Effectiveness of Bion Tears, Cellufresh, Aquasite, and Refresh Plus for Moderate to Severe Dry Eye

Protecting the Ocular Surface and Improving the Quality of Life of Dry Eye Patients: A Study of the Efficacy of an HP-Guar Containing Ocular Lubricant in a Population of Dry Eye Patients

“…Typically, however, these preparations provide only short-term relief due to relatively brief ocular retention times. 13 Their high viscosity can also cause blurring of vision upon instillation and may lead to the crusting of dried material on the eyelids. In recent years, conventional artifi cial tears, based primarily on cellulose derivatives, have been supplemented by a wide range of ocular lubricants.…”

“…13 Artifi cial tear treatment is mainly palliative and focused on reducing the symptoms of discomfort to improve the quality of life for a patient. In addition, artifi cial tear treatment aims to develop a physical-chemical protective barrier to limit the epithelial damage typical of this disease.…”

The conjunctival epithelium in dry eye subtypes: Effect of preserved and non-preserved topical treatments

“…This study did not aim to compare ocular surface changes following Cellufresh versus Refresh, although there is evidence that Cellufresh is more effective than Refresh in the restoration of ocular surface in dry eye subjects. 27,28 The results of this study indicate that non-preserved artificial tear supplements alone do not reduce the inflammation associated with dry eye conditions. Treatment strategies for dry eye should be aimed at reducing inflammation on the ocular surface.…”

“…43,44 Reversal of conjunctival squamous metaplasia 27,28 and regeneration of goblet cells 29 with regular use of topical non-preserved artificial tear supplements has been reported. However the results of this study indicate that a four times per day dosing schedule of non-preserved polyvinyl alcoholor carboxymethyl cellulose-based artificial tear supplement used for at least three months did not significantly reduce the N/C or increase goblet cell density compared to an untreated dry eye group of similar severity.…”

“…25 Whilst there has been a shift towards the use of non-preserved artificial tear supplements in the treatment dry eye related ocular surface disease, 26 there is still only limited evidence to support the reversal of conjunctival squamous metaplasia through use of non-preserved artificial tear supplements. [27][28][29] In recent years, recommendations have been made for the adjunctive use of topical anti-inflammatory, [30][31] and anti-allergy agents 17 in the management of dry eye related ocular surface disease that is unresponsive to treatment with artificial tear supplements alone.…”