Effective treatment of papular acantholytic dyskeratosis with oral isotretinoin

Almeida, Hiram Larangeira de; Duquia, RP

doi:10.1111/j.1468-3083.2006.01896.x

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Successful treatments with topical and systemic steroids have been reported, but some report that they are unhelpful 5 . Topical and oral retinoids also have been used with some response in the lesions 13,14 . The most effective treatment appears to be local ablation of the lesion by cryotherapy, electrocautery or excision.…”

Section: Discussionmentioning

confidence: 99%

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Papular acantholytic dyskeratosis of the vulva

Roh¹,

Choi²,

Lee

2009

The Journal of Dermatology

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We describe a 63-year-old woman with an asymptomatic papular eruption on the vulva. Clinically, the lesions showed multiple pin-head-sized whitish papules on the labia major. Histologically, the biopsy specimen showed acantholysis throughout the epidermis with the presence of dyskeratotic cells resembling corps ronds and grains, hyperkeratosis and parakeratosis. These clinical and histological findings were consistent with the diagnosis of papular acantholytic dyskeratosis of the vulva which is a rare disorder, first described in 1984.

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Section: Discussionmentioning

confidence: 99%

“…5 Topical and oral retinoids also have been used with some response in the lesions. 13,14 The most effective treatment appears to be local ablation of the lesion by cryotherapy, electrocautery or excision. However, because the lesion is not harmful or progressive, accurate diagnosis with reassurance may be enough for the patients.…”

Section: Discussionmentioning

confidence: 99%

Papular acantholytic dyskeratosis of the vulva

Roh¹,

Choi²,

Lee

2009

The Journal of Dermatology

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“…Topikal ve oral retinoidler de tedavide kullanılmaktadır (11). En etkili tedavi biçimi lezyonun kriyoterapi, elektrokoter ile ablasyonu veya cerrahi eksizyonudur (4).…”

Section: şEkilunclassified

Papular acantholytic dyskeratosis of vulva

Yilmaz¹,

Ersöz²

2018

JCurrPath

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ÖZETAmaç: Papüler akantolitik diskeratozis nadir görülen kronik bir deri hastalığı ve klinikopatolojik bir antitedir. Genelde anogenital ve genitokrural bölgede cilt renginde veya beyazımsı papüller şeklinde kendini gösterir. Genç kadınlarda vulvada persistan papüler lezyon olarak klinik bulgu verir. Persistan olmasına rağmen asemptomatiktir.Olgu: 62 yaşında kadın hastada sağ labium majus lateralinde yaklaşık 0,3 cm çaplı büllöz karakterde tek bir lezyon izlendi. Histopatolojik incelemede hiperkeratoz ve akantoz yanı sıra akantoliz ve 'corps rond' ve 'grain' tipinde diskeratotik hücreler tespit edildi. Histopatolojik ve klinik bulgular eşliğinde olguya papüler akantolitik diskeratozis tanısı verildi.Sonuç: Ayırıcı tanıda Hailey-Hailey ve Darier hastalığı başta olmak üzere verrüköz diskeratom ve Grover hastalığı yer almaktadır. Lezyonun klinik olarak özellikleri, lokalize veya yaygın oluşu, aile öyküsü ve genetik mutasyonlar ayırıcı tanıda önemlidir.Anahtar Sözcükler: Diskeratozis, Anogenital, Genitokrural, Papüler akantolitik diskeratozis ABSTRACT Aim: Papular acantholytic dyskeratosis is a rare, chronic skin disorder and clinicopathological entity. It usually manifests with skin-colored or whitish papules on the anogenital and genitocrural area. Clinically, this disease presents as a persistent papular lesion on the vulva of young women. Despite being persistent, it is asymptomatic. Case:A 62-year-old female patient was found to have a 0,3 cm single, bullous lesion over the right labium majus. Histopathological examination revealed hyperkeratosis and acanthosis as well as acantholysis and dyskeratotic cells forming corps rond and grains. Papular acantholytic dyskeratosis was diagnosed with histopathological and clinical findings. Conclusion:Differential diagnosis includes mainly Hailey-Hailey and Darier's diseases as well as verrucous dyskeratoma and Grover's disease. Clinical features of the lesion, presents in a localized or generalized form, family history and genetic mutations are important in differential diagnosis.

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Successful Management of Papular Acantholytic Dyskeratosis Using Carbon Dioxide Laser: A Case Report and Literature Review

Cesari

Shier³

2017

J Low Genit Tract Dis

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Effective treatment of papular acantholytic dyskeratosis with oral isotretinoin

Cited by 3 publications

References 9 publications

Papular acantholytic dyskeratosis of the vulva

Papular acantholytic dyskeratosis of the vulva

Papular acantholytic dyskeratosis of vulva

Successful Management of Papular Acantholytic Dyskeratosis Using Carbon Dioxide Laser: A Case Report and Literature Review

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