Effects of a structured educational intervention on metabolic control of type-1 diabetes mellitus patients

Endyarni, Bernie; Batubara, Jose Rl; Boediman, I

doi:10.14238/pi46.6.2006.260-5

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…In our study, there were more female subjects (15/26) compared to male subjects (11/26) (female: male ratio was 1,4:1). This baseline characteristic was similar to the national epidemiological data in Indonesia, which stated that the prevalence of type 1 DM in men was less than in women (45:55) [1,12]. However, another study demonstrated that the prevalence of type 1 DM was similar between men and women [13].…”

Section: Baseline Characteristicssupporting

confidence: 86%

“…However, another study demonstrated that the prevalence of type 1 DM was similar between men and women [13]. These differences might be caused by the difference in population, race, and the number of research subjects [12]. Based on the nutritional state, our data showed that the proportion of children with good nutrition status was higher compared to children with low nutrition status.…”

Section: Baseline Characteristicsmentioning

confidence: 62%

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Effect of Vitamin D3 Supplementation on the Level of 25(OH)D3, Osteocalcin, and HbA1c in Children with Type 1 Diabetes Mellitus

Wulandari

Tjahjono²,

Widjajanto³

2022

J.Trop.Life.Science

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Type 1 diabetes mellitus (T1DM) is a chronic disease caused by insulin deficiency resulting from autoimmune destruction of pancreatic beta cells. Increased risk of fractures and osteoporosis in T1DM is associated with reducing osteoblast proliferation, survival, and activity. Osteocalcin (OC) is a marker of late-stage osteoblast differentiation. It might be positively modulated by vitamin D. This study was aimed to investigate the effect of vitamin D3 supplementation on the level of 25(OH)D3, HbA1c, and OC in children with T1DM. A randomized clinical trial was conducted to measures the levels of 25(OH)D3, HbA1c, and OC in children with T1DM supplemented with vitamin D3. Many 26 children with T1DM were equally assigned into two groups: control (standardized insulin treatment) and treatment group (standardized insulin treatment + vitamin D3 2000 IU/day). Subject characteristics showed that the subjects were predominantly female (15/26), well-nourished (19/26), the average age is 12,31 ± 3,069 year, and the dose of insulin average is 1,17 ± 0,233 IU/kg BW/day. Our data demonstrated that vitamin D3 treatment significantly increased the level of 25(OH)D3 and improved glycemic control, represented by a low HbA1c level. However, there was no significant difference in OC level in both groups (independent t-test, p > 0.05). Further analysis showed no significant relationship between the level of 25(OH)D3, HbA1c, and OC. We concluded that vitamin D3 supplementation improves children's glycemic control with T1DM, but no significant alteration on OC levels.Keywords: HbA1c, Osteocalcin, T1DM, Vitamin D

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Section: Baseline Characteristicssupporting

confidence: 86%

Section: Baseline Characteristicsmentioning

confidence: 62%

Effect of Vitamin D3 Supplementation on the Level of 25(OH)D3, Osteocalcin, and HbA1c in Children with Type 1 Diabetes Mellitus

Wulandari

Tjahjono²,

Widjajanto³

2022

J.Trop.Life.Science

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“…16 Hal ini dimungkinkan oleh adanya perbedaan pada jumlah populasi, ras, dan jumlah subjek penelitian. 17 Pubertas merupakan masa transisi antara masa kanakkanak dengan dewasa yang dipengaruhi oleh banyak faktor. Pada saat itu terjadi perubahan fisik dan psikologis karenaaktivitas endokrin.Di Amerika Serikat, kebanyakan anak perempuan akan mengalami pubertas pada usia 8-13 tahun, sedangkan anak lakilaki akan mengalami hal yang sama pada usia 9-14 tahun.…”

Section: Pembahasanunclassified

Pengaruh Pemberian Vitamin D3 Terhadap Kadar Osteokalsin, 25(oh)d Dan Durasi Sakit Pada Diabetes Mellitus Tipe 1 Pada Anak

Setia

Tjahjono

2019

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Diabetes mellitus tipe 1 (DM tipe 1) adalah salah satu penyakit kronik yang sampai saat ini belum dapat disembuhkan. Anak dan remaja dengan T1D (type 1 diabetes) mempunyai risiko osteoporosis dan komplikasi jangka panjang lainnya lebih tinggi daripada anak dan remaja nondiabetik. Kadar 25(OH)D ditemukan lebih rendah pada anak dengan DM tipe 1. Penelitian ini ingin membuktikan bahwa suplementasi vitamin D3 pada anak dengan DM tipe 1 dapat meningkatkan kadar 25(OH)D dan osteokalsin, serta ingin mengetahui hubungan antara durasi sakit terhadap kadar osteokalsin dan 25(OH)D serum. Desain penelitian ini adalah double-blinded randomized controlled trial suplementasi vitamin D3 pada anak dengan DM tipe 1. Sebanyak 26 pasien rawat jalan dengan DM tipe 1 berusia 1-18 tahun berpartisipasi dalam penelitian ini. Pasien kemudian dibagi menjadi 2 kelompok, kelompok kontrol dan kelompok perlakuan, sedangkan durasi sakit dibagi menjadi 2, yaitu kurang dan lebih dari lima tahun. Pasien diberikan vitamin D3 2000 IU tiap hari selama 6 bulan. Hasil penelitian mendapatkan bahwa kadar osteokalsin pada kelompok perlakuan lebih tiggi namun tidak berbeda bermakna dibandingkan dengan kelompok kontrol (p=0,663). Namun, kadar 25(OH)D pada kelompok perlakukan lebih tinggi secara signifikan dibanding dengan kelompok kontrol (p=0,000). Tidak ada korelasi antara durasi penyakit, baik dengan kadar osteokalsin maupun kadar 25(OH)D (p=0,955 dan p=0,203 secara berurutan). Pemberian vitamin D3 selama 6 bulan pada anak dengan DM tipe 1 dapat meningkatkan kadar osteokalsin dan 25(OH)D serum. Durasi penyakit tidak berhubungan dengan kadar osteokalsin dan 25(OH)D setelah suplementasi vitamin D3 selama 6 bulan. Kata kunci: diabetes mellitus tipe 1, durasi penyakit, osteokalsin, vitamin D3

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“…However, based on ISPAD data in the same year mentioned that gender differences to the incidence of T1DM did not occur as a whole worldwide [1]. These differences are due to differences in population, race, and number of research subjects [19].…”

Section: Subject Characteristicsmentioning

confidence: 99%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Effects of a structured educational intervention on metabolic control of type-1 diabetes mellitus patients

Abstract: Background Children with type-1 diabetes face not only short-

Cited by 3 publications

References 19 publications

Effect of Vitamin D3 Supplementation on the Level of 25(OH)D3, Osteocalcin, and HbA1c in Children with Type 1 Diabetes Mellitus

Effect of Vitamin D3 Supplementation on the Level of 25(OH)D3, Osteocalcin, and HbA1c in Children with Type 1 Diabetes Mellitus

Pengaruh Pemberian Vitamin D3 Terhadap Kadar Osteokalsin, 25(oh)d Dan Durasi Sakit Pada Diabetes Mellitus Tipe 1 Pada Anak

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

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