Effects of arginine vasopressin on firing activity and thermosensitivity of rat PO/AH area neurons

Yu, Tang; Yang, Yong‐Lu; Wang, N.; Shen, Ziling; Zhang, J.; Hu, Haiyan

doi:10.1016/j.neuroscience.2012.05.063

Cited by 20 publications

(15 citation statements)

References 32 publications

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“…The tonic negative regulation of body temperature by AVP might be due to the alteration of temperature‐sensitive neuron excitability in the preoptic area (POA). In our previous study (Tang et al ., ), we demonstrated that AVP excited warm‐sensitive neurons and suppressed cold‐sensitive neurons, while the percentages of AVP‐excited and AVP‐inhibited temperature‐insensitive neurons were nearly equivalent. Moreover, V1a receptor antagonists can decrease or reverse these effects, which is consistent with extracellular recording results (Moravec & Pierau, ).…”

Section: Introductionmentioning

confidence: 61%

“…AVP suppressed the inhibitory synaptic transmission to warm‐sensitive neurons, which supports the previous findings of warm‐sensitive neuron excitation by AVP (Moravec & Pierau, ; Tang et al ., ). However, the disinhibitory effect of AVP on IPSCs in cold‐sensitive neuron was inconsistent with the AVP inhibition of cold‐sensitive neuronal activity.…”

Section: Discussionmentioning

confidence: 97%

“…According to previously described procedures (Dean & Boulant, ; Tang et al ., ), horizontal hypothalamic slices were prepared from male Sprague–Dawley rats. Briefly, each rat was anaesthetized with sodium pentobarbital (100 mg/kg) and quickly decapitated.…”

Section: Methodsmentioning

confidence: 99%

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Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Sun

et al. 2018

Eur J of Neuroscience

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The preoptic area (POA) of the hypothalamus, containing temperature-sensitive and temperature-insensitive neurons, plays a key role in specific thermoregulatory responses. Although arginine vasopressin (AVP) has been shown to induce hypothermia by increasing the firing activities of warm-sensitive neurons and decreasing those of cold-sensitive and temperature-insensitive neurons, the effects of AVP on POA GABAergic transmission remain unknown. Herein, inhibitory postsynaptic currents (IPSCs) of temperature-sensitive and temperature-insensitive neurons in POA slices were recorded using whole-cell patch clamp. By monitoring changes in GABAergic transmission during AVP treatment, we showed that AVP decreased the amplitudes and frequencies of spontaneous IPSCs in mostly warm-sensitive neurons and in some temperature-insensitive neurons but increased these parameters in other temperature-insensitive neurons. The IPSC amplitude was reduced for only cold-sensitive neurons. RT-PCR and Western blot analyses further confirmed the POA expression of V1a receptors and GABA receptors, including the subunits α1, α2, α3, β2, β3 and γ2. The effects of AVP on IPSCs in temperature-sensitive and temperature-insensitive neurons were dependent on G proteins and intracellular Ca . AVP-mediated modulation was associated with changes in the kinetic parameters (decay time, 10-90% rise time, half-width). Together, these results suggest that AVP, acting via V1a receptors but not V1b receptors, differentially modulates GABAergic synaptic transmission and fine-tunes the firing activities of temperature-sensitive and temperature-insensitive neurons in the rat POA.

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Section: Introductionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 97%

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Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Sun

et al. 2018

Eur J of Neuroscience

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“…Let us briefly mention two important recent contributions on the mechanisms involved in this integrated homeostatic control (71,72). …”

Section: Evolutionary Aspects Of Brain/kidney Interactionsmentioning

confidence: 99%

“…Actually, ADH enhances thermo-sensitivity of warm-sensitive neurons and decreases thermo-sensitivity of cold-sensitive neurons. Such ADH modulatory actions promote heat loss and are probably involved in the ADH-induced hypothermia (71). …”

Section: Evolutionary Aspects Of Brain/kidney Interactionsmentioning

confidence: 99%

Homeostasis and the concept of 'interstitial fluids hierarchy': Relevance of cerebrospinal fluid sodium concentrations and brain temperature control (Review)

Agnati

Marcoli

Leo

et al. 2017

International Journal of Molecular Medicine

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In this review, the aspects and further developments of the concept of homeostasis are discussed also in the perspective of their possible impact in the clinical practice, particularly as far as psychic homeostasis is concerned. A brief historical survey and comments on the concept of homeostasis and allostasis are presented to introduce our proposal that is based on the classical assumption of the interstitial fluid (ISF) as the internal medium for multicellular organisms. However, the new concept of a hierarchic role of ISF of the various organs is introduced. Additionally, it is suggested that particularly for some chemico-physical parameters, oscillatory rhythms within their proper set-ranges should be considered a fundamental component of homeostasis. Against this background, we propose that the brain ISF has the highest hierarchic role in human beings, providing the optimal environment, not simply for brain cell survival, but also for brain complex functions and the oscillatory rhythms of some parameters, such as cerebrospinal fluid sodium and brain ISF pressure waves, which may play a crucial role in brain physio-pathological states. Thus, according to this proposal, the brain ISF represents the real internal medium since the maintenance of its dynamic intra-set-range homeostasis is the main factor for a free and independent life of higher vertebrates. Furthermore, the evolutionary links between brain and kidney and their synergistic role in H2O/Na balance and brain temperature control are discussed. Finally, it is surmised that these two interrelated parameters have deep effects on the Central Nervous System (CNS) higher integrative actions such those linked to psychic homeostasis.

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Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats

Wang

Bai

et al. 2014

Acta Histochemica

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Effects of arginine vasopressin on firing activity and thermosensitivity of rat PO/AH area neurons

Cited by 20 publications

References 32 publications

Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Homeostasis and the concept of 'interstitial fluids hierarchy': Relevance of cerebrospinal fluid sodium concentrations and brain temperature control (Review)

Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats

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