Effects of acute myocardial infarction and of noradrenaline infusion on fatty acid composition of serum lipids

Jurand, Jadwiga; Oliver, M.F.

doi:10.1016/0021-9150(70)90013-4

Cited by 23 publications

(12 citation statements)

References 31 publications

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“…The so-far existing research has been performed on primates [3] and rats [11]. In the study by Siscovick et al [3] RBC membrane levels of EPA + DHA (corresponding to our omega-3 index) were altered only slightly (0.33%) from the pre-mortem to the post-mortem state, suggesting a non-significant effect on these FA by the cardiac arrest itself.…”

Section: Discussionmentioning

confidence: 94%

“…In the study by Siscovick et al [3] RBC membrane levels of EPA + DHA (corresponding to our omega-3 index) were altered only slightly (0.33%) from the pre-mortem to the post-mortem state, suggesting a non-significant effect on these FA by the cardiac arrest itself. Jurand et al [11] injected rats with noradrenaline, but could not demonstrate any variation in serum FA. Our study confirms the findings in these animal studies, and is strengthened by similar results obtained in SCA-patients both with and without an AMI.…”

Section: Discussionmentioning

confidence: 99%

“…Stress-induced or injected adrenalin can activate phospholipases, releasing FA from cell membrane phospholipids leading to falsely low post-resuscitation measurements. The only evaluation of this question has so far been performed in animal studies, in which no significant effect of adrenalin on the FA composition in RBC [3] or serum lipids [11] has been observed. FA stability after an episode of cardiac arrest has previously not been reported in humans, and this was the primary aim of our study.…”

Section: Introductionmentioning

confidence: 99%

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Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Aarsetoey

Lindner

et al. 2011

Lipids

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In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) expressed as weight percentage of total FA) has recently been proposed as a new risk factor for death from coronary artery disease, especially following sudden cardiac arrest (SCA). As blood samples often haven been harvested after the event, the aim of our study was to evaluate the stability of RBC fatty acids following SCA. The total FA profile, including the omega-3 index, was measured three times during the first 48 h in 25 survivors of out-of-hospital cardiac arrest (OHCA), in 15 patients with a myocardial infarction (MI) without SCA and in 5 healthy subjects. We could not demonstrate significant changes in the FA measurements in any of the groups, this also applied to the omega-6/omega-3 ratio and the arachidonic acid (AA)/EPA ratio. Furthermore, we compared the omega-3 index in 14 OHCA-patients suffering their first MI with that of 185 first-time MI-patients without SCA; mean values being 4.59% and 6.48%, respectively (p = 0.002). In a multivariate logistic regression analysis, a 1% increase of the omega-3 index was associated with a 58% (95% CI: 0.25–0.76%) reduction in risk of ventricular fibrillation (VF). In conclusion, the omega-3 index remained stable after an event of SCA and predicted the risk of VF.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Aarsetoey

Lindner

et al. 2011

Lipids

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“…In order to enable a comparison to be made with the effects of noradrenaline the study was expanded to include observations on the same subjects before and after exercise, which might be expected to result in a 71 predominant increase of the latter hormone (Vendsalu, 1960). Comparative studies on the plasma concentrations of adrenaline and noradrenaline have so far been limited to infusion studies (Lepeschkin et al, 1960;Carlson and Oro, 1965;Jurand and Oliver, 1970).…”

Section: Introductionmentioning

confidence: 99%

Cardiac Responses to Thermal, Physical, and Emotional Stress

Taggart¹,

Parkinson²,

Carruthers³

1972

BMJ

100

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SummaryWe have studied the effect of a short period of exposure to the intense heat of a sauna bath on the electrocardiogram and plasma catecholamine, free fatty acid, and triglyceride concentrations in 17 subjects with apparently normal hearts and 18 persons with coronary heart disease. Similar observations were made on 11 of the 17 normal subjects and on 7 of the persons with coronary heart disease in response to exercise.Exposure to heat was associated with an increase in plasma adrenaline with no change in noradrenaline, free fatty acid, or triglyceride concentrations. Exercise was associated with the expected increase in both plasma noradrenaline and adrenaline concentrations. A heart rate up to 180 beats/min was observed in response to both heat and exercise. Apart from the ST-T changes inherent to sinus tachycardia, ST-T segment abnormalities were frequent in response to heat in both the subjects with normal and abnormal hearts, but little change occurred in the ST-T configuration when the subjects were exercised to produce comparable heart rates. Ectopic beats, sometimes numerous and multifocal, were observed in some subjects of both groups in response to heat, but not to exercise. It seems likely that the net unbalanced adrenaline component ofthe increased plasma catecholamine concentrations (which is also seen in certain emotional stress situations) is predominantly responsible for ischaemic-like manifestations of the electrocardiogram in susceptible subjects. The observations provide further validation for previously reported studies that it is the increased plasma noradrenaline in response to emotional stress that is associated with the release of free fatty acids and ultimate hypertriglyceridaemia, of probable importance in the aetiology of atheroma.

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“…In 16 healthy normal subjects 18-41 years of age, 19% of the FFA were polyunsaturated; in atherosclerotic patients with normal lipidaemia, 17% were polyunsaturated and in those with hyperlipidaemia 15% were polyunsaturated. After a myocardial infarction the oleic acid level of the FFA fraction in plasma was found to be increased (Jurand & Oliver, 1970); in addition, in the plasma lipid fraction a decrease in the percentage of linolenic acid was found by some workers (Bang, Mess Thaysen & Thygesen, 1968) or a decrease in the percentage of linoleic acid balanced by an increase in some saturated and mono-unsaturated fatty acids (Kirkeby, Myermann & Bjeikedal, 1968).…”

Section: Discussionmentioning

confidence: 99%

Effect of Fatty Acids on the Ventricular Arrhythmia Threshold in the Isolated Heart of the Rabbit

Murnaghan

1981

British J Pharmacology

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1 The ventricular arrhythmia threshold (VAT) was measured in the isolated Ringer-perfused rabbit heart (Langendorff preparation) by applying a single 10 ms square-wave pulse of current to the left ventricle during the vulnerable period of late systole under normoxic and hypoxic conditions. 2 The sodium salt of the fatty acid was bound to albumen and incorporated in the Krebs-Henseleit solution which was maintained at 37°C and gassed with 95 %02 and 5% CO2 (normoxia) or 5% CO2 in air (hypoxia). 3 Saturated fatty acids failed to alter the VAT under normoxia. 4 Naturally occurring long-chained saturated and mono-unsaturated fatty acids with chain lengths varying from 14 to 20 carbons, but not the 12 carbon lauric acid, potentiated the effect of the hypoxia in lowering the VAT.5 Short-chained 8 and 10 carbon saturated and long-chained polyunsaturated fatty acids antagonized the effect of hypoxia on the VAT.6 In addition the polyunsaturated acids antagonized the potentiating effect of the long-chained saturated and mono-unsaturated acids on the hypoxia in lowering the VAT.7 The fatty acids did not alter the duration or type of the induced arrhythmia.

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Effects of acute myocardial infarction and of noradrenaline infusion on fatty acid composition of serum lipids

Cited by 23 publications

References 31 publications

Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Cardiac Responses to Thermal, Physical, and Emotional Stress

Effect of Fatty Acids on the Ventricular Arrhythmia Threshold in the Isolated Heart of the Rabbit

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