Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells

Elattar, T. M. A.; Lin, Hsien S.

doi:10.1016/0952-3278(92)90194-n

Cited by 47 publications

(29 citation statements)

References 34 publications

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“…(Tang & Meydani, 2001). Both vitamin E and regular consumption of green tea have been reported to be associated with reduced risk of cancer (Attar, 1992;Das, 1994;Mukhtar et al 1994;Shklar & Schwartz, 1996;Nakachi et al 1998;Fleshner et al 1999). Green-tea catechins have been shown to be effective in reducing angiogenesis in in vivo animal models .…”

Section: Nutrition and Age-associated Chronic Diseasesmentioning

confidence: 99%

The Boyd Orr Lecture: Nutrition interventions in aging and age-associated disease

Meydani

2002

Proc. Nutr. Soc.

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Aging is a complex biological process, which usually is accompanied by changes in socioeconomic status, which may have a great impact on the physical and nutritional status of the elderly. Decreased food intake and a sedentary lifestyle in the growing numbers of the elderly increase their risk for malnutrition, decline of bodily functions and developing chronic diseases. Oxidative stress is believed to be an important factor in aging and many age-associated degenerative diseases. Modulation of oxidative stress by energy restriction in animals has been shown to be one of the mechanisms for retarding the aging process. Dietary antioxidants are regarded as being important in modulating oxidative stress of aging and age-associated diseases. Supplementation of the elderly with vitamin E has been shown to enhance immune response, delay onset of Alzheimer's disease, and increase resistance to oxidative injury associated with exercise. Vitamin E, in comparison with other antioxidants, is also effective in reducing viral titres, but not the longevity of middle-aged mice. Our studies have indicated that polyphenols or vitamin E may assist in preventing cardiovascular disease, in part by decreasing expression by endothelial cells of proinflammatory cytokines, adhesion molecules, and monocyte adhesion. Most recently, we have found that some of these antioxidants may prevent tumour growth by inhibiting angiogenesis via suppression of interleukin 8 and modulation of the cell junction molecule, VE-cadherin. These findings provide further support for the consumption of fruit and vegetables, which contain several forms of phytochemicals with antioxidant activity, in order to reduce the risk of cardiovascular disease and cancer, the leading causes of morbidity and mortality among the elderly.

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Section: Nutrition and Age-associated Chronic Diseasesmentioning

confidence: 99%

The Boyd Orr Lecture: Nutrition interventions in aging and age-associated disease

Meydani

2002

Proc. Nutr. Soc.

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“…9 The antioxidant vitamin E prevents the peroxidation of phospholipids, the release of arachidonic acid and hence its conversion to prostaglandin. 6 In this study we wanted to find out whether Vitamin E has some role in the reduction of pain during menstruation and in the reduction of duration of pain compared to placebo. In present study authors found that there is significant reduction in pain at the end of third month (p-0.002<0.05)…”

Section: Discussionmentioning

confidence: 99%

Vitamin E in the treatment of primary dysmenorrhoea

Vilvapriya

Vinodhini

2018

Int J Reprod Contracept Obstet Gynecol

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Background: The objective of this study is to determine the efficacy of Vitamin E in the treatment of primary dysmenorrhoea compared to the placebo.Methods: Sixty women, aged 17-25 years old who suffered from primary dysmenorrhoea, among 1000 Women attending the gynec OPD in Kilpauk Medical College. 30 women were given 200 units of vitamin E (each tablet twice daily) and 30 were given a placebo tablets (each tablet twice daily). The treatment began two days before the beginning of menstruation and continued through the first three days of bleeding. The severity of pain and duration of pain before and after the treatment was studied. Treatment in both groups was carried out in three consecutive menstrual periods.Results: As to the findings, the mean age of the participants was 22.6 years. There was a significant difference between the pre- and post-treatment periods in terms of pain severity (P=0.72 and P=0.002, respectively) and pain duration (P=0.514 and P=0.027, respectively) in Vitamin E group. There was a significant difference observed between the Vitamin E group and placebo group regarding the mean of pain severity and duration (P=0.002 and p=0.027 respectively).Conclusions: Vitamin E helps to relieve pain in primary dysmenorrhoea. As this is a relatively easier method for control of pain with lesser amount of side effects and as it is cost effective, it can be considered as a universal drug in the treatment of primary dysmenorrhoea.

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“…Both agents at high doses inhibited prostaglandin synthesis, but vitamin E stimulated synthesis at low concentrations. 86 It is difficult to draw specific conclusions from these limited disparate studies. It is reasonable to conclude that cell growth may be altered by the presence of certain prostaglandin subclasses.…”

Section: Prostaglandin Metabolism In Cell Linesmentioning

confidence: 98%

Arachidonic acid metabolism: A primer for head and neck surgeons

Ondrey

1998

Head & Neck

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Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells

Cited by 47 publications

References 34 publications

The Boyd Orr Lecture: Nutrition interventions in aging and age-associated disease

The Boyd Orr Lecture: Nutrition interventions in aging and age-associated disease

Vitamin E in the treatment of primary dysmenorrhoea

Arachidonic acid metabolism: A primer for head and neck surgeons

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