Effective Separation of Enantiomers Based on Novel Chiral Hierarchical Porous Metal‐Organic Gels

Abstract

Metal‐organic gel (MOG) matrices with tunable pore sizes ranging from micropore to macropore, derived from microporous metal‐organic coordination polymers (PCPs), has attracted great attention for their enhanced pore accessibility compared with the multifunctional PCP materials themselves. The enhanced pore accessibility of chiral MOGs is especially imperative for mass transfer applications, including enantioseparations and purifications. Here, for the first time, a novel hierarchical porous MOG‐coated SiO2, derived from a chiral metal‐organic coordination polymer, is employed as chiral stationary phase for effective high‐performance liquid chromatography (HPLC) separation of enantiomers. The selected enantiomers with diverse functional groups are all efficiently separated in a few minutes with significantly higher resolution.

Recent progress in the development of chiral stationary phases for high‐performance liquid chromatography

“…Reprinted with permission [200] shell thickness of approximately 500 nm, gave good separation. It is usually difficult to directly coat MOF particles onto the surface of SiO Tang and co-workers prepared a novel hybrid hierarchical porous metal-organic gel (MOG-1)@SiO 2 composite by the sol-gel method and used it as CSP for HPLC separation of enantiomers [204]. Many racemates, including alcohols, amines, ketones, ethers, and organic acids, have been effectively separated on the prepared composite-based column.…”