Introduction and Objectives: Diabetes Mellitus is complex metabolic disorder and have appeared as gigantic public health problem worldwide. The prevalence of specifically type 2 diabetes mellitus is increasing in adult population due to sedentary lifestyle and more junk food consumption leading to obesity. This further is linked with decreased insulin sensitivity of the tissues and insulin resistance which is major indicator of type 2 diabetes mellitus. Lifestyle modifications are considered as one of the important cornerstone in management of diabetes mellitus. Therefore present study has been undertaken to assess, in a randomized manner, the impact of life style modification in form of structured exercise therapy on anthropometric and biochemical parameters in young adults newly diagnosed with type 2 diabetes mellitus. Materials and Methods: Total of 148 patients of age group 20-45 years with newly diagnosed T2DM were enrolled in the study as per eligibility criteria. The patients were divided randomly into two groups as Diabetic controls and interventional group. Socio-demographic, Anthropometric and Biochemical parameters were evaluated at baseline and at the end of six months for the study groups. Whereas the impact of lifestyle modification is studied at different time intervals, .i.e at baseline and at the end of 2nd, 4th and 6th months were studied. P value < 0.05 was considered statistically significant. IBM SPSS version 22 was used for statistical analysis. Results: There was significant improvement found in majority of anthropometric and biochemical parameters in intervention group at the end of six months of structured exercise therapy.