Effect of Vitamin C Deficiency on the Metabolism of Drugs and Nadph-Linked Electron Transport System in Liver Microsomes

Kato, Ryuichi; Takanaka, Akira; Oshima, Takao

doi:10.1254/jjp.19.25

Cited by 52 publications

(10 citation statements)

References 21 publications

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“…Further investigation is required to determine whether the nitro and azo reductases of the worms studied are similar to the mammalian reductases which are both microsomal, requiring cytochrome P-450 (Sasame & Gillette, 1969), and non-microsomal, requiring NADPH (Kato et al, 1969) ; or whether they are similar to the bacterial systems, that require NADH, Mn++, and cysteine (Saz & Slie, 1954).…”

Section: Discussionmentioning

confidence: 99%

The Metabolism of Foreign Compounds in the Cestode,Moniezia expansa, and the Nematode,Ascaris lumbricoidesvarsuum

Douch

Blair

1975

Xenobiotica

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1. The ability of the cestode Moniezia expansa and the nematode Ascaris lumbricoides var suum to metabolize foreign compounds has been assessed. 2. Both species were unable to oxidase aldrin, aniline, biphenyl, butylbenzene and nitrobenzene or to demethylate aminopyrine, and 4-nitroanisole. 3. M. expansa and A. lumbricoides var suum readily induced 4-nitroanisole, nitrobenzene, 4-nitrobenzoic acid and 4-nitrophenol to the corresponding amines. Azobenzene, dimethylaminoazobenzene, and 1,2-dimethyl-4-(4-carboxyphenylazo)-5-hydroxybenzene were also reduced. 4. Hydrolysis of esters, acetanilide, acetylsalicylic acid, aryl sulphates and aryl phosphates took place readily. However, beta-glucuronides were not hydrolysed. 5. The following reactions were not detected in either species: phosphate, sulphate, beta-glucuronide or beta-glycoside conjugation of phenolic compounds; acetylation of amino compounds, or the formation of glycine conjugates with 4-aminobenzoic acid or benzoic acid. 6. Male nematodes showed a higher rate of drug metabolism than female nematodes.

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Section: Discussionmentioning

confidence: 99%

The Metabolism of Foreign Compounds in the Cestode,Moniezia expansa, and the Nematode,Ascaris lumbricoidesvarsuum

Douch

Blair

1975

Xenobiotica

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“…1, 2, 3 consecutive numbering of activities. 15 with not more than 80g of cells a column (3.9 χ 40 cm) was operated at 4 °C at a flow of 100 m//h. For the gradient (2 χ 800 m/) potassium chloride in the buffer (0.05M phosphate, pH 7.0) was used.…”

Section: Methodsmentioning

confidence: 99%

“…La 1 or C. sporogenes, and reductase 1 and synthase 1 as well as ferredoxin-NAD® reductase and ferredoxin-NADP® reductase of C. kluyveri and 2-oxo-acid synthase of δ 10 Relative rate of EPR signal formation 15 1 10 1 C. sporogenes, all of them partially purified by ion exchange chromatography or additional gel filtration, immediately exhibited the signals of the p-nitrobenzoate radical anion. The results are summarized in Table 4.…”

Section: Participation Of 2-oxo-acid Synthases In the Reduction Ofnitmentioning

confidence: 99%

On Nitroaryl Reductase Activities in SeveralClostridia

Angermaier¹,

Simon²

1983

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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“…These fmdings include the increase in host liver wet weight (1, 3), increase of non-tumor body weight during the early period of tumor growth (8), lack of change in glucose-6-phosphatase (8), and decreases in microsomal drug-metabolizing activities and the associated cytochrome P-450 and NADPH-cytochrome c reductase activity (6,22,23). Decreases of the microsomal components were also observed in liver of rats administered extracts of the rapidly growing Walker 256 carcinosarcoma (1 1).…”

Section: Time Course Of Changes In Host Livermentioning

confidence: 99%

Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats

Strittmatter

1979

Experimental Biology and Medicine

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Some tissues of tumor-bearing animals, particularly the liver, are known to differ from the corresponding normal tissues in the levels of certain enzyme activities and the concentrations of associated metabolically active components (1-8). Furthermore, the administration of fractions obtained from tumors to normal animals can elicit similar changes (9-1 l), but it is not yet clear to what degree such changes in host tissues represent the effects of specific directive substances released by the tumor. Some of the reported changes may reflect the pathologic alterations associated with the general deterioration of the host in advanced stages of cancer. Many of the reported changes in host tissues were seen in animals bearing large tumors, so that the metabolic activities of the tumor represented a major part of the host's total metabolism, and the changes in host tissues may have reflected adjustments to the competition and metabolic burdens imposed by the presence of the tumor (12).We have studied the levels of enzyme activities in the livers of hepatoma-bearing rats during a period when the tumor was still small, to minimize the influence of general tumor metabolism per se.' The parameters chosen for study included activities that are associated with various cytoplasmic compartments and that in some hepatomas are present at levels different from the levels in normal liver. The relatively slow-growing transplantable Reuber H-35 hepatoma (13) was used so that tumor effects could be studied for an extended period during which the tumor size did not exceed a small percent of the host animal's body weight. The changes from normal liver in host liver and in tumor were determined, and where the host liver showed significant changes from normal liver, the time course of the changes was followed in host liver during the period of early tumor growth. Controls involving transplants of normal liver were also run to further define the specificity of tumor effects on the host livers. Growing animals were used with the expectation that tumor effects might become discernible sooner than in adult animals.Materials and methods. Female ACl strain rats were obtained from Microbiological Associates at about 4 weeks of age and 70 g weight, and were maintained in our laboratory on a diet of Purina rat pellets and water ad libitum. The Reuber H-35 hepatoma, obtained from a tumor-bearing rat kindly supplied to us by Dr. Melvin Reuber, was maintained in our laboratory by serial transplants in female AC1 rats. Tumors weighing 4-8g were trimmed free of necrotic tissue, minced in sterile 0.9% NaCl solution, and 0.5 ml of mince, containing 100 mg tumor, was implanted by trochar subcutaneously on the back of rats weighing 100-1 15 g and about 6 weeks of age. Some animals received similar implants of minced liver taken from a normal female AC1 rat of the same age. Normal control animals of the same age and weight were injected with 0.9% NaCl solution. The animals were routinely weighed three times a week and just before killing, and tumor sizes ...

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Effect of Vitamin C Deficiency on the Metabolism of Drugs and Nadph-Linked Electron Transport System in Liver Microsomes

Cited by 52 publications

References 21 publications

The Metabolism of Foreign Compounds in the Cestode,Moniezia expansa, and the Nematode,Ascaris lumbricoidesvarsuum

The Metabolism of Foreign Compounds in the Cestode,Moniezia expansa, and the Nematode,Ascaris lumbricoidesvarsuum

On Nitroaryl Reductase Activities in SeveralClostridia

Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats

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