Effects of acetylbergenin against D -galactosamine-induced hepatotoxicity in rats

Lim, Hyun; Kim, Hack Seang; Choi, Hanlim; Oh, Seikwan; Jang, Choon‐Gon; Choi, Jongwon; Kim, Seunghwan; Chang, Myung Jei

doi:10.1006/phrs.2000.0730

Cited by 59 publications

(37 citation statements)

References 23 publications

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“…Lycopene pretreated cells displayed negligible tail movements (d). Lim et al, 2000). An observed increase in tissue GSH content in lycopene pretreated rats suggests that it prevent the tissue depletion of GSH.…”

Section: Discussionmentioning

confidence: 95%

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Abdulazeez

Devaki

2013

Pharmaceutical Biology

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Context: Lycopene is a phytonutrient under considerable investigation for its antioxidant benefits in treating diseases like cancer, cardiovascular diseases, osteoporosis and diabetes. Objective: This study explores the effect of lycopene against oxidative damage during experimental hepatitis, induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS). Materials and methods: Experimental rats were pretreated with lycopene intraperitoneally for 6 d (10 mg/kg body weight/day) and then induced by D-GalN/LPS. After induction, the levels of lipid peroxides in serum and liver of control and experimental group of animals were measured. The activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase and nonenzymatic antioxidants, such as reduced glutathione, vitamin C and vitamin E were also analyzed. The genotoxic effect of D-GalN/LPS was evaluated through the comet assay. Results: The elevated level of lipid peroxides induced by D-GalN/LPS was significantly (p50.05) reverted in lycopene pretreated animals. Lycopene administration restored (p50.05) the decreased activities of enzymatic and nonenzymatic antioxidant markers during D-GalN/LPS induction. The DNA strand breaks (72.3 mM) generated during D-GalN/LPS toxic injury was significantly reduced (35.5 mM) upon pretreatment with lycopene as observed by reduced tail movement in comet assay. Discussion and conclusion: There is no conclusive report about lycopene-assisted protection against free radical mediated toxic injury induced by D-GalN/LPS. Our findings reveal that lycopene effectively combated oxidative damage and protected antioxidant defense status of the cell. Pretreatment of lycopene also offers protection against the DNA damage and confirms the antioxidant nature of the phytonutreint against experimental hepatitis.

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Section: Discussionmentioning

confidence: 95%

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Abdulazeez

Devaki

2013

Pharmaceutical Biology

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“…30) Among the numerous models of experimental hepatitis, D-GalN induced liver damage is very similar to human viral hepatitis in its morphological and functional features. 31) Oxygen-derived free radicals released from activated hepatic macrophages are the primary cause of D-GalN-induced liver damage. 32) In this study, cichoric acid attenuated significantly D-GalN-induced hepatocyte injury after the cells were pretreated with test compound.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from <i>Cichorium intybus</i> Leaves in Cell Culture

Zhang

Dai

et al. 2014

Biological & Pharmaceutical Bulletin

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Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis B virus (HBV) and anti-human immunodeficiency virus effects. Cichoric acid is a caffeic acid derivative from Cichorium intybus. In the study, the anti-hepatitis B property of cichoric acid was evaluated by the D-galactosamine (D-GalN)-induced normal human HL-7702 hepatocyte injury model, the duck hepatitis B virus (DHBV)-infected duck fetal hepatocytes and the HBV-transfected cell line HepG2.2.15 cells, respectively. The results showed that cichoric acid attenuated significantly D-GalN-induced HL-7702 hepatocyte injury at 10-100 µg/mL and produced a maximum protection rate of 56.26%. Moreover, cichoric acid at 1-100 µg/mL inhibited markedly DHBV DNA replication in infected duck fetal hepatocytes. Also, cichoric acid at 10-100 µg/mL reduced significantly the hepatitis B surface and envelope antigen levels in HepG2.2.15 cells and produced the maximum inhibition rates of 79.94% and 76.41%, respectively. Meanwhile, test compound at 50-100 µg/mL inhibited markedly HBV DNA replication. In conclusion, this study verifies the antihepatitis B effect of cichoric acid from Cichorium intybus leaves. In addition, cichoric acid could be used to design the antiviral agents.

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“…Elevated serum enzymes are indicative of cellular leakage and loss of functional integrity of the cell membrane in liver (Amresh et al, 2007b;Drotman & Lawhorn, 1978). Hence, significant rise in the serum enzyme levels could be taken as an index of liver damage (Lim et al, 2000). Pretreatment with 50% ethanol extract of whole plant of Amaranthus spinosus attenuated the increased activities of these enzymes in serum caused by d-GalN/LPS recovery towards normalization, and suggests that A. spinosus extract causes parenchymal cell regeneration in liver, thus protecting membrane fragility, thereby, decreasing enzyme leakage.…”

Section: Discussionmentioning

confidence: 99%

Protective effect ofAmaranthus spinosusagainstd-galactosamine/lipopolysaccharide-induced hepatic failure

Hussain¹,

Gupta²,

Singh³

et al. 2010

Pharmaceutical Biology

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Effects of acetylbergenin against D -galactosamine-induced hepatotoxicity in rats

Cited by 59 publications

References 23 publications

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Effect of lycopene on oxidative stress induced duringd-galactosamine/lipopolysaccharide-sensitized liver injury in rats

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from <i>Cichorium intybus</i> Leaves in Cell Culture

Protective effect ofAmaranthus spinosusagainstd-galactosamine/lipopolysaccharide-induced hepatic failure

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