Effectiveness of<i>Allium sativum</i>on Bacterial Oral Infection

Karic, Vesna; Jaiswal, Anupam; Abrahamse, Heidi; Thakur, Abhilasha; Ganeshpurkar, Aditya

doi:10.1002/9781119618973.ch22

Cited by 4 publications

(4 citation statements)

References 72 publications

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“…Bacteria find a predominant place in Oral microflora and causes dental caries, periodontitis, gingivitis, tooth decay and ultimately tooth loss [ 131 ]. Although synthetic agents’ chlorohexidine and antibiotics are widely used clinical solutions, associated side effects and rising antibiotic resistance have become serious health concerns [ 132 ].…”

Section: Oral Pathologies and Beneficial Role Of Ge In The Alleviationmentioning

confidence: 99%

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Sasi

Kumar

et al. 2021

Antioxidants

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Garlic (Allium sativa L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases.

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Section: Oral Pathologies and Beneficial Role Of Ge In The Alleviationmentioning

confidence: 99%

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Sasi

Kumar

et al. 2021

Antioxidants

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“…The evidence outlined above suggesGng that the Industrial RevoluGon provided many opportuniGes for oral bacterial communiGes to adjust their composiGon or funcGon could also suggest that there may have been opportuniGes for oral bacterial species to develop ARGs. Increased availability of personal hygiene products such as soap (Pears 1859) and foodstuffs with anGbacterial properGes such as garlic (Petrovska and Cekovska 2010;Karic et al 2020) could have contributed to an environment of increased selecGve pressure for microbial species during the Industrial RevoluGon. This, in turn, would lead to an increased rate of AMR in bacterial communiGes as they fight to survive in the new, harsher environment.…”

Section: The Industrial Revolugonmentioning

confidence: 99%

Inferring diet, disease, and antibiotic resistance from the ancient oral microbiome

Dahlquist-Axe,

Standeven,

Speller

et al. 2023

Preprint

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The interaction between a host and its microbiome is an area of intense study. For the human host, it is known that the various body site-associated microbiomes impact heavily on health and disease states. For instance, the oral microbiome is a source of various pathogens and potential antibiotic resistance gene pools. The effect of historical changes to the human host and environment to the associated microbiome, however, is less explored. In this review, we characterize several historic and prehistoric events which are considered to have impacted the oral environment and therefore the bacterial communities residing within. The link between evolutionary changes to the oral microbiota and the significant societal and behavioral changes occurring during the pre-Neolithic, Agricultural Revolution, Industrial Revolution, and Antibiotic Era is explored. While previous studies suggest the functional profile of these communities may have shifted over the centuries, there is currently a gap in knowledge that needs to be filled. Biomolecular archaeological evidence of innate antimicrobial resistance within the oral microbiome shows an increase in the abundance of antimicrobial resistance genes since the advent and widespread use of antibiotics in the modern era. Nevertheless, a lack of research into the prevalence and evolution of antimicrobial resistance within the oral microbiome throughout history hinders our ability to combat antimicrobial resistance in the modern era.

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“…Moreover, in vivo studies have demonstrated that mouth rinse having garlic extract is capable to cure of Streptococcus mutans bacteria by falling their total count within saliva. A partial interest in garlic as an oral antibacterial agent has developed as it appears that the bacterial resistance to garlic is much less than usual antibiotics [ 107 ].…”

Section: Medicinal Plants Used To Treat Gingivitis and Periodontitismentioning

confidence: 99%

Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis

Rani

Singla

Narwal³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world’s population. Gingivitis is a very common, nondestructive inflammatory disease of gums that causes redness and irritation of the gingiva (gums), but periodontitis causes permanent damage to teeth’ subsidiary structures. Herbal medicines are getting popular for the treatment of such types of disorders due to being economical with their medicinal effectiveness, compatibility, and nontoxicity. Traditional chemical therapies can cause cell toxicity along with their disease-curing effects. In this article, we discussed the medicinal plants that can be used as an alternative for the treatment of gingivitis (early-stage gum disease) and periodontitis (chronic-stage gum disease).

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Effectiveness ofAllium sativumon Bacterial Oral Infection

Cited by 4 publications

References 72 publications

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Inferring diet, disease, and antibiotic resistance from the ancient oral microbiome

Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis

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