Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres

Yu, Fang; Hedström, Margareta; Cristea, Alexander; Dalén, Nils; Larsson, Lars

doi:10.1111/j.1365-201x.2007.01699.x

Cited by 32 publications

(55 citation statements)

References 55 publications

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“…The lack of an eVect on type 2A Wbres might be explained by the observation that, whereas type 1 Wbres were consistently found to be slower Larsson et al 1997) in elderly subjects than in young subjects, type 2A Wbres were found to be slower in some population of elderly subjects (D'Antona et al , 2007Yu et al 2007), but not in other populations (D'Antona et al 2007;Larsson et al 1997).…”

Section: Unloaded Shortening Velocity Of Muscle Wbresmentioning

confidence: 72%

“…Although it is generally believed that speciWc force of muscle Wbres declines with age Larsson et al 1997;Yu et al 2007), contradictory results have been reported (Trappe et al 2003). Comparing populations of elderly subjects with diVerent training background, it has been suggested that such discrepancy could depend on variations in activity levels of the population of elderly subjects considered (D'Antona et al 2007).…”

Section: Size and Force Of Muscle Wbresmentioning

confidence: 96%

“…A large body of information has been reported on the eVect of ageing on structure and function of skeletal muscle Hook et al 2001;Larsson et al 1997;Reeves et al 2006;Trappe et al 2003;Young et al 1985;Yu et al 2007). It is well known that ageing determines a loss of muscle mass (Young et al 1985), followed by a disproportionate loss of strength and therefore by a decrease of speciWc force in vivo , and a slowing down of movements (Larsson et al 1979;Yu et al 2007).…”

Section: Introductionmentioning

confidence: 97%

“…In determining impairment of muscle speciWc force and velocity in vivo a signiWcant role can be played by changes in single muscle Wbre properties. It has been shown, in fact, that single muscle Wbres from elderly humans can have lower speciWc force and unloaded shortening velocity than Wbres from young controls Larsson et al 1997;Yu et al 2007).…”

Section: Introductionmentioning

confidence: 98%

“…It is well known that ageing determines a loss of muscle mass (Young et al 1985), followed by a disproportionate loss of strength and therefore by a decrease of speciWc force in vivo , and a slowing down of movements (Larsson et al 1979;Yu et al 2007). In determining impairment of muscle speciWc force and velocity in vivo a signiWcant role can be played by changes in single muscle Wbre properties.…”

Section: Introductionmentioning

confidence: 99%

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Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women

et al. 2008

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Four elderly women (78 +/- 4.3 years) were resistance trained (RT) for one year and needle biopsies of the vastus lateralis muscle were taken pre- and post-RT. A training intensity of 60% one-repetition maximum (1RM) was adopted for the entire duration of the study. Following RT, significant gain in isometric force of the quadriceps muscles was observed and MHC isoform distribution of vastus lateralis muscle showed a very significant shift from MHC-1 and MHC-2X towards MHC-2A, i.e. a bi-directional shift. A large population (n = 310) of individual skinned muscle fibres were dissected from biopsy samples and used for determination of cross-sectional area (CSA), specific force (Po/CSA) and unloaded shortening velocity (Vo) at 12 degrees C and maximum activation. Fibres were classified on the basis of their MHC isoform content determined by SDS-PAGE in three pure fibre types (1, 2A and 2X) and two hybrid fibre types (1-2A and 2AX). Whereas the CSA of individual muscle fibres did not change, Po/CSA was significantly higher in both type 1 and type 2A fibres post training. Vo of type 1 fibres was significantly higher post-training, whereas no change in Vo was observed in type 2A fibres. The number of pure type 2X fibres was very low especially post-training and did not enable a statistically significant comparison. The data suggest that in elderly women moderate and prolonged RT: (1) can determine similar adaptations in MHC distribution of skeletal muscle to those expected in young subjects; (2) can improve function of muscle fibres.

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Section: Unloaded Shortening Velocity Of Muscle Wbresmentioning

confidence: 72%

Section: Size and Force Of Muscle Wbresmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women

et al. 2008

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Differences in the mass and quality of the quadriceps with age and sex and their relationships with knee extension strength

Mizuno

Matsui

Tomida

et al. 2021

J cachexia sarcopenia muscle

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Background Although muscle quality evaluations are currently considered important for diagnosing sarcopenia, data from the general population are lacking. This study used mid‐thigh computed tomography measurements to evaluate age‐related and sex‐related differences in quadriceps femoris muscle quality and mass and their relationships with knee extension strength (KES). Methods Cross‐sectional data from 520 Japanese individuals (273 men and 247 women, mean age: 63.1 ± 10.6 years) were analysed. Mass and quality were assessed using quadriceps cross‐sectional areas (CSAs) and computed tomography values (CTVs), respectively. The four constituent muscles, intermuscular adipose tissue, and entire quadriceps area (total quadriceps muscles + intermuscular adipose tissue) were assessed, and the data were stratified by five age groups and sex. To evaluate age‐related decline, linear and quadratic equations were tested for fit according to the constituent muscles and sex. KES could be measured in 472 of the 520 participants (254 men and 218 women, mean age: 62.3 ± 10.3). Multiple linear regression analyses with age‐adjusted models were then used for evaluating the relationships between KES and quadriceps measurements. Results All muscle CSAs and CTVs showed downward trends with age (men: P < 0.001 for all; women: vastus medialis CTV, P = 0.004; others, P < 0.001); the intermuscular adipose tissue CSA did not show any trend (men: P = 0.938; women: P = 0.139), although its percentage of the entire quadriceps area showed an upward trend in both sexes (P < 0.001). Men exhibited a quadratic decline in the CSAs for the entire quadriceps area (P = 0.016), total quadriceps muscles (P = 0.021), the vastus medialis (P = 0.010) and vastus lateralis (P = 0.038), and all CTVs (rectus femoris, P = 0.044; others, P < 0.001). Women exhibited a quadratic equation in the CTV for rectus femoris (P = 0.031), but a linear decline in the other variables (P < 0.001 for all). Both the total quadriceps muscles CSA and CTV were significantly associated with KES in both sexes (P < 0.001). For each muscle, the CSAs of the vastus medialis (P < 0.001) and vastus intermedius (P = 0.001) were significantly associated with KES in men, whereas the vastus medialis CSA (P < 0.001), vastus lateralis CSA (P = 0.006), rectus femoris CSA (P = 0.020), and vastus intermedius CTV (P = 0.025) were significantly associated with KES in women Conclusions Age‐related quadriceps femoris changes in mass and quality differed by sex and the constituent muscles. The constituent muscles contributing to KES differed between men and women. Quadriceps CSA and CTV measurements are useful for objectively assessing age‐related and sex‐related muscle deterioration and KES.

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Sarcolemmal excitability changes in normal human aging

Lee

Boland-Freitas

2018

Muscle and Nerve

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Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres

Cited by 32 publications

References 55 publications

Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women

Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women

Differences in the mass and quality of the quadriceps with age and sex and their relationships with knee extension strength

Sarcolemmal excitability changes in normal human aging

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