Effects of a pseudoallergen‐free diet on chronic spontaneous urticaria: a prospective trial

Magerl, Markus; Pisarevskaja, Dina; Scheufele, Ramona; Zuberbier, Torsten; Maurer, Marcus

doi:10.1111/j.1398-9995.2009.02130.x

Cited by 107 publications

(81 citation statements)

References 24 publications

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“…Therefore, higher or lower response rates to LPD may be due to different profiles of urticarial activity in these studies. Recent studies are more detailed about study designs, contents of diets, clinical evaluation criteria and analysis of the results [2,3,12,27]. Nevertheless, it is not possible to compare the response rates of these studies since there are not standardized criterion/criteria for defining ''response''.…”

Section: Discussionmentioning

confidence: 99%

“…Bunselmeyer et al [2] administered a 5-week pseudoallergen-free diet, which caused improvement (reduction of severity of symptoms and increase in quality of life) in 68% of patients with CU. Last, Magerl et al [12] evaluated the response with improvement in urticarial activity score (with wheal and pruritus scores) and dermatology life quality index. 28% of patients were defined as strong and partial responders.…”

Section: Discussionmentioning

confidence: 99%

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Effects of low pseudoallergen diet on urticarial activity and leukotriene levels in chronic urticaria

et al. 2011

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Pseudoallergens and leukotrienes (LTs) may have a role in chronic urticaria (CU). The aim of our study is to evaluate the response to the low pseudoallergen diet therapy in patients with CU and the change in LT levels in diet responsive and non-responsive patients. 34 patients with CU were put on diet for 4 weeks. All patients kept a daily score sheet of pruritus and whealing symptoms. The urticarial activity score (UAS) of each patient was calculated with the sum of pruritus and wheal score. The sum score of the first 7 consecutive days (UAS7-first week) and last 7 days (UAS7-fourth week) were used to compare the clinical outcome of the diet. A reduction of ≥50% in UAS7-fourth week compared to UAS7-first week was considered as "response". Urinary LTE4 (uLTE4) level of each patient was measured at baseline and after the 4 week of diet therapy. 14 of the patients (41.2%) were responsive to diet therapy. Baseline uLTE4 levels were similar between responsive and non-responsive patients (P = 0.540). Second uLTE4 levels (after the 4 week of diet therapy) were significantly lower in responsives than in non-responsive patients (P < 0.001). Second uLTE4 levels of responsives were significantly lower than the baseline values (P = 0.019), whereas this was not significant for non-responsives (P = 0.070). There was a significant correlation between the change in uLTE4 levels and the change in mean urticarial activity scores (r = 0.554, P = 0.001) in the whole study population. In conclusion, low pseudoallergen diet helps to reduce the urticarial activity in CU. The change in urticarial activity correlates with the change in LT levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of low pseudoallergen diet on urticarial activity and leukotriene levels in chronic urticaria

et al. 2011

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“…Besin katkı maddelerinin bazı hastalarda ürtikeri tetiklediği ve/ veya şiddetlendirdiği bilinmektedir (18,27). Kronik spontan ürtikerli hastaların katkı maddesi içermeyen diyetten fayda görmesi, gastrik mukozal permeabilitenin azalması gibi bir kolaylaştırıcı faktörün beraberinde olması ile açıklanmaktadır.…”

