Effect of vitamin A supplemented diet on calcium oxalate renal stone formation in rats

Bardaoui, M; Sakly, R; Neffati, Fadoua; Najjar, Mohamed Fadhel; Hani, Abdelhamid El

doi:10.1016/j.etp.2009.08.005

Cited by 16 publications

(7 citation statements)

References 17 publications

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“…A deficiency are associated with a history of kidney stones and may indicate a role for these antioxidants in prevention. 10,11,33 The activities of hepatic glycolate oxidase and glycolate dehydrogenase were markedly enhanced in Vit. A and Vit.…”

Section: Discussionmentioning

confidence: 99%

“…In the kidney, these treatments are reported to diminish the increase in malondialdehyde (MDA) and the decrease in protective enzyme activity that are induced by chemical and pharmacological agents. 8 As experimental and clinical studies have demonstrated, the most frequently studied natural antioxidants with free radical scavengers to provide superior renal protection are vitamins A and carotenoids, E, C, B6, and antioxidant trace elements such as selenium and zinc (Zn) 8 –15 that can be easily and safety increased in tissues by supplementation. Medical treatment of stone-forming patients using pyridoxine is considered as an effective first-line therapy to decrease hyperoxaluria in patients who develop stones.…”

Section: Introductionmentioning

confidence: 99%

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The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats

et al. 2014

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Administration of natural antioxidants has been used to protect against nephrolithiasis. Urolithiasis was induced by ethylene glycol (EG) in Wistar rats. For 4 weeks, group 1 (control) was fed with a standard commercial diet. Group 2 received the same diet with 0.75% of EG. Group 3 received EG plus the diet and water added with antioxidant nutrients and lime juice as the dietary source of citrate (EG + AX). Group 4 same as group 3 with no EG in water. For 8 weeks, group 5 was fed the standard diet with EG in water for the first 28 days, followed by no EG. Group 6 received the diet with EG for the first 28 days, followed by discontinuation of EG and addition of antioxidant nutrients. Group 7 were provided the diet with antioxidant nutrients for 8 weeks. Group 8 received the diet with antioxidant nutrients for 4 weeks, followed by antioxidant nutrients with EG for the next 4 weeks. Blood samples were collected and kidneys were removed. The size and the mean number of crystal deposits in EG-treated groups was significantly higher than the EG-treated groups, added with antioxidant nutrients and lime juice. After 4 weeks, the mean concentration of malondialdehyde in group 2 was higher than the group 3, and significantly lower in group 4; and in groups 7 after 8 weeks, as well. After 8 weeks, supplementation developed less mean number of deposits in group 6 as compared to group 5; and in group 8, the crystal deposits was substantially less than either group 2 or group 5 (EG-treated rats). Elevated concentration of androgens (as promoters of the formation of renal calculi) as a result of EG consumption decreased following antioxidant supplementations. Results showed a beneficial effect of antioxidant and provided superior renal protection on treating and preventing stone deposition in the rat kidney.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats

et al. 2014

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“…Moreover, an increase in the urinary pH and higher excretion of citric acid was observed. The results indicate the beneficial effects of vitamin A supplementation against renal stone formation [91].…”

Section: Urolithiasis Experimental Studiesmentioning

confidence: 74%

Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions

et al. 2022

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Benign prostatic hyperplasia, urolithiasis, recurrent urinary tract infections, and chronic prostatitis are diseases that are commonly diagnosed worldwide. Carotenoids, including lycopene, are widely available in fruits and vegetables, and it is postulated that they can be used in the prevention and treatment of benign urological conditions. The aim of this review is to familiarize doctors and their patients with the current knowledge on carotenoids and their conversion products in selected urological diseases. Most of the experimental and clinical trials show a moderate effect of lycopene and vitamin A on studied parameters. Lycopene was shown to improve the IPSS score in BPH patients, and alleviate symptoms in those with chronic prostatitis. Intake of Vitamin A was associated with decrease of urinary tract reinfection rates. In studied rat models retinol also decreased urolithiasis formation. Although the results of the cited studies are generally promising, it is evident that more detailed and extensive research must be done in this field of medicine.

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“…In rats, vitamin A deficiency has been shown to reduce urinary citrate and pH, and to increase the presence of urinary calculi 51 , 52 (Table 1 ). Supplementation with high amounts of vitamin A (retinol) in a calcium oxalate stone rat model enhanced urinary citrate levels, increased urinary pH, and lowered the concentration of calcium and oxalate in renal tissues 53 . These changes observed in vitamin A-supplemented rats could be partially attributed to the ability of vitamin A to alter gene expression in cells in the collecting ducts, which have crucial roles in maintaining urinary pH 54 .…”

Section: Vitamin Amentioning

confidence: 99%

Vitamins as regulators of calcium-containing kidney stones — new perspectives on the role of the gut microbiome

Chmiel

Stuivenberg

et al. 2023

Nat Rev Urol

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Calcium-based kidney stone disease is a highly prevalent and morbid condition, with an often complicated and multifactorial aetiology. An abundance of research on the role of specific vitamins (B 6 , C and D) in stone formation exists, but no consensus has been reached on how these vitamins influence stone disease. As a consequence of emerging research on the role of the gut microbiota in urolithiasis, previous notions on the contribution of these vitamins to urolithiasis are being reconsidered in the field, and investigation into previously overlooked vitamins (A, E and K) was expanded. Understanding how the microbiota influences host vitamin regulation could help to determine the role of vitamins in stone disease.

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Effect of vitamin A supplemented diet on calcium oxalate renal stone formation in rats

Cited by 16 publications

References 17 publications

The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats

The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats

Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions

Vitamins as regulators of calcium-containing kidney stones — new perspectives on the role of the gut microbiome

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