Effects and Mechanisms of Hemopoiesis-Stimulating Activity of Immobilized Oligonucleotides under Conditions of Cytostatic Myelosuppression

Abstract

Hemopoiesis-stimulating activity of immobilized oligonucleotide preparation was studied on the model of cytostatic myelosuppression induced by injection of cyclophosphamide and 5-fluorouracil. Immobilized oligonucleotides stimulated regeneration of erythro- and granulocytopoiesis in the bone marrow under conditions of cytostatic treatment. The counts of neutrophilic granulocytes and platelets in the peripheral blood increased. The stimulatory effect of the drug was more manifest in animals with active behavior. The mechanism of immobilized oligonucleotide effect was based on stimulation of functional activity of erythroid and granulocytic macrophage precursors.

Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice

“…CP-induced bone marrow toxicity is much harder to treat; strict control of infection and use of intravenous antibiotics, anti-fungal agents, and GM-CSF are some of the preventive approaches [8]. However, the use of GM-CSF and adjuvant therapy is often limited by high costs and serious side effects [13].…”

“…Thus, management of these myelotoxic manifestations becomes an important task in maintaining the wellbeing of patients [12]. Although today hematopoietic growth factors such as granulocyte−macrophage colony-stimulating factor (GM-CSF), erythropoietin (EPO), and thrombopoietin (TPO) are used to accelerate hematopoietic recovery during the course of chemotherapy [1], certain limitations such as secondary myeloid leukemia, convulsion, secondary hypertension, arthralgia, allergic reactions, and high costs often limit their use [13]. Thus, the need for a safe and cost-effective therapeutic molecule that can take care of these situations remains an attractive and hot target for researchers.…”

Steamed Panax notoginseng Attenuates Anemia in Mice With Blood Deficiency Syndrome via Regulating Hematopoietic Factors and JAK-STAT Pathway

“…Hematopoietic cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), erythropoietin (EPO), and thrombopoietin (TPO), are sometimes used to accelerate the hemopoietic recovery during cancer therapy. However, due to the unstable efficacy, high cost, and adverse effects like osteomuscular pain, arthralgia, and allergic reactions (Dygai et al, 2012) caused by those treatments, the applications of above compounds regimens are limited.…”

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice

“…They are recommended to prevent leucopenia (Xu et al, 2011). However, G-CSF only reduces the neutropenia duration for 1–2 days while also increases adverse reactions and the cost of treatment notably (Dygai et al, 2012; Aarts et al, 2013). Traditional Chinese medicine (TCM) formulae have been widely used in China for the treatment of leucopenia (Liu et al, 2014).…”