Effects of antimony on rats following 90-day exposure via drinking water

Poon, Raymond; Chu, Ih; Lecavalier, Pierre; Valli, V. E.; Foster, Warren G.; Gupta, Shalini; Thomas, Barb R.

doi:10.1016/s0278-6915(97)80120-2

Cited by 91 publications

(52 citation statements)

References 19 publications

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“…22,51 The accumulation in RBCs was also observed when Te or arsenic was ingested. As mentioned above, the accumulated species of Te and arsenic were the dimethylated forms.…”

Section: ·2 Metabolism Of Antimony Based On the Characterizationmentioning

confidence: 99%

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Ogra

2009

ANAL. SCI.

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Tellurium and antimony are widely used in industry because of their unique chemical and physical properties. Although these metalloids, which belong to period 5 of the periodic table of elements, are known to be non-essential and harmful, or the so-called "exotic" elements, little is known about their toxic effects and metabolism. The present review describes the role of speciation in considering the metabolism of tellurium and antimony from the viewpoint of toxicometallomics. Inorganic tellurium in the form of tellurite is reduced and simply methylated in the body. Rat red blood cells accumulate tellurium in the form of dimethylated tellurium, and tellurium is excreted into urine as trimethyltelluronium. Although selenium, which belongs to the same group as tellurium, is known to be excreted in the form of selenosugar as the major urinary metabolite, tellurosugar was not detected by an inductively coupled plasma-mass spectrometer hyphenated with an HPLC. Speciation studies revealed that the major metabolic pathway of antimony is oxidation in human and rat, and methylation also occurs as a minor metabolic pathway in humans.

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“…22,51 The accumulation in RBCs was also observed when Te or arsenic was ingested. As mentioned above, the accumulated species of Te and arsenic were the dimethylated forms.…”

Section: ·2 Metabolism Of Antimony Based On the Characterizationmentioning

confidence: 99%

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Ogra

2009

ANAL. SCI.

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“…Its other properties, such as solubility and adsorption behaviour, are similar to those of arsenic (Gebel, 1997;Filella, Belzile & Chen, 2002a). Organic antimony compounds are the less toxic forms and between the inorganic forms, Sb (III) is 10-fold more toxic than Sb (V) (Poon et al, 1998;Rivas, López-García & Hernández-Córdoba, 2009;Seiler, Sigel & Sigel, 1988). Therefore, Sb is considered a priority pollutant by the United States Environmental Protection Agency (USEPA) (USEPA, 2009) and the European Union (EU).…”

Section: Introductionmentioning

confidence: 99%

Migration of antimony from polyethylene terephthalate used in mineral water bottles

et al. 2015

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The influence of storage time and temperature on Sb migration from PET bottles into mineral water was studied in short-term tests lasting up to 15 days and long-term studies lasting up to 220 days. Samples purchased were stored in three different coloured bottles: clear (CL), light blue (LB) and dark blue (DB). Sb migration was assayed by HG-AFS for total determination and HPLC-ICP-MS for speciation analysis. Migration studies showed that waters stored at 4 and 20ºC were not subject to Sb migration. At 40ºC there was a significant increase in Sb concentration, although the maximum limit established by the European Union (5.0 µg L -1 ) was not exceeded, whereas at 60ºC samples were subject to considerable Sb migration after 30 days of storage. In this case, the maximum limit established by the European Union was exceeded and both Sb (V) and Sb (III) were detected.

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“…In addition, the incidence of lung cancer has increased in industry workers exposed to Sb (McCallum, 2005). It is reported that Sb accumulated in RBCs of rats administered antimonite, although the chemical form of accumulated Sb is still unclear (Poon et al, 1998). It is also reported that antimonate and trimethylantimony chloride were detected in urine of workers exposed to Sb (Krachler and Emons, 2001).…”

Section: Introductionmentioning

confidence: 99%

Metabolism of tellurium, antimony and germanium simultaneously administered to rats

Kobayashi

Ogra

2009

J. Toxicol. Sci.

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-Recently, tellurium (Te), antimony (Sb) and germanium (Ge) have been used as an alloy in phase-change optical magnetic disks, such as digital versatile disk-random access memory (DVD-RAM) and DVD-recordable disk (DVD-RW). Although these metalloids, the so-called "exotic" elements, are known to be non-essential and harmful, little is known about their toxic effects and metabolism. Metalloid compounds, tellurite, antimonite and germanium dioxide, were simultaneously administered to rats. red blood cells (RBCs): Te accumulated in RBCs in the dimethylated form, while Sb accumulated in the inorganic/non-methylated form. In addition, trimethyltelluronium (TMTe) was the urinary metabolite of Te, whereas Sb in urine was not methylated but oxidized. Ge was also not methylated in rats. These results suggest that each metalloid is metabolized via a unique pathway.

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Effects of antimony on rats following 90-day exposure via drinking water

Cited by 91 publications

References 19 publications

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Migration of antimony from polyethylene terephthalate used in mineral water bottles

Metabolism of tellurium, antimony and germanium simultaneously administered to rats

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