2003
DOI: 10.1016/s0890-6238(02)00078-3
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Effects of acrylamide on rodent reproductive performance

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Cited by 193 publications
(133 citation statements)
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“…Additionally, ACR has carcinogenic potential (Dearfield et al, 1988;IARC, 1994), and exerts adverse effects on male reproduction, including dominant lethality, degeneration of testicular epithelial tissue, and impaired fertilization (Sakamoto et al, 1988;Adler et al, 2000;Tyl and Friedman, 2003). It has been demonstrated that reproductive toxicity is not only induced by ACR, but also by glycidamide (GA), an oxidized metabolite of ACR generated by CYP2E1, which exerts clastogenic effects on spermatids (Adler et al, 2000;Costa Correspondence: Makoto Shibutani (E-mail: shibutan@nihs.go.jp) et al, 1992;Ghanayem et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, ACR has carcinogenic potential (Dearfield et al, 1988;IARC, 1994), and exerts adverse effects on male reproduction, including dominant lethality, degeneration of testicular epithelial tissue, and impaired fertilization (Sakamoto et al, 1988;Adler et al, 2000;Tyl and Friedman, 2003). It has been demonstrated that reproductive toxicity is not only induced by ACR, but also by glycidamide (GA), an oxidized metabolite of ACR generated by CYP2E1, which exerts clastogenic effects on spermatids (Adler et al, 2000;Costa Correspondence: Makoto Shibutani (E-mail: shibutan@nihs.go.jp) et al, 1992;Ghanayem et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The No Observed Adverse Effect Level (NOAEL) for reproductive toxicity was assessed to be 2-5 µg/kg/day in rats. This dose is at least four time higher than doses need acrylamide neurotoxicity and 2000 time more than estimated dietary exposures amount (33)(34)(35). Furthermore, administration of 0.5-10 mg/kg of AA retarded growth of rats and decrease epididymal sperm reserves compared with control group.…”
Section: Reproductive Toxicity Of Acrylamidementioning
confidence: 99%
“…In this case, acrylamide can degenerate epithelial cells of seminiferous tubules and harmfully affect the number and shape of sperm, probably because of its interfering effects on kinesin motor protein in the flagella of sperm (Jin et al 2013;Tyl and Friedman 2003;Tyl et al 2000;.…”
Section: Reproductive Toxicitymentioning
confidence: 99%