Effects of an Anti-androgen, SH 714 (6-Chlor Δ6-l, 2α- Methylen-17α-hydroxyprogesterone Acetate, Cyproterone Acetate) on Canine Prostatic Hyperplasia1

Neri, R.; Casmer, Charles; Zeman, William V.; Fielder, Frank; Tabachnick, I. I. A.

doi:10.1210/endo-82-2-311

Cited by 32 publications

(13 citation statements)

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“…The loss of secretory function was con firmed by failure of histochemical demonstra tion of epithelial acid phosphatase, aminopeptidase and zinc. Similar findings were observed in intact dogs with spontaneous prostatic hy perplasia after treatment with CA and nonste roidal antiandrogens as well as after castration (8,18,20,30,31). CA abolishes the epithelial 3a-diol effect.…”

Section: Discussionsupporting

confidence: 75%

Effects of Cyproterone Acetate on Experimentally Induced Canine Prostatic Hyperplasia

Tunn¹,

Senge²,

Schenck³

et al. 1980

Urol Int

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The effect of 3α-androstanediol (3α-diol), 17β-estradiol (E₂) and cyproterone acetate (CA) on prostates in castrated beagle dogs were investigated by histologjcal and histochemical examinations. A significant increase of prostatic weight occurred after 6 months’ treatment with 3α-diol alone and in combination with E₂. Histologically and histochemically, two different types of prostatic enlargement were observed: first, administration of 3α-diol resulted in diffuse glandular hyperplasia with replacement of functional activity monitored by strongly positive reactions for acid phosphatase, aminopeptidase and zinc. Second, 3α-diol plus E₂ produced stratified squamous metaplasia with cystic lumina and loss of the typical morphological structure. These glands showed negative reactions for acid phosphatase, aminopeptidase and zinc. In both types of prostatic hyperplasia CA abolished epithelial or metaplastic proliferation and induced atrophy of glandular epithelium. In estrogenized dogs activation of the fibromuscular stroma was obvious. CA prevented prostatic hyperplasia by atrophying epithelial effects.

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Section: Discussionsupporting

confidence: 75%

Effects of Cyproterone Acetate on Experimentally Induced Canine Prostatic Hyperplasia

Tunn¹,

Senge²,

Schenck³

et al. 1980

Urol Int

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“…These biochemical events are apparently conditioned by glandular atrophy as shown histologically. Simi¬ lar microscopic findings were observed in intact dogs with spontaneous BPH after treatment with CA (Neri et al 1968) and non-steroidal antiandrogens (Neri 8c Monahan 1972) as well as after castration (Huggins 1945;Neri et al 1968). Atrophy of glandular epithelium was called a histological marker of gonadectomy in canine prostate (Leav et al 1971), and the CA effect is like this.…”

Section: Zinc Contentmentioning

confidence: 88%

Biochemical and Histological Studies on Prostates in Castrated Dogs After Treatment With Androstanediol, Oestradiol and Cyproterone Acetate

Tunn

Senge

Schenck

et al. 1979

Acta Endocrinologica

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The effect of cyproterone acetate (CA) on experimentally induced benign prostatic hyperplasia (BPH) in the castrated dog was investigated. BPH was induced by 6 months' treatment with 3\g=a\-androstanediol (3\g=a\-diol) alone and in combination with 17\g=b\-oestradiol(Oe2). RNA, DNA and zinc content of the glands were determined in addition to histological examination and measurement of the prostates. Two different types of prostatic enlargement were observed. First, 3\g=a\-diolinduced typical diffuse canine hyperplasia with replacement of functional activity. DNA, RNA and the zinc content of total glands were increased compared with intact controls.

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“…Über die Auswir kungen der Kastration auf die Prostata des Hundes lie gen neben verschiedenen lichtmikroskopischen und histochemischcn Ergebnissen [Huggins und Clark, 1940;Neri et al, 1961;Gouvelis et al, 1971] auch solche eini ger ultrastrukturelier Untersuchungen vor. Ultrastrukturclle Veränderungen an der Prostata wurden bisher erst für Hunde, bei denen die Kastration schon relativ lange-30Tage [Leav e t al., 1971], 120Tage [Hohbach, 1977] -zurücklag, beschrieben.…”

Section: Introductionunclassified

“…Lichtmikroskopische Untersuchungen der Pro stata des Hundes nach Orchiektomie [Huggins und Clark. 1940;Neri et al, 1961;Ofner et al, 1974] die ausser einer Abnahme der Zellhöhe und der Zahl der Sekretgranula noch die typischen Charakteristika des Prostataepithels zeigen, kommen in grösserer Zahl andere vor, die schwerwiegende morphologische Verän derungen erkennen lassen. Dabei ist das Auftreten von grossen Fettvakuolen, die einen erheblichen Teil des Zytoplasmas einnehmen können, besonders auffallend.…”

Section: Introductionunclassified

Frühe Veränderungen an der Prostata des Hundes nach Kastration

Sinowatz¹

1984

Cells Tissues Organs

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Using electron microscopic techniques the prostate glands of male Beagle dogs were studied 3 days after castration. At this time marked differences in the extent of alterations of the glandular epithelium were observed: Whereas several acini showed only minor changes with reduction of epithelial height and diminution of secretory granules, many acini were severely affected with pronounced alteration of cellular structure and accumulation of large lipid droplets. A constant feature was the stimulation of the basal cells of the grandular epithelium. Additionally, in some areas of the gland aggregations of stimulated basal cells forming an acinus-like structure with a slit-like lumen were found. Our study shows that castration leads to marked alterations of prostatic epithelium within a short time. Androgen deprivation causes regressive changes of secretory epithelial cells, but clearly stimulates the basal cell population.

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Effects of an Anti-androgen, SH 714 (6-Chlor Δ⁶-l, 2α- Methylen-17α-hydroxyprogesterone Acetate, Cyproterone Acetate) on Canine Prostatic Hyperplasia¹

Cited by 32 publications

References 0 publications

Effects of Cyproterone Acetate on Experimentally Induced Canine Prostatic Hyperplasia

Effects of Cyproterone Acetate on Experimentally Induced Canine Prostatic Hyperplasia

Biochemical and Histological Studies on Prostates in Castrated Dogs After Treatment With Androstanediol, Oestradiol and Cyproterone Acetate

Frühe Veränderungen an der Prostata des Hundes nach Kastration

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