Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial

Behera, Kishore Kumar; Saharia, Gautom Kumar; Hota, Debasish; Sethy, Madhusmita; Srinivasan, Anand

doi:10.4103/nmj.nmj_200_20

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…This comparison study confirm reduced vitamin D level in serum with Hashimoto's thyroiditis cases and show role the level of vitamin D at Hashimoto's thyroiditis development. These results agree with BEHERA, Kishore Kumar, et al 2020 that showed also function and effects of vitamin D in Hashimoto's thyroiditis patients, also demonstrate that vitamin D play as regulation factor in autoimmune disease genes regulation like Hashimoto's thyroiditis disease (10).…”

Section: Resultssupporting

confidence: 91%

relationship between vitamin D and TPO antibody in Hashimoto's thyroiditis

Altaee¹

2022

ijhs

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Introduction: Hashimoto's thyroiditis is autoimmune disease that effect on thyroid gland tissue via penetration some special white blood cells (called lymphocyte) into thyroid gland and it is act to product specific antibodies act to damage the thyroid cells. Vitamin D is fat soluble vitamin, it is from steroid compounds derivatives and act after binding with its receptor in target cell. Vitamin D has many functions, but the important function is regulation factor on gene level, so it include in regulation of autoimmune diseases severity. Objective: This study aimed to explain the role vitamin D deficiency on severity of Hashimoto's thyroiditis via it's effect on TPO-Ab production. Method: The current study involved compare tow groups Hashimoto's thyroiditis with vitamin D deficiency as group 1 and Hashimoto’s thyroiditis without vitamin D deficiency group 2. The serum specimens of all individuals used to measure anti TPO-Ab, T4, TSH and vitamin D levels via TOSOH instrument. Results: This study result's explain after comparison between Hashimoto's thyroiditis with vitamin D deficiency group and Hashimoto's thyroiditis without vitamin D deficiency group the elevation of anti- TPO-Ab levels with sever hypothyroidism in Hashimoto's thyroiditis with vitamin D deficiency group more than other group.

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Section: Resultssupporting

confidence: 91%

relationship between vitamin D and TPO antibody in Hashimoto's thyroiditis

Altaee¹

2022

ijhs

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“…whereas TSH values demonstrated a statistically significant decrease from 7.23 ± 3.16 to 3.04 ± 2.62 mIU/L (p = 0.01) [35].…”

Section: Implications In Hashimoto's Diseasementioning

confidence: 82%

“…Increases in vitamin D levels were statistically significant: from 15.33 ± 5.71 ng/mL to 41.22 ± 12.24 ng/mL. TPO antibody titers illustrated a statistically significant increase from 746.8 ± 332.2 to 954.1 ± 459.8 IU/mL (p = 0.006), whereas TSH values demonstrated a statistically significant decrease from 7.23 ± 3.16 to 3.04 ± 2.62 mIU/L (p = 0.01) [35].…”

Section: Implications In Hashimoto's Diseasementioning

confidence: 91%

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

et al. 2022

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Background and Objectives: Vitamin D deficiency is involved in numerous pathologies, including endocrine pathology. The purpose of this review consists of presenting the role of vitamin D in the pathophysiology of certain endocrine disorders, autoimmune thyroid disorders (Hashimoto’s disease and Grave’s disease), diabetes mellitus, and obesity, and whether its supplementation can influence the outcome of these diseases. Materials and Methods: Review articles and original articles from the literature were consulted that corresponded with the thematic. Results: Vitamin D deficiency is frequently encountered in endocrine disorders and supplementation restores the normal values. In Hashimoto’s disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies. In other studies, supplementation appeared to reduce TSH levels. In Grave’s disease, there was a significant correlation regarding vitamin D levels and thyroid volume respective to the degree of exophthalmos. In diabetes mellitus type 2 patients, supplementation led to some improvement of the HOMA-IR index and HbA1c, whereas obesity data from literature do not report significant beneficial findings. Conclusions: Vitamin D deficiency is highly prevalent in endocrine disorders and its supplementation appears to have numerous beneficial effects.

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“…D3 level and its effects in HT patients and confirm that vit. D3 act as regulation factor on some genes that regulation autoimmune dis-ease such as HT [10].…”

Section: Discussionmentioning

confidence: 99%

Effect study's the role of serum vitamin D3 level in Hashimoto's thyroiditis disease

Al-Dahy¹,

Al-Sammarraie²,

Chaabawi³

2022

Journal of Pharmaceutical Negative Results

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Background: Hashimoto's thyroiditis (HT) is classify within the autoimmune disease of thyroid gland caused by diffuse of special lymphocytes into thyroid, lymphocyte product's special antibody lead to destroy gland tissue . Vitamin D (vit.D) is steroid substance bind with special receptor to have it's functions .Vit.D3 has various function in human body such as non skeletal function of vit.D3 is gene regulation that involve in autoimmune disease.Materials and methods: Present study include collection involved tow groups , HT disease group and healthy individuals , then measured vit.D3 , T4, TSH and anti-TPO levels for all groups.Results: Study result's shown after comparison between HT patients group and control group the reduction of serum vit.D level at HT group with present hypofunction of thyroid gland .Conclustion : Concluded this study to must be serumvit.D3 level within normal rang due to vit.D3 has function to regulation genes that effect on autoimmune diseases such as HT via modulation of immune cells secretions that lead to thyroid cells destroy.

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Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial

Cited by 14 publications

References 15 publications

relationship between vitamin D and TPO antibody in Hashimoto's thyroiditis

relationship between vitamin D and TPO antibody in Hashimoto's thyroiditis

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

Effect study's the role of serum vitamin D3 level in Hashimoto's thyroiditis disease

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