Effect of Vitamin D Supplementation on the Level of Circulating High-Sensitivity C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

Abstract

Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker. Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level. A systematic literature search was conducted in September 2013 (updated in February 2014) via PubMed, Web of Science, and Cochrane library to identify eligible studies. Either a fixed-effects or a random-effects model was used to calculate pooled effects. The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, −2.13, −0.03), with the evidence of heterogeneity. Subgroup analysis suggested a higher reduction of 2.21 mg/L (95% CI, −3.50, −0.92) among participants with baseline hs-CRP level ≥5 mg/L. Meta-regression analysis further revealed that baseline hs-CRP level, supplemental dose of vitamin D and intervention duration together may be attributed to the heterogeneity across studies. In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP. However, the result should be interpreted with caution because of the evidence of heterogeneity.

High-Sensitivity CRP is Associated with Serum 25-Hydroxyvitamin D Levels, but is not Affected by 5-Year Supplementation with Cholecalciferol

“…Recent studies have suggested the role of 25(OH) D in lowintensity chronic inflammation in healthy and T2DM subjects [30,31]. To our knowledge, there have been few RCTs in which inflammatory biomarkers, including hs-CRP, were secondary outcomes [30].…”

“…To our knowledge, there have been few RCTs in which inflammatory biomarkers, including hs-CRP, were secondary outcomes [30]. Our interventional study (the Tromsø vitamin D and T2DM trial) is the only RCT to date with a follow-up period as long as 5 years.…”

Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

“…We conducted his systematic review based on the international referred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines [13,14]. We registed our study in the International Prospective Register of Systematic Reviews, PROSPERO (registration no: CRD42016036932).…”

“…Therfore there is substantial uncertainty about the net effect of vitamin D supplementation on CRP levels. Asystematic study which has addressed this issue dates back to 2014 inlcuding only a few studies [13]. Therefore, a comprehensive evalaution of evidence is needed to achieve an evidence-based conclusion.…”

Экстраскелетные Эффекты Витамина D: Роль В Патогенезе Сердечно-Сосудистых Заболеваний

“…Для определения значимости назначения препаратов витамина D в изме-нении уровня циркулирующего СРБ был проведен ме-таанализ, в который были включены результаты иссле-дований, опубликованных до февраля 2014 г., и пред-ставленные в PubMed, Web of Science и Cochrane library (Chen N. et al, 2014). Для статистической обработки данных было отобрано 10 исследований, объединив-ших 924 участника.…”