Effectiveness of tobramycin conjugated to iron oxide nanoparticles in treating infection in cystic fibrosis

Brandt, Yekaterina I.; Armijo, Leisha M.; Rivera, Antonio C.; Plumley, John B.; Cook, Nathaniel C.; Smolyakov, Gennady A.; Osiński, Marek

doi:10.1117/12.2009549

Cited by 6 publications

(4 citation statements)

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“…This dry powder formulation has been shown to have a shorter administration time, increased patient adherence and overall satisfaction than TIS [16,17]. Previous studies have shown improved delivery of tobramycin through thick mucus and enhanced treatment of planktonic P. aeruginosa via conjugating its amino groups with carboxyl groups of citric acid-coated magnetic nanoparticles [18,19].…”

Section: Tobramycinmentioning

confidence: 98%

Successes and Challenges: Inhaled Treatment Approaches Using Magnetic Nanoparticles in Cystic Fibrosis

2020

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Magnetic nanoparticles have been largely applied to increase the efficacy of antibiotics due to passive accumulation provided by enhancing permeability and retention, which is essential for the treatment of lung infections. Recurring lung infections such as in the life-shortening genetic disease cystic fibrosis (CF) are a major problem. The recent advent of the CF modulator drug ivacaftor, alone or in combination with lumacaftor or tezacaftor, has enabled systemic treatment of the majority of patients. Magnetic nanoparticles (MNPs) show unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. These properties make them suitable to be used as drug carriers and hyperthermia-based agents. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. The benefits of delivering CF drugs via inhalation using MNPs as drug carriers afford application of sufficient therapeutic dosages directly to the primary target site, while avoiding potential suboptimal pharmacokinetics/pharmacodynamics and minimizing the risks of systemic toxicity. This review explores the multidisciplinary approach of using MNPs as vehicles of drug delivery. Additionally, we highlight advantages such as increased drug concentration at disease site, minimized drug loss and the possibility of specific cell targeting, while addressing major challenges for this emerging field.

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Section: Tobramycinmentioning

confidence: 98%

Successes and Challenges: Inhaled Treatment Approaches Using Magnetic Nanoparticles in Cystic Fibrosis

2020

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“…In addition, nanoparticles of several antibiotics were also formulated to achieve high stability and activity against diseases. Antibiotic Tobra mycin conjugated to Fe 3 O 4 (iron oxide) nanoparticles was investigated against Pseudomonas aeruginosa in cystic fibrosis diseases (Brandt et al 2013).…”

Section: Amps Delivery Systemmentioning

confidence: 99%

d-Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance

Kapil

Sharma

2021

Can. J. Microbiol.

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Antimicrobial resistance is one of the leading challenges in the human healthcare segment. Advances in antimicrobial resistance has trigger to explore naturally occurring alternatives to stabilize its seriousness. Antimicrobial peptides are small positively charged oligopeptides and are equally potent as that of commercially available antibiotics against broad class of organisms such as Gram-positive bacteria, Gram-negative bacteria, viruses and fungal strains. Along with this, they possess anticancerous activity, activates immune response and regulates inflammation. Peptides have discrete mode of action and fall into various categories due to their amino acid composition. Although Antimicrobial peptides specifically target bacterial cytoplasmic membrane but they can also target their nucleus and protein synthesis as well. Due to increasing demand of novel treatment therapy against brooding antimicrobial resistance, naturally synthesized peptides are a beneficial concept of development. Antimicrobial peptides are pervasive and can be easily modified using de-novo synthesis technology. Antimicrobial peptides can be isolated from natural resources such as humans, plants, bacteria and fungi. This review gives a brief over antimicrobial peptides and its diastereomeric composition. Further current trends and future scope associated with antimicrobial peptides and role of D-amino acids is also discussed with specific emphasis on the design and development of new drugs.

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“…Other pulmonary diseases, such as cystic fibrosis (CF) and tuberculosis (TB), can also benefit from NP-based diagnostic and treatments [ 635 , 636 , 637 , 638 ]. For instance, in CF, conjugation of IONPs with appropriate antibiotics could enhance drug delivery through the mucus and biofilm to bacterial infections, which commonly occurs in CF [ 639 ]. Further studies demonstrated the possibility of magnetic targeting of aerosols, in which drugs of choice can be enriched with dose accuracy into diseased lung regions, thereby reducing undesirable side effects [ 640 ].…”

Section: Other Soft Tissue Regeneration and Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Effectiveness of tobramycin conjugated to iron oxide nanoparticles in treating infection in cystic fibrosis

Cited by 6 publications

References 0 publications

Successes and Challenges: Inhaled Treatment Approaches Using Magnetic Nanoparticles in Cystic Fibrosis

Successes and Challenges: Inhaled Treatment Approaches Using Magnetic Nanoparticles in Cystic Fibrosis

d-Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

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