Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

Abstract

The results suggest that EEVS is effective as a topical anti-inflammatory agent in acute and chronic inflammatory processes and that its action is markedly influenced by the inhibition of neutrophil migration into inflamed tissue as well as by epidermal hyperproliferation.

Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation

“…The cytokines released by activated T lymphocytes promote activation of macrophages, which initiates an acute inflammatory response through the release of TNF-α, IL-1, chemokines, prostaglandins and leukotrienes 44 . Oxazolone is a strong contact sensitizer that induces delayed-type hypersensitivity (DTH) resembling human allergic contact dermatitis.…”

“…Oxazolone is a strong contact sensitizer that induces delayed-type hypersensitivity (DTH) resembling human allergic contact dermatitis. Oxazolone induces skin sensitization, sustained ear swelling, marked polymorphonuclear and T lymphocyte infiltration by increasing CD8 + T-lymphocyte activity 44, 64. Additionally, TRPV1 receptors have a protective role in the development of oxazolone induced contact dermatitis 43 .…”

“…Six days after sensitization, all the mice were challenged on both sides of the right ears with 10 μL of 0.5% oxazolone solution in acetone and olive oil mixture. The left and right ear thickness was measured at 24 h after challenge using a digital Vernier caliper (Mitutoyo, Japan) 44 . The inhibitory effects of BREAF and dexamethasone on DTH reaction were determined by comparing the intensity of DTH reaction in these groups with that of the control group 42 .…”

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

“…Vernonia scorpioides, popularly known as São Simão herb, is a Brazilian species that grows on poor and deforested soils all over the country and is widely used to treat different skin conditions such as lesions, irritations, ulcers, etc. To confirm the use of the species, Rauh et al [116] evaluated the ethanolic extract of their flowers and leaves against 2 models of ear edema: acute, 12-tetracanoylphorbol acetate and arachidonic acid-induced and in a chronic model (with multiple applications of Croton oil), with evaluation of MPO inhibition. The ethanolic extract reduced dose-dependent edema in both cases, and MPO activity reduced in the acute model and in all evaluated parameters in the chronic model.…”

Production of Wilbrandia ebracteata extract standardized in flavonoids and dihydrocurcubitacin and assessment of its topical anti-inflammatory activity

“…Studies reveal that cucurbitacins have anti-inflammatory, antioxidant and analgesic effects (Menezes et al, 2004;Miró, 2004;Pereira et al, 1996 ;Peters et al, 1997Peters et al, , 1999Peters et al, , 2003Siqueira et al, 2007;Duncan et al, 1996;Konoshima et al, 1995;Lazaris et al, 1997;Miró, 1995;Rauh et al, 2011;Valente, 2004). Flavanoids have suppressing effects on a series of reactive species, thus preventing or reducing the extent of oxidative damage (Klimczak et al, 2007;Oliveira et al, 2009).…”