Effects of amylose content on starch-chitosan composite film and its application as a wound dressing

Wu, Wen-Ching; Hsiao, Po-Yuan; Huang, Yi‐Cheng

doi:10.1007/s10965-019-1770-0

Cited by 26 publications

(13 citation statements)

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“…The enzyme-linked immunosorbent assay indicated that glutinous rice starch–CS film was more capable of alleviating inflammation than other films. Briefly, the results indicated the suitability of the glutinous rice starch–CS film with for wound dressing material [55] .…”

Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

224

115

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Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The main problem in wound management is that the majority of wounds are colonized with microbes, whereas this does not mean that all wounds will be infected. In this review, we address the problems that clinicians face to manage while treat acute and chronic wounds. Moreover, we demonstrate the pathophysiology, etiology, prognosis and microbiology of wounds. We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment. In addition, authors review researches which included the use of gels and dermal films as wound healing agents. It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards. However, are the current strategies as desirable as medical society wish?

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Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

224

115

View full text Add to dashboard Cite

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“…1–4 The potential of biodegradable polymers from agro-resources such as the polysaccharides (e.g., starch) has long been recognized. 5–9…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

et al. 2021

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(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of −38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10−13) g.Pa−1.s−1.m−1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.

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“…Amilosa berbentuk heliks dengan molekulnya terikat oleh α-(1,4)-D-glukosa, dengan berat molekul rataratanya adalah 105 Da. Sebaliknya amilopektin adalah kelompok polimer bercabang yang tiap unitnya dihubungkan secara linier oleh ikatan α-(1,4) pada rantai lurusnya, serta ikatan α-(1,6) pada titik percabangan 3 . Pati termasuk kedalam polimer alam, karena pati dihasilkan dari pemanfaatan karbon dioksida dan air melalui proses fotosintesis, serta dapat terdegradasi dengan sempurna 4 .…”

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“…Gambar 1 Struktur kimia (a) amilosa (b) amilopektin dan (c) heliks amilosa Pati mulai banyak digunakan sebagai salah satu zat tambahan dalam sediaan farmasi karena pati memiliki sifat polimer hidrofilik yang dapat dengan mudah diubah menjadi berbagai bentuk karena tidak beracun, bersifat biodegradabel, inert, biokompatibilitas, mudah ditemukan dan harganya relatif murah 3,5 . Maka dari itu pati sering sekali digunakan dalam sediaan farmasi karena pati dapat berfungsi sebagai pembawa obat yang dapat meningkatkan kelarutan obat, meningkatkan biokompatibilitas, mengurangi efek samping dari molekul obat, dan stabilitas penyimpanannya 6 .…”

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Review Komposit Pati–Kitosan: Perannya dalam Berbagai Sistem Penghantaran Obat

2022

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AbstrakPati adalah polisakarida yang berasal dari alam yang banyak terdapat secara luas dalam biji, buah, akar, dan batang. Pati sering digunakan sebagai salah satu zat tambahan dalam sediaan farmasi karena pati memiliki sifat polimer hidrofilik yang dapat dengan mudah diubah menjadi berbagai bentuk karena tidak beracun, bersifat biodegradable, inert, biokompatibilitas, mudah ditemukan dan harganya yang relatif murah. Dalam dunia farmasi untuk mengoptimalkan fungsi dari pati biasanya pati sering digabungkan dengan kitosan sebagai komposit, karena penggabungan tersebut dapat meningkatkan kelarutan, mengurangi toksisitas dalam tubuh, meningkatkan aktivitas farmakologi, meningkatkan stabilitas, meningkatkan biodegradabilitas dan memberikan sifat unggul pada sediaan tersebut. Penulisan review artikel ini bertujuan untuk mengumpulkan informasi tentang penggunaan komposit pati-kitosan sebagai eksipien dalam berbagai sistem penghantaran obat. Penulisan karya tulis ilmiah ini menggunakan review pustaka. Penelusuran pustaka dilakukan menggunakan database Google, Google Schoolar, Science Direct, Pubmed dan MDPI. Sumber pustaka yang digunakan yaitu 10 tahun terakhir dengan rentang tahun 2011-2021 dengan kriteria inkulsi yaitu komposit pati kitosan yang memiliki peran dalam sistem penghantaran obat; kriteria eksklusi yaitu pati dan kitosan yang tidak relevan. Berdasarkan review artikel yang dilakukan didapatkan hasil dari pati dan kitosan yang dapat digunakan untuk sistem penghantaran obat dalam berbagai sediaan seperti film, nanopartikel, tablet dan juga gel. adanya peningkatan manfaat pada komposit pati kitosan dalam sediaan film, nanopartikel, tablet dan juga gel. Komposit ini dapat memberikan material baru yang lebih optimal dibandingkan dengan penggunaan tunggal.

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Effects of amylose content on starch-chitosan composite film and its application as a wound dressing

Cited by 26 publications

References 75 publications

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

Review Komposit Pati–Kitosan: Perannya dalam Berbagai Sistem Penghantaran Obat

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