Section: Bulgularunclassified

The Etiological Evaluation of Patients with Chronic Urticaria in Childhood

Arıkoğlu¹,

Aydoğdu²,

Batmaz³

et al. 2017

Turkish J Pediatr Dis

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ÖzETAmaç: Kronik ürtikerin etiyolojisi çoğunlukla idiyopatiktir. Çocukluk çağı kronik ürtikeri ile ilgili literatürde sınırlı veri mevcuttur. Çalışmada, çocuklarda kronik ürtikerin etiyolojisinde rol oynayabilecek faktörler ve ilişkili klinik ve laboratuvar bulguların araştırılması amaçlandı. Gereç ve Yöntemler:Kliniğimizde kronik ürtiker tanısı alan 18 yaş altı 80 hasta retrospektif olarak incelendi. Kronik ür-tikerli hastaların klinik özellikleri, laboratuvar bulguları, atopi, enfeksiyon, otoimmünite ve fiziksel ürtikere yönelik tetkikleri değerlendirildi. Bulgular:Kronik ürtiker tanısı ile izlenen 80 hasta çalışmaya dahil edildi. Hastaların ortalama yaşı 10.2±4.1 yıldı. 41'i (%51.2) kızdı. Hastaların %53.7'sinde fiziksel ürtiker, %46.3'ünde kronik spontan ürtiker tesbit edildi. En sık saptanan komorbid hastalıklar sırasıyla; otoimmün hastalık (%10) (5 otoimmün tiroidit, 1 juvenil romatoid artrit, 1 diyabet, 1 akut romatizmal kardit), kronik gastrit veya reflü (%8.7) ve nonsteroidal anti-inflamatuvar ilaç (NSAİ) allerjisi (%5) idi. Kronik ürtikerli hastaların %23.7'sinde atopi, %16.4'ünde helikobakter pylori pozitifliği, %20.3'ünde tiroid otoantikor varlığı, %33.3'ünde antinükleer antikor (ANA) pozitifliği, %25'inde gıda katkı maddesi ile ilişkili ürtiker, %6.7'sinde dışkıda parazit saptandı. Otolog serum deri testi pozitifliği (OSDT) %37.8 olarak bulundu. OSDT pozitif (n=14) ve negatif (n=23) hastalar karşılaştırıldığında; yaş, cinsiyet, atopi, otoimmün hastalık varlığı, ANA pozitifliği, tiroid otoantikor varlığı ve Helikobakter pylori pozitifliği açısından gruplar arasında anlamlı bir fark saptanmadı. Fiziksel ürtiker nedenleri arasında en sık dermografizm (%45) görülürken, %32.4'ünde kolinerjik ürtiker, %8.7'sinde gecikmiş basınç ürtikeri, %8'inde soğuk ürtiker ve %4.7'sinde solar ürtiker tesbit edildi.Sonuç: Çocuklarda kronik ürtiker etiyolojisinde otoimmünite ve fiziksel ürtiker önemli bir yer tutmaktadır. Şüpheli olgularda fiziksel ürtiker testlerinin ve ayrıntılı incelemelerin yapılması kronik ürtikerli olguların daha iyi bir şekilde yönetimine katkı sağlayacaktır.Anahtar Sözcükler: Antinükleer antikor, Çocuklar, Helikobakter pylori, Kronik ürtiker, Otoimmün tiroidit, Otolog deri testi ABSTRAcTObjective: The etiology of chronic urticaria is usually considered idiopathic. There is limited data regarding childhood chronic urticaria in the literature. The aim of the study was to investigate the factors that can play a role in the etiology of chronic urticaria in children and the related clinical and laboratory findings. Material and Methods:We retrospectively evaluated the medical records of 80 children aged under 18 years who attended our clinic and were diagnosed with chronic urticaria. Clinical characteristics, laboratory findings and tests for atopy, infection, autoimmunity and physical urticaria were evaluated.Results: Eighty children with chronic urticaria were enrolled in the study. The mean age of the patients was 10.2±4.1 years. 41 (51.2%) of the patients were female. Of the study population, 46.3...

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“…Some studies have reported an association between CSU and food intolerance. Results of several intervention trials showed that the elimination of “pseudoallergens” from a patient’s diet can reduce the severity of CSU [1, 2]. Guidelines released by the European Academy of Allergy and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA 2 LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) recommend that CSU patients consume a pseudoallergen-free diet for 3 weeks [3].…”

Section: Introductionmentioning

confidence: 99%

Which Fruits and Vegetables Should Be Excluded from a Low-Salicylate Diet? An Analysis of Salicylic Acid in Foodstuffs in Taiwan

Chiang

Venter

Syue

et al. 2018

Int Arch Allergy Immunol

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Background: Eliminating pseudoallergens is an important element of managing chronic spontaneous urticaria (CSU). Salicylic acid (SA) is a primary pseudoallergen in plant-based foodstuffs. Current dietary recommendations are not applicable in East Asia because data on the SA content of many vegetables and fruits commonly consumed in this region are lacking. Methods: We therefore determined the concentration of free SA in 79 popular vegetables and fruits frequently consumed in Taiwan using gas chromatography-mass spectrometry. Results: The SA content ranged from 0.09 to 2.3 mg/kg in the fresh vegetables examined, and from 0.01 to 0.48 mg/kg in the fruits. Conclusions: Data regarding the SA content of East Asian vegetables and fruits could help CSU patients limit their pseudoallergen consumption.

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Effects of a pseudoallergen‐free diet on chronic spontaneous urticaria: a prospective trial

Abstract: Altogether the pseudoallergen-free diet is beneficial for one in three patients. The pseudoallergen-free diet is a safe, healthy and cost-free measure to identify patients with chronic spontaneous urticaria that will benefit from avoiding pseudoallergens.

Cited by 107 publications

References 24 publications

Effects of low pseudoallergen diet on urticarial activity and leukotriene levels in chronic urticaria

Effects of low pseudoallergen diet on urticarial activity and leukotriene levels in chronic urticaria

The Etiological Evaluation of Patients with Chronic Urticaria in Childhood

Which Fruits and Vegetables Should Be Excluded from a Low-Salicylate Diet? An Analysis of Salicylic Acid in Foodstuffs in Taiwan

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