Effectiveness of Dayak (Eleutherine palmifollia (L) Merr) Extracts Against Escherichia coli In Vitro

Mahmudah, Siti; Muntaha, Akhmad; Muhlisin, Ahmad

doi:10.35916/thmr.v1i2.8

Cited by 4 publications

(3 citation statements)

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“…Meanwhile, a mild inhibitory activity was recorded against S. aureus and P. aeruginosa with MIC values of 25 µg/mL as compared to the positive control, chlarithromycin. Similarly, a research performed by Mahmudah et al [42] indicated that the water extract of the E. palmifolia bulb inhibited the growth of E. coli significantly, with an inhibition diameter of 6 mm at the lowest concentration of 10% and 30 mm at the highest concentration of 100% as compared to the positive control, ceftriaxone (35 mm).…”

Section: Anti-bacterial Propertiesmentioning

confidence: 80%

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

Kamarudin

Sayuti

Razak

et al. 2021

IJMS

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Natural product is an excellent candidate for alternative medicine for disease management. The bulb of E. bulbosa is one of the notable Iridaceae family with a variety therapeutic potential that is widely cultivated in Southeast Asia. The bulb has been used traditionally among the Dayak community as a folk medicine to treat several diseases like diabetes, breast cancer, nasal congestion, and fertility problems. The bulb is exceptionally rich in phytochemicals like phenolic and flavonoid derivatives, naphthalene, anthraquinone, and naphthoquinone. The electronic database was searched using various keywords, i.e., E. bulbosa, E. americana, E. palmifolia, E. platifolia, and others due to the interchangeably used scientific names of different countries. Scientific investigations revealed that various pharmacological activities were recorded from the bulb of E. bulbosa including anti-cancer, anti-diabetic, anti-bacterial, anti-fungi, anti-viral, anti-inflammatory, dermatological problems, anti-oxidant, and anti-fertility. The potential application of the bulb in the food industry and in animal nutrition was also discussed to demonstrate its great versatility. This is a compact study and is the first study to review the extensive pharmacological activities of the E. bulbosa bulb and its potential applications. The development of innovative food and pharma products from the bulb of E. bulbosa is of great interest.

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Section: Anti-bacterial Propertiesmentioning

confidence: 80%

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

Kamarudin

Sayuti

Razak

et al. 2021

IJMS

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“…Indications of the content of Eleutherine Americana Merr extricates from hytochemical screening results containing: flavonoids, saponins, tannins, triterpenoids, alkaloids, anthraquinones, naphthoquinones, and steroids [16,17]. Dayak onions have been displayed to have antioxidant [18,19], antifungal [20] antimitotic [21] and antiacne [22].…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effects of Eleutherine Americana Merr against lead acetate-induced cytotoxicity in mice BALB/C

Jayanti¹,

Said

Choo

et al. 2023

ITEGAM

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Lead is a poisonous metal, hurtful to most human body organs if exposure surpasses a permissible level of 50 µg/m 3 and an action level of 30 µg/m 3 . This occurs through the initiation of reactive oxygen species (ROS). Studies have indicated that Eleutherine americana Merr contains profound biological properties which protects against cancer cells, decreased in prothrombin level, and vessel vasoconstriction. It will be interesting to study the effect of the plant extract on kidneys exposed to lead acetate. This study aimed to evaluate the nephroprotective effects of Eleutherine americana Merr extract on lead acetate cytotoxicity in mice BALB/c. A total of 25 BALB/c mice were randomly divided into five groups. Group1 was given 0.5% Na-CMC orally while Group 2 was treated orally with 0.075 g/kg body weight lead acetate (Pb(CH3COO)2). Group 3 to 5 was given different dosages of Eleutherine americana Merr of 30, 60 and 120 mg/kg body weight accordingly and simultaneously with Pb(CH3COO)2 . All treatment were for 35 days. Mice were sacrificed after 35 days, blood samples were collected for analysis of creatinine and urea while the kidneys were for histological studies. The levels of creatinine and urea was significantly higher in Pb(CH3COO)2 treated mice (p<0.05). Treatment with the plant extract significantly reduced the level of blood creatinine and blood urea at extract concentration of 30mg/kg body weight (p<0.05). Histology studies of the kidneys showed that Pb(CH3COO)2 caused glomeruli atrophy and tubular destructions. Treatment with the plant extract at dosages of 30 and 60 mg/kg body weight seemed to ameliorate the effect Pb(CH3COO)2 on the structure of the nephrons. Extract of Elutherine americana Merr was shown to have nephroprotective effect against the assault of Pb(CH3COO)2 in mice.

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“…Eleutherine palmifolia (L.) Merr is empirically used to treat infectious diseases. It has been scientifically proven active against Pseudomonas fluorescens (Fransira, Yanuhar and Maftuch, 2019), Shigella dysenteriae (Wicaksono, Runadi and Firmansyah, 2018), and Escherichia coli (Mahmudah, Muntaha and Muhlisisn, 2019). E. palmifolia contains alkaloids, glycosides, flavonoids, phenolics, steroids, and tannins (Harlita, Oedjijono and Asnani, 2018;Mutiah et al, 2019;Limantara et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Screening of Antibacterial Activity of Ethyl Acetate Fraction of Eleutherine palmifolia (L.) Merr Bulbs against Salmonella typhi

Rofida

Jamil

Azhari

2020

Pharm. : j. farm. Indones.

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Typhoid fever is an infection caused by the bacterium Salmonella typhi, spread through contaminated food or water. Typhoid fever can be treated with antibiotics, but at this time some pathogen microbes have been resistant to the available antibiotics. Antimicrobials derived from natural product might be the alternative to overcome antibiotic resistance. Eleutherine palmifolia (L.) Merr is empirically used to treat infectious diseases. E. palmifolia has chemical compounds of alkaloids, glycosides, flavonoids, phenolics, steroids, and tannins. This study aims to evaluate the antibacterial activity of ethyl acetate fraction against S. typhi. E. palmifolia bulbs were subsequently extracted using n-hexane solvents and followed by ethyl acetate solvents. The ethyl acetate fraction was tested for antibacterial activity using the disc diffusion method. The ethyl acetate fraction of E. palmifolia at the concentrations of 8, 6, and 8 mg/paper disc showed the diameters of the inhibition zone of 15.1±3.6, 15.3±3.3, and 16.9±1.9 mm, respectively. The conclusion of this study was the ethyl acetate fraction of E. palmifolia has a strong antibacterial activity against S. typhi.

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Effectiveness of Dayak (Eleutherine palmifollia (L) Merr) Extracts Against Escherichia coli In Vitro

Cited by 4 publications

References 0 publications

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

Nephroprotective effects of Eleutherine Americana Merr against lead acetate-induced cytotoxicity in mice BALB/C

Screening of Antibacterial Activity of Ethyl Acetate Fraction of Eleutherine palmifolia (L.) Merr Bulbs against Salmonella typhi

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