Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial

Fang, James C.; Kinlay, Scott; Beltrame, John F.; Hikiti, Hiroyuki; Wainstein, Marco Vugman; Behrendt, Dominik; Suh, Jung Hee; Frei, Balz; Mudge, Gilbert H.; Selwyn, Andrew P.; Ganz, Patricia A.

doi:10.1016/s0140-6736(02)08154-0

Cited by 262 publications

(66 citation statements)

References 31 publications

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“…A large percentage of both CR and comparison subjects were taking a variety of supplements. However, this should not interfere with the interpretation of our findings, because it has been shown that supplementation with antioxidant vitamins does not lower serum lipid and lipoproteins (29)(30)(31)(32)(33)(34) or BP (29). Moreover, a recent study, conducted in more than 20,000 subjects, found that vitamin E, vitamin C, and ␤-carotene supplementation resulted in small but significant increases in plasma Tchol, LDL-C, and TG concentrations (30).…”

Section: Discussionmentioning

confidence: 75%

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

Fontana

Meyer

Klein

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

803

625

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Little is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis. We evaluated the effect of CR on risk factors for atherosclerosis in individuals who are restricting food intake to slow aging. We studied 18 individuals who had been on CR for an average of 6 years and 18 age-matched healthy individuals on typical American diets. We measured serum lipids and lipoproteins, fasting plasma glucose and insulin, blood pressure (BP), high-sensitivity C-reactive protein (CRP), platelet-derived growth factor AB (PDGF-AB), body composition, and carotid artery intima-media thickness (IMT). The CR group were leaner than the comparison group (body mass index, 19.6 ؎ 1.9 vs. 25.9 ؎ 3.2 kg͞m 2 ; percent body fat, 8.7 ؎ 7% vs. 24 ؎ 8%). Serum total cholesterol (Tchol), low-density lipoprotein cholesterol, ratio of Tchol to high-density lipoprotein cholesterol (HDL-C), triglycerides, fasting glucose, fasting insulin, CRP, PDFG-AB, and systolic and diastolic BP were all markedly lower, whereas HDL-C was higher, in the CR than in the American diet group. Medical records indicated that the CR group had serum lipid-lipoprotein and BP levels in the usual range for individuals on typical American diets, and similar to those of the comparison group, before they began CR. Carotid artery IMT was Ϸ40% less in the CR group than in the comparison group. Based on a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis. This interpretation is supported by the finding of a low carotid artery IMT.

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Section: Discussionmentioning

confidence: 75%

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

Fontana

Meyer

Klein

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

803

625

View full text Add to dashboard Cite

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“…Nonenzymatic antioxidants such as vitamins C and E and reduced glutathione are known to be decreased in diabetic state because of their free-radical scavenging property (Garg and Bansal, 2000). The observed decline in the levels of vitamins C and E and reduced glutathione in the liver of STZ-induced diabetic rats (Tables 4 and 5) was due to the decreased capacity of nonenzymatic antioxidants to scavenge the increased production of free radicals (Fang et al, 2002). However, administration of M. citrifolia fruits extract to diabetic rats showed a marked increase in levels of these nonenzymatic antioxidants, thereby diminishing the effects of free radicals in the liver.…”

Section: Weight In Gramsmentioning

confidence: 91%

Biochemical evaluation of antihyperglycemic and antioxidative effects of Morinda citrifolia fruit extract studied in streptozotocin-induced diabetic rats

Rao

Subramanian

2008

Med Chem Res

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The hypoglycemic and antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of Morinda citrifolia fruit at a concentration of 300 mg/kg body weight/rat/ day was orally administered to STZ-induced diabetic rats for a period of 30 days. The elevated levels of blood glucose, glycosylated hemoglobin, blood urea, and serum creatinine in the diabetic rats reverted back to near normal after treatment with the noni fruit extract. Similarly significant decrease in the levels of plasma insulin and hemoglobin were elevated to near normal after treatment with fruit extract, suggesting the antihyperglycemic effect of Morinda citrifolia fruit. Determination of thiobarbituric acid reactive substance (TBARS), hydroperoxides, and both enzymatic and nonenzymatic antioxidants evidenced the antioxidative potential of the extract of noni fruit, which in turn may be responsible for its hypoglycemic potential. Alterations observed in the activities of pathophysiological enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT), and serum alkaline phosphatase (ALP) in the serum of control and experimental groups of rats revealed the tissue protective nature of Morinda citrifolia fruits, and the results of all the biochemical parameters analyzed were comparable with glyclazide, the standard reference drug.

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“…Non-enzymatic antioxidants such as ascorbic acid and E and reduced glutathione are known to be decreased in hyperglycaemic state because of their free radical-scavenging property (Garg and Bansal, 2000). The observed decline in ascorbic acid and E and reduced glutathione levels seen in the liver of STZ-induced diabetic rats (Table 4 and 5) arose on the grounds of the decreased capacity of non-enzymatic antioxidants to scavenge increasingly produced free radicals (Fang et al, 2002). However, the administration of P. americana fruit extract in hyperglycaemic rats resulted in a marked increase in levels of these non-enzymatic antioxidants, thereby diminishing the effects of free radicals in the liver.…”

Section: Groupsmentioning

confidence: 97%

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Rao¹,

Adinew²

2011

Afr. J. Trad. Compl. Alt. Med.

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Insulin-stimulative and anti-oxidative effects of Persea americana fruit extract were evaluated using streptozotocin (STZ). Ethanol extract of P. americana in the concentration of 300 mg/kg body weight/rat /day was orally administered to rats introduced into STZ-induced hyperglycaemic state for a period of 30 days. After the treatment with avocado fruit extract, the elevated levels of blood glucose, glycosylated haemoglobin, blood urea and serum creatinine seen in the hyperglycaemic rats, reverted back to near normal. Similarly, significantly decreased plasma insulin and haemoglobin levels went back to near normal after the treatment, suggesting the insulin-stimulative effect of P. americana fruit. Determination of thiobarbituric acid reactive substances (TBARS), hydroperoxides and both enzymatic and non-enzymatic antioxidants, confirmed the anti-oxidative potential of avocado fruit extract which, in turn, might be responsible for its hypoglycaemic potential. Changes in activities of enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT), and serum alkaline phosphatase (ALP) seen in the control and experimental rats, revealed the tissue-protective nature of Persea americana fruits, while all of the analysed biochemical parameters were comparable to those obtained with gliclazide as a standard reference drug.

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Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial

Cited by 262 publications

References 31 publications

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

Biochemical evaluation of antihyperglycemic and antioxidative effects of Morinda citrifolia fruit extract studied in streptozotocin-induced diabetic rats

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

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