Effectors of alcohol-induced cell killing in Drosophila

Chen, P.; Tu, Xintao; Akdemir, Fatma; Chew, Su Kit; Rothenfluh, Adrian; Abrams, John

doi:10.1038/cdd.2012.47

Cited by 13 publications

(13 citation statements)

References 41 publications

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“…2009; Chen et al. 2012), disc large 1 ( dlg1 ) regulates complex behaviors including phototaxis and circadian activity (Mendoza‐Topaz et al. 2008), clockwork orange ( cwo ) and Dmel_CG5237 ( unc79 ) also operate in circadian clock neurons to promote rhythmic behavior (Richier et al.…”

Section: Resultsmentioning

confidence: 99%

“…There were 11 genes in common between the two studies (Table S5): this overlap was larger than expected of two independent groups but not statistically significant (hypergeometric test: representation factor: 1.3, P = 0.249). Several of these genes have important functions in Drosophila: Phosphogluconate dehydrogenase and cytohesin-1-like are involved in the activation of the mitogen-activated protein kinase (MAPK) (Hahn et al 2013), Juvenile hormone epoxide hydrolase 2 (Jheh2) mediates the catabolism of juvenile hormone (Share and Roe 1988) (but has been co-opted in Apis mellifera to regulate dietary lipid catabolism; Mackert et al 2010), toll like receptor 1 (Toll-1) is an important player in the antimicrobial humoral response and regulation of haemocyte differentiation (Lemaitre et al 1996;Zettervall et al 2004 is involved in apoptosis and response to hypoxia (Azad et al 2009;Chen et al 2012), disc large 1 (dlg1) regulates complex behaviors including phototaxis and circadian activity (Mendoza-Topaz et al 2008), clockwork orange (cwo) and Dmel_CG5237 (unc79) also operate in circadian clock neurons to promote rhythmic behavior (Richier et al 2008;Lear et al 2013), while Formin-like protein (Dmel_CG32138) and Dmel_CG17912 are involved in neurogenesis (Sepp et al 2008;Iyer et al 2013).…”

Section: Transcriptomic Analysis Of Viral Infectionmentioning

confidence: 99%

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Dynamic changes in host–virus interactions associated with colony founding and social environment in fire ant queens (Solenopsis invicta)

Manfredini

Shoemaker²,

Grozinger

2015

Ecology and Evolution

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The dynamics of host–parasite interactions can change dramatically over the course of a chronic infection as the internal (physiological) and external (environmental) conditions of the host change. When queens of social insects found a colony, they experience changes in both their physiological state (they develop their ovaries and begin laying eggs) and the social environment (they suddenly stop interacting with the other members of the mother colony), making this an excellent model system for examining how these factors interact with chronic infections. We investigated the dynamics of host–viral interactions in queens of Solenopsis invicta (fire ant) as they transition from mating to colony founding/brood rearing to the emergence of the first workers. We examined these dynamics in naturally infected queens in two different social environments, where queens either founded colonies as individuals or as pairs. We hypothesized that stress associated with colony founding plays an important role in the dynamics of host–parasite interactions. We also hypothesized that different viruses have different modalities of interaction with the host that can be quantified by physiological measures and genomic analysis of gene expression in the host. We found that the two most prevalent viruses, SINV‐1 and SINV‐2, are associated with different fitness costs that are mirrored by different patterns of gene expression in the host. In fact SINV‐2, the virus that imposes the significant reduction of a queen's reproductive output is also associated with larger changes of global gene expression in the host. These results show the complexity of interactions between S. invicta and two viral parasites. Our findings also show that chronic infections by viral parasites in insects are dynamic processes that may pose different challenges in the host, laying the groundwork for interesting ecological and evolutionary considerations.

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Section: Resultsmentioning

confidence: 99%

Section: Transcriptomic Analysis Of Viral Infectionmentioning

confidence: 99%

Dynamic changes in host–virus interactions associated with colony founding and social environment in fire ant queens (Solenopsis invicta)

Manfredini

Shoemaker²,

Grozinger

2015

Ecology and Evolution

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“…The two metabolic biological processes significantly associated with aggression in previous honey bee studies, oxidation-reduction and inositol biosynthesis (Alaux et al 2009b), are represented in our marker genes (drat and inos, respectively). The drat protein product is involved in ethanol-induced cellular apoptosis (Chen et al 2012), a possible mechanistic connection between ethanol sensitivity and aggression in bees (Ammons & Hunt 2008). inos is the rate-limiting enzyme in inositol biosynthesis (Park et al 2000), a pathway associated with both aggression and depression in mammals (Coupland et al 2005;Taha et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…cyp6g1/2 (which encodes a cytochrome P450 protein) is associated with aggression in D. melanogaster (Drnevich et al 2004) and has been reported to be involved in the biological process oxidation-reduction (Gene Ontology, GO: 0055114). drat also encodes a protein associated with oxidation-reduction (GO: 0055114), but has additional experimental evidence for involvement in response to hypoxia (GO: 0001666; Azad et al 2009) and cellular response to ethanol exposure (GO: 0071361; Chen et al 2012). inos encodes myo-inositol-1-phosphate synthase and is associated with inositol biosynthesis (GO: 0006021) and phospholipid biosynthetic process (GO: 0008654).…”

Section: Brain Gene Expression Aggression Marker Genesmentioning

confidence: 99%

Manipulation of colony environment modulates honey bee aggression and brain gene expression

Rittschof

Robinson

2013

Genes Brain and Behavior

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The social environment plays an essential role in shaping behavior for most animals. Social effects on behavior are often linked to changes in brain gene expression (Robinson et al., 2008). In the honey bee (Apis mellifera L.), social modulation of individual aggression allows colonies to adjust the intensity with which they defend their hive in response to predation threat (Alaux & Robinson, 2007, Couvillon et al., 2008, Hunt et al., 2003). Previous research has demonstrated social effects on both aggression and aggression-related brain gene expression in honey bees, caused by alarm pheromone and unknown factors related to colony genotype (Alaux et al., 2009b). For example, some bees from less aggressive genetic stock reared in colonies with genetic predispositions toward increased aggression show both increased aggression and more aggressive-like brain gene expression profiles (Alaux et al., 2009b, Guzmán-Novoa et al., 2004). We tested the hypothesis that exposure to a colony environment influenced by high levels of predation threat results in increased aggression and aggressive-like gene expression patterns in individual bees. We assessed gene expression using four marker genes. Experimentally induced predation threats modified behavior, but the effect was opposite of our predictions: disturbed colonies showed decreased aggression. Disturbed colonies also decreased foraging activity, suggesting that they did not habituate to threats; other explanations for this finding are discussed. Bees in disturbed colonies also showed changes in brain gene expression, some of which paralleled behavioral findings. These results demonstrate that bee aggression, and associated molecular processes, are subject to complex social influences.

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“…However, cultured cells lacking Drat are protected from ethanol-induced apoptosis, as are Drat-lacking neurons in the fly antennae. Surprisingly, though, flies lacking Drat are sensitive to ethanol-induced sedation, thus showing an uncoupling of cellular sensitivity to toxicity and organismal sensitivity to intoxicating effects (Chen et al, 2012).…”

Section: Gene and Behaviormentioning

confidence: 99%