Effectiveness and safety of Chinese herbal medicine Xiaoyao san for the treatment of insomnia

Abstract

Background: Insomnia is one of the most common sleep problems, which can impact physical and mental quality of life, resulting in a heavy social and economic burden. Xiaoyao san, a Chinese Herbal Medicine product, has been widely used as an alternative to recommended treatments for insomnia, but still lack of evidence of evidence-based medicine, which the clinical efficacy and its safety are questioned. Accordingly, we provide a protocol to evaluate the efficacy and safety of Xiaoyao san to update the search and evaluation for the best available and security treatment for insomnia. Methods: This review systematic and comprehensive retrieves of 8 related databases at home and abroad. Only randomized controlled trials (RCTs) of Xiaoyao san on Insomnia published in English and Chinese will be included. The quality of the included trials including randomization, allocation concealment, blinding, withdrawal, and loss of follow-up which was evaluated using internationally accepted evaluation criteria. And then systematically comprehensive analysis of the efficacy. Results: This review will be to assess the efficacy and safety of Xiaoyao san for insomnia. Conclusion: This systematic review will provide strong evidence for the effectiveness and safety of Xiaoyao san in the treatment of insomnia. PROSPERO registration number: CRD42019127326

Clinical efficacy and safety of traditional Chinese medicine Xiao Yao San in insomnia combined with anxiety

“…[51][52][53] In 6 studies, modified XYS combined with WM was applied to patients in the experimental group, and WM alone was used in the control group. [54][55][56][57][58][59]…”

“…The methodological qualities of the 9 studies are summarized in Table 2. With regard to the generation of random sequences in 9 RCTs, the risk of bias of 5 studies was assessed as low, [55][56][57][58][59] among which the random number table of one study was generated by computer software. [55] The risk of bias of the remaining 4 studies was assessed as "unclear" due to reports that just mentioned "random" but provided insufficient information regarding the methodology of random sequence generation.…”

“…[ 21 ] In TCM, insomnia and anxiety are classified as “insomnia” and “depression syndrome,” according to their clinical manifestations. [ 22 , 23 ] TCM has a long history of treating insomnia combined with anxiety. TCM scholars of successive dynasties have accumulated rich clinical practical experience that is focused on treating many diseases based on syndrome differentiation from the perspective of people's overall concept.…”

“…Therefore, in view of the limitations of the above treatment methods, traditional Chinese medicine (TCM) therapy may be an effective alternative and complementary therapy [21] . In TCM, insomnia and anxiety are classified as “insomnia” and “depression syndrome,” according to their clinical manifestations [22,23] . TCM has a long history of treating insomnia combined with anxiety.…”

Chemical Diversity and Prediction of Potential Cultivation Areas of Cistanche Herbs

“…Medicinal herbs are the material base of traditional medicine in addition to acupuncture and manipulation. The accurate usage and combination of different herbs determine the ultimate efficacy of traditional medicine 1–3 . In addition, the content and type of active components in herbs fluctuate with their botanical origins and growth environments.…”