Effect of X-Ray Irradiation on Muscle Fatigue in Rats

Abstract

With the Ingle fatigue test, it has been demonstrated that a loss of muscle responsiveness, increased fatigability and decreased work output follow acute whole body irradiation. These effects increase with time postirradiation. In both normal and irradiated animals, strain differences were observed. In the dosage used, the administration of adrenal cortical extract did not improve performance. Adrenalectomy plus cortical extract did not improve performance. It has been postulated that the poor performance of the irradiated animals is related to a lack of glycogenolysis, poor intestinal absorption of glucose and circulatory collapse.

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…This view is also held by Haley, et al (1958) Another possible effect on activity following rear irra diation might be attributed to a change in hormone output of the interstitial cells of the testes, in view of the sex effect on general activity level which has previously been discussed.…”

“…To determine the effect of X-radiation muscle fatigue and the part played in this response by the adrenal cortical hor mones, Haley _et al ( 1958) Administration of adrenal cortical extract had no effect on either control or irradiated Wistar rats, but increased the work output of both groups in the Long-Evans strain. Adren alectomy failed to alter the differences between control and irradiated animals observed with irradiation alone.…”

“…The effects of the adrenocortical hormones have been discussed by Ramey, et_ al. (1950) and Haley, et al (1958) in relation to the possible influence on muscle fatigue both with and without radiation, and it was concluded that probably the most slgnifi-cant contribution of adrenocortical hormone deficiency to muscle fatigue is the impairment of blood flow, resulting in insufficient energy supplies to the muscles. Concurrent adren aline deficiency would be expected to enhance this effect be cause of its influence on the blood glucose level as well as its many sympathetic actions which could affect muscle fa tigability and activity.…”

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…The fact that irradiation of the rear third of the body results in an activity reduction which is very similar to that caused by mid irradiation tends to further implicate damage to the intestinal tract and the resultant poor glucose absorption as a major contributing factor. This view is also held by Haley, et al (1958) Another possible effect on activity following rear irra diation might be attributed to a change in hormone output of the interstitial cells of the testes, in view of the sex effect on general activity level which has previously been discussed.…”

“…Since it had already been established that with an optimum diet and salt supply adrenalectomized animals have normal amounts of electrolytes and carbohydrates in the blood, liver, and muscles, circulatory involvement is Implied in the effect of adrenalec-tomy on muscle fatigue in vivo; i._e. , there appears to be a failure of neuro-circulâtory adjustment to the more rapid, blood flow needed in vivo in muscular exercise.To determine the effect of X-radiation muscle fatigue and the part played in this response by the adrenal cortical hor mones,Haley _et al ( 1958) administered 600 r acute whole-body radiation (250 pkv, 15 ma, 0.21 mm Gu inherent, 0.5 mm Gu para bolic, and 1.0 mm Al filters, FOB 100 cm, 9.18-10.25 r per min ute) to rats from the Wistar and Long-Evans strains. At vary ing periods after irradiation, groups of animals were anesthe tized and connected to an Ingle muscle fatigue apparatus.…”