Effectively managing wound exudate

Chamanga, Edwin

doi:10.12968/bjcn.2015.20.sup9.s8

Cited by 23 publications

(9 citation statements)

References 2 publications

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“…This allows the absorption of the wound exudates, which is mainly secreted from infected wounds. As wound exudate management is important for allowing wound healing processes to occur, the capacity to absorb and retain wound exudates is an important wound-dressing attribute [30,31]. The presence of the cuprous oxide microparticles in this layer prevents the proliferation of the absorbed bacteria secreted from the wound, suggesting reducing the risk of cross-contamination and foul odor.…”

Section: Discussionmentioning

confidence: 99%

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Borkow¹,

Roth²,

Kalinkovich³

2022

Microbiology Research

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Copper has intrinsic antimicrobial properties. Wound dressings impregnated with cuprous oxide microparticles (hereafter termed COD) have been cleared for the management of acute and chronic wounds by the FDA and other regulatory bodies. The COD reduced the viable microbial titers of a wide spectrum of microbes by more than 10,000-fold (4-logs) within 3 h of exposure at 37 °C (p < 0.001). Similar microbial titer reductions were achieved by 3-year naturally aged COD dressings, showing the stability of the biocidal efficacy over time. The potent biocidal efficacy of the COD was maintained even after 7 daily consecutive inoculations of the dressings with ~106 CFU. COD with an adhesive contour blocked the passage of bacteria from the exterior environment to the wound bed side of the dressing even after 7 daily consecutive inoculations of different bacteria on the outer surface of the dressings. Taken together, the study demonstrates the wide spectrum potent in vitro biocidal efficacy of the cuprous oxide impregnated dressings against a wide panel of microorganisms.

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Section: Discussionmentioning

confidence: 99%

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Borkow¹,

Roth²,

Kalinkovich³

2022

Microbiology Research

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“…Longitudinal changes in metalloproteinase levels in ocular adnexal tissues after trauma are indicative of their possible involvement in the wound healing process as a marker of inflammatory activity and degradation of the extracellular matrix as a result of tissue damage [6,7]. MMP-2 and MMP-9 are involved in degradation of type IV collagen, a major component of the basement membrane.…”

Section: Discussionmentioning

confidence: 99%

Monitoring MMP-2 and MMP-7 levels in traumatic wounds of the ocular adnexa

Петренко¹,

Korniienko²,

Hrytsai³

2021

Oftalmol Zh

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Background: Matrix metalloproteinase (MMP)-2 and MMP-9 are gelatinases involved in many physiological and pathological processes including inflammation and angiogenesis, which make up the basis for tissue remodeling and repair. Prolonged inflammation and delay in healing of traumatic wounds result in postoperative cicatricial deformities. MMP-2 and MMP-9 activity monitoring might be a biomarker for healing of traumatic ocular adnexal wounds. Purpose: The purpose of the study was to assess MMP-2 and -9 levels in tissues in traumatic ocular adnexal wounds at various times after trauma. Material and Methods: We examined 60 patients presenting with traumatic ocular adnexal wounds one hour to three months after trauma. Tissue biopsy was obtained during surgical debridement of wounds and frozen. The main study group included samples of traumatized ocular adnexal tissue, and the control group, samples of healthy ocular adnexal tissue obtained during blepharoplasty. The levels of MMP-2 and MMP-9 were assessed by enzyme-linked immunoassay (ELISA). The absorbance of each well was read at a wavelength of 450 nm with a Multiskan FC plate reader, and the mean absorbance was calculated for each reference standard and sample. Samples of patients presenting with traumatic ocular adnexal wounds one hour to three months after trauma were compared with controls with regard to optical density. Results: MMP-2 and MMP-9 levels were higher in biopsy samples from traumatic wounds than in control samples. ELISA analysis found that the peak MMP-2 expression was observed at day 3 after trauma, and was 85% above the level in control samples. From day 7 to day 15, this early peak fell to a level close to (15% higher than) that of day 1. From day 15 to day 21, there was a 35 percent increase in MMP-2 expression. MMP-9 expression levels were significantly higher than MMP-2 expression levels. The peak MMP-9 expression was observed at day 4 after trauma, and was 155% above the level in control samples. From day 4 to day 7, MMP-9 expression decreased to a level 85% above the level in control samples. Thereafter, MMP-9 expression increased again to a level 100% above the level in control samples from day 8 to day 15, and gradually decreased from day 15 to day 21. Conclusion: Our study of MMP-2 and -9 levels in tissues in traumatic ocular adnexal wounds at various times after trauma demonstrated that the peak MMP-2 expression was observed at day 3, and the peak MMP-9 expression, at day 4 after trauma. The levels of both enzymes decreased at day 7, and varied thereafter. By day 21, MMP-2 and MMP-9 levels in samples taken from the wound were as low as the levels in control samples.

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“…The choice and access to advanced covers allow for less frequent dressing changes that benefit the patient with accelerated healing, reduced pain, exudate, and odor 10,11 .…”

Section: Discussionmentioning

confidence: 99%

Custos do tratamento de lesões cutâneas na Atenção Primária à Saúde

Cortez

Moraes

Ferreira

et al. 2020

ESTIMA, Braz. J. Enterostomal Ther.

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Objetivo: Comparar o custo na realização de curativos com o uso de coberturas convencionais e avançadas na Atenção Primária à Saúde. Método: estudo longitudinal retrospectivo realizado em um município de médio porte do interior de Minas Gerais, Brasil, que acompanhou 15 pacientes da admissão à cicatrização das lesões cutâneas para o cálculo dos custos do tratamento. Comparou-se o tratamento realizado anteriormente até o momento da admissão na pesquisa processando o tempo e materiais gastos com o tratamento atual realizado com coberturas avançadas. Resultados: no tratamento convencional, constatou-se tempo médio de 620 dias de existência da lesão anterior à admissão no estudo. Com a troca diária do curativo convencional, o custo estimado total de todos os pacientes foi no valor de R$ 101.030,58 (US$ 26.586,94). Na modalidade de tratamento com coberturas avançadas, o tempo médio de acompanhamento foi de 151 dias, o que resultou em um custo total de R$ 15.631,02 (US$ 4.113,43). A economia foi de mais de R$ 85.000,00 (US$ 22.370,00). Conclusão: o custo do tratamento com coberturas avançadas foi sete vezes menor para o município, além de diminuir o tempo de cicatrização para os pacientes permitindo retorno mais breve para suas atividades laborais.

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Effectively managing wound exudate

Cited by 23 publications

References 2 publications

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Monitoring MMP-2 and MMP-7 levels in traumatic wounds of the ocular adnexa

Custos do tratamento de lesões cutâneas na Atenção Primária à Saúde

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