Effects of aging and weaning on mRNA expression of leptin and CCK receptors in the calf rumen and abomasum

Yonekura, Shinichi; Kitade, K.; Furukawa, Gen; Takahashi, Kazuma; Katsumata, Noriyuki; Katoh, K.; Obara, Yoshiaki

doi:10.1016/s0739-7240(01)00114-x

Cited by 33 publications

(24 citation statements)

References 25 publications

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“…The distribution of mucosal and neuronal CCK receptors within the ovine duodenum has not been studied in detail. It can be assumed that the inhibitory action of CCK on the peripyloric region can be mediated by exhibiting a higher density of CCK-1 (CCK-A) rather than CCK-2 (CCK-B/gastrin) receptor subtypes (Yonekura et al, 2002). However, the role of CCK-1 receptor subtype in evoking motor response to CCK seems to be even greater than the role of CCK-2 receptor subtype (Dockray, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…It is also believed that CCK plays a major role in gastrointestinal peristalsis (Dockray, 1994;. Several extensive studies have been performed in order to explain its precise role in the gastrointestinal motility (Yonekura et al, 2002;Adelson et al, 2004;Varga et al, 2004) as the whole problem is not easy to assess. These difficulties are due to the existence of multiple molecular forms of CCK, possible hormonal or neural effects and interactions, the different effects in various segments of the gastrointestinal tract, biphasic responses, unresolved problems with the localization of CCK receptor subtypes and CCK release, the complexity of gastrointestinal motor functions, and species differences Li et al, 1999;Wang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Cholecystokinin-dependent selective inhibitory effect on ‘minute rhythm’ in the ovine small intestine

Romanski

2009

Animal

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Cholecystokinin (CCK) can exert multiple actions on intestinal motility but its effect on the small-intestinal 'minute rhythm' (MR) is virtually unknown. Therefore, the electrical activity from the abomasal antrum, duodenal bulb, duodenum, jejunum and ileum was continuously recorded in six sheep before, during and after slow intravenous administration, of three doses each, of cholecystokinin-octapeptide (CCK-OP) and cerulein. In four of these sheep, two additional electrodes and the strain gauge force transducer were also inserted in the duodenum. Chronic experiments were performed in the fasted and non-fasted animals and saline or CCK peptides were injected during phases 1, 2a or 2b of the duodenal migrating myoelectric complex (MMC). The administration of both CCK peptides in various doses evoked an inhibitory effect mostly in the duodenal bulb, except for the lowest dose of cerulein. The effects of 20 times greater doses of CCK-OP than that of cerulein were more pronounced. The introduction of both CCK peptides during phase 1 of the MMC produced no marked or significant response. In non-fasted animals, the effects of both hormonal peptides, given during phase 2b of the MMC, were often stronger than those given during phase 2a, while in fasted animals the effects of CCK peptides, administered in the course of phases 2a and 2b of the MMC, were similar. Both higher doses of CCK peptides increased the number of spike bursts within the given MR pattern in the duodenum and decreased the incidence of MR mostly in the duodenal bulb. The inhibitory effects of both CCK peptides on the bulbar MR exhibited a dose-response character, though the lowest dose often evoked the slight stimulatory response. It is concluded that CCK principally exerts an inhibitory effect upon the MR in the duodenal bulb and modifies the MR in the duodenum by increasing the spike burst number in a given MR pattern. Both these actions of CCK peptides seem to be physiological. There is a positive relationship between the intensity of the refractory period and the demonstrated effect of CCK in the duodenum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cholecystokinin-dependent selective inhibitory effect on ‘minute rhythm’ in the ovine small intestine

Romanski

2009

Animal

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“…CCK 1 (CCK-A) and CCK 2 (CCK-B/gastrin) receptors and the heterogeneity of CCK 1 receptor subtype was suggested (Miyasaka and Funakoshi 2003;Morton et al 2002). CCK receptors are also present in ruminants (K ania et al 2002;Le Drean et al 1999;Onaga et al 1997;Yonekura et al 2002). These receptors are localized either on the smooth muscle cells or within central and peripheral nervous system structures controlling gastrointestinal motility.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski¹

2007

Acta Vet. Brno

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Cholecystokinin (CCK) can affect phasic contractions and the minute rhythm (MR) in ovine duodenum but its effect on the tonic component remains unclear. Thus, the aim of this study was to assess whether the hormone exerts significant changes on phasic and tonic components of the duodenal motor activity and on phasic and tonic components of the duodenal MR. Mechanical and electrical activities of the duodenum were recorded in four sheep before and after slow intravenous cholecystokinin octapeptide (CCK-OP, doses 20, 200 and 2000 ng/kg b.w.) and cerulein (doses 1, 10 and 100 ng/kg b.w.) administration in the course of phase 2b of the migrating motor complex. During 5-20-minute periods the area under contraction curve for phasic, tonic and total motor activity was measured for the whole curve and separately for the MR-related activity. It was found that both CCK peptides stimulate phasic and tonic components of the duodenal motor activity as well as both these components of the duodenal MR. The effect of CCK peptides on the tonic component was stronger than on the phasic component. These effects were similar in non-fasted and fasted animals. CCK-OP evoked slightly greater effect than cerulein. The effects of these CCK peptides on phasic and tonic components of the MR were similar. It is concluded that CCK-OP and cerulein stimulate both phasic and tonic components of the duodenal motor activity and phasic and tonic components related to the MR in sheep. , small bowel, myoelectrical and motor activity, cholecystokinin Ruminants

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“…In calves receiving milk replacer based on skimmed milk powder, plasma concentrations of gastrin decreased from 1 to 3 weeks of age, but this is reversed for CCK (Guilloteau et al 1992a(Guilloteau et al ,b, 1997; after weaning, the basal and stimulated plasma concentrations of these two peptides increased (Toullec et al 1992). Moreover, it is suggested that CCK may modulate gastric leptin expression and secretion in pre-weaning milk-fed calves (Yonekura et al 2002) as well as in rats (Brzozowski et al 1999). Inversely, duodenal leptin stimulates CCK secretion and there is evidence for a positive leptin -CCK feedback loop (Guilmeau et al 2003).…”

Section: Factors Regulating Gastrin and Cholecystokinin Releasementioning

confidence: 99%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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Effects of aging and weaning on mRNA expression of leptin and CCK receptors in the calf rumen and abomasum

Cited by 33 publications

References 25 publications

Cholecystokinin-dependent selective inhibitory effect on ‘minute rhythm’ in the ovine small intestine

Cholecystokinin-dependent selective inhibitory effect on ‘minute rhythm’ in the ovine small intestine

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

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