity), and tubular transport defects 2 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nephrocalcinosis in a portuguese pediatric population

Bota¹,

Andrade²,

Francisco³

et al. 2019

pjnh

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Néphrocalcinose de l’enfant

Monet-Didailler

Chateil

Allard

et al. 2021

Néphrologie & Thérapeutique

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Nous remercions la rédaction d'EMC-Pédiatrie pour son aimable autorisation de reproduction. RésuméLa néphrocalcinose est définie par des dépôts de phosphate de calcium ou d'oxalate de calcium dans le parenchyme rénal, en particulier dans les cellules épithéliales des tubules rénaux et dans le tissu interstitiel. Il faut la différencier des néphrolithiases où les dépôts calciques se situent dans les cavités excrétrices rénales. La néphrocalcinose chez l'enfant n'est pas si rare, avec une augmentation de son incidence chez les enfants nés prématurément. Souvent de découverte fortuite, ses étiologies sont multiples et peuvent être classées en fonction du type radiologique de néphrocalcinose : médullaire, corticale ou mixte (diffuse). Les causes principales retrouvées chez l'enfant concernent la néphrocalcinose médullaire et comportent les tubulopathies héréditaires, en particulier l'acidose tubulaire distale et la maladie de Dent, les anomalies métaboliques telles que l'hypercalciurie idiopathique et les hyperoxaluries, et les formes iatrogènes secondaires, notamment aux surdosages en vitamine D. Chez le nouveau-né, il s'agit principalement de l'hypercalciurie du prématuré dont l'origine, multifactorielle, est en grande partie iatrogène. L'hyperoxalurie primitive, qui entraîne une néphrocalcinose diffuse d'apparition précoce et conduit à une insuffisance rénale chronique, ne doit pas être méconnue et systématiquement être recherchée. Afin de pouvoir établir un diagnostic spécifique, il est essentiel de prendre en compte l'anamnèse familiale, le contexte clinique ainsi que les données biologiques complètes. Instituer précocement un traitement étiologique adapté permettrait de prévenir ou de retarder l'évolution vers une insuffisance rénale chronique.

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Effect of Verapamil on Phosphate-Induced Nephrocalcinosis. † 2128

Cited by 5 publications

References 0 publications

Drug-Induced Renal Stones

Drug-Induced Renal Stones

Nephrocalcinosis in a portuguese pediatric population

Néphrocalcinose de l’enfant

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