Effects of acetaldehyde on responses of rabbit corpus cavernosal smooth muscle

Kim, Hyung Jee; Sohng, Inho; Lee, Gil‐Ho; Kim, Je Jong; Koh, Seok‐Keun

doi:10.3346/jkms.2000.15.3.295

Cited by 12 publications

(6 citation statements)

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“…Dose‐dependent negative effects of acute administration of ethanol on apomorphine‐induced erections have been reported in rats [235]. In isolated corpus cavernosum, acute exposure to ethanol or its main metabolite decreased nerve‐mediated and bethanechol‐induced relaxations [236,237]. In support of a role for ethanol as a risk factor for cavernosal endothelial damage, electron microscopy of the erectile tissue from mice described nuclear alterations such as reorganization of heterochromatin, appearance of deep nuclear indentations, and a decrease in the number of pinocytotic vesicles [238].…”

Section: Experimental Models Of Pathophysiological Statesmentioning

confidence: 96%

Experimental Models for the Study of Female and Male Sexual Function

Giuliano

Pfaus

Srilatha

et al. 2010

The Journal of Sexual Medicine

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Introduction Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting.

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Section: Experimental Models Of Pathophysiological Statesmentioning

confidence: 96%

Experimental Models for the Study of Female and Male Sexual Function

Giuliano

Pfaus

Srilatha

et al. 2010

The Journal of Sexual Medicine

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“…It was reported that alcohol intoxication decreased testosterone level and caused hyperestrogen and hyperprolectinemia in males, and that hypoandrogen findings were more common in alcohol-addicted males [8]. Wetterling [11]; and Tijanda and Janknegt reported that alcohol addiction caused thiamine deficiency in males and resulted in sexual and erectile disorders [12].…”

Section: Sm-iv (Diagnostic and Statistical Manual Ofmentioning

confidence: 99%

“…reported that alcohol consumption caused penile arterial circulation deficiency [10]; Kim et al. reported that ethanol had an adverse effect on nitric oxide level [11]; and Tijanda and Janknegt reported that alcohol addiction caused thiamine deficiency in males and resulted in sexual and erectile disorders [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Sexual Functions in Turkish Alcohol-Dependent Males

Dişsiz

Öskay

2011

The Journal of Sexual Medicine

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Introduction It was reported that long-term and high amount of alcohol consumption cause sexual dysfunction in men. There is a lack of descriptive studies focusing on the sexual dysfunction of alcohol dependent men in Turkey. Aims This study was conducted to evaluate sexual functions of alcohol dependent men. Methods This descriptive study was performed at the Alcohol and Substance Research Treatment and Education Center (ASRTEC). The data was collected between 26 December 2007 and 26 December 2008. Main Outcome Measures As research instruments, an interview form of 30 questions that questioned personal characteristics and was developed by researchers, and IIEF (International Index of Erectile Dysfunction) with 15 items that evaluated sexual dysfunction were used. Results Mean age of men was 41.22 ± 8.19; 36.5% of participants were graduated from primary school, and 57.5% were unemployed. Average daily alcohol consumption was 16.41 ± 4.90 standard alcohol. We found that 47% of alcohol-dependent men had their first sexual experience before they were 18 years old, 64.4% had multiple partners, 1.7% experienced a sexually transmitted disease, 7.7% had a chronic disease, and 18.3% had pain during intercourse. Mean total IIEF scores of alcohol-dependent men was 57 ± 9.23 (mean ED scores 23.41 ± 3.91). Therefore, 70.3% of participants had a mild (17–25), and 4.4% had a moderate (11–16) erectile dysfunction. With a multivariate analysis, predictors of erectile dysfunction in chronic alcohol dependent male were determined as age of subject, age of onset for alcohol, duration of alcoholism, and cigarette use. Conclusion Chronic alcoholism affects sexual functions in men. Sexual dysfunction in alcohol addicted males is related with education level and unemployment and starting alcohol consumption at an early age and long-term cigarette smoking.

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“…It is well known that after ingestion, ethanol is metabolized sequentially to acetaldehyde, acetate, CO 2 and water. Previously, Kim et al 46 showed that acetaldehyde suppressed neurogenic relaxation induced by transmural EFS in rabbit corpus cavernosum smooth muscle, and noted that increasing acetaldehyde level seen in chronic alcoholism may contribute to male erectile dysfunction mainly by the inhibition of NO formation. Taking these findings together, we speculated that chronic high dose of alcohol consumption impairs the synthesis or availability of NO in corpus cavernosum smooth muscle.…”

Section: --22mentioning

confidence: 99%

Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit

et al. 2012

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Epidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)-and papaverine-induced relaxant responses in the isolated corpus cavernosum tissues from rabbits submitted to an 12-week course of chronic low (5% v/v) or high ethanol intake (30% v/v). Increased carbachol-and EFS-induced relaxant responses but not SNP and papaverine, were observed in low ethanol-fed rabbits compared with controls. However, impaired carbachol-and EFSinduced relaxant responses were observed in high ethanol-fed rabbits compared with control rabbits. There were no significant differences in SNP-and papaverine-induced relaxant responses between control and high ethanol-fed rabbits. In addition, decreased neuronal nitric oxide synthase (nNOS) and endothelial NOS (eNOS) immunoreactivity in penile tissue were found in high ethanol-fed rabbits, but increased the immunoreactivity in low ethanol-fed group, compared with control group. These results suggest that alterations in nitric oxide (NO) production within the cavernous tissue in the high ethanol-fed rabbits are, at least in part, responsible for the erectile dysfunction.

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Effects of acetaldehyde on responses of rabbit corpus cavernosal smooth muscle

Cited by 12 publications

References 0 publications

Experimental Models for the Study of Female and Male Sexual Function

Experimental Models for the Study of Female and Male Sexual Function

Evaluation of Sexual Functions in Turkish Alcohol-Dependent Males

Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit

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