Effects of Atropine on Anterior Chamber Depth and Anterior Chamber Inflammation After Primary Trabeculectomy

Orengo-Nania, Silvia; El-Harazi, Shérif M.; Oram, Osman; Feldman, Robert M.; Chuang, Alice Z.; Gross, Ronald L.

doi:10.1097/00061198-200008000-00004

Cited by 14 publications

(8 citation statements)

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“…This is likely because cycloplegic eyedrops, including atropine, cause the crystalline lens to move posteriorly as the ciliary muscle relaxes. Similar deepening effects on the anterior chamber have been reported following the instillation of cyclopentolate in children 30 and atropine eyedrops for controlling post‐trabeculectomy ocular inflammation in adults 31 …”

Section: Discussionsupporting

confidence: 66%

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Low‐concentration atropine eyedrops for myopia control in a multi‐racial cohort of Australian children: A randomised clinical trial

Lee

Lingham

Błaszkowska

et al. 2022

Clinical Exper Ophthalmology

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Background: To test the hypothesis that 0.01% atropine eyedrops are a safe and effective myopia-control approach in Australian children.Methods: Children (6-16 years; 49% Europeans, 18% East Asian, 22% South Asian, and 12% other/mixed ancestry) with documented myopia progression were enrolled into this single-centre randomised, parallel, double-masked, placebo-controlled trial and randomised to receive 0.01% atropine (n = 104) or placebo (n = 49) eyedrops (2:1 ratio) instilled nightly over 24 months (mean index age = 12.2 ± 2.5 and 11.2 ± 2.8 years, respectively). Outcome measures were the changes in spherical equivalent (SE) and axial length (AL) from baseline.Samantha Sze-Yee Lee and Gareth Lingham contributed equally to this study.

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Section: Discussionsupporting

confidence: 66%

“…Similar deepening effects on the anterior chamber have been reported following the instillation of cyclopentolate in children 30 and atropine eyedrops for controlling post‐trabeculectomy ocular inflammation in adults. 31 …”

Section: Discussionmentioning

confidence: 99%

Low‐concentration atropine eyedrops for myopia control in a multi‐racial cohort of Australian children: A randomised clinical trial

Lee

Lingham

Błaszkowska

et al. 2022

Clinical Exper Ophthalmology

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“…Topical atropine is prescribed post‐operatively by some ophthalmologists to prevent shallowing or flattening of the anterior chamber and to reduce anterior chamber inflammation by stabilising the blood‐aqueous barrier . Orengo‐Nania and colleagues reported a small (approximately 0.1 mm) but statistically significant deepening of the anterior chamber in patients who used atropine. Atropine prevents shallowing of the anterior chamber by relaxation of the circular ciliary muscle that results in tightening of the lens zonules and posterior displacement of lens‐iris diaphragm…”

Section: The Effect Of Post‐operative Procedures/medicationsmentioning

confidence: 98%

Post‐trabeculectomy ocular biometric changes

Pakravan

Alvani

Esfandiari

et al. 2017

Clinical and Experimental Optometry

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Trabeculectomy is the most common surgical procedure for the management of glaucoma, which may significantly influence ocular biometry. Axial length and anterior chamber depth tend to decrease, while crystalline lens and choroidal thickness increase post-operatively. An increase in with-the-rule astigmatism is also observed after the procedure. Such biometric changes affect intraocular lens power calculation even years after the procedure. Non-contact biometric methods and postponing cataract surgery after trabeculectomy could reduce calculation errors associated with surgically induced alterations in ocular biometrics.

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“…Based on studies performed so far after topical instillation of atropine eye drops, there is an increase in the depth of the anterior chamber due to cycloplegia and relaxation of the radial muscle. [24][25][26][27]…”

Section: Discussionmentioning

confidence: 99%

The effect of atropine used in dobutamine stress echocardiography on pupil diameter

Soulis

Papaioannou

Zozolou

et al. 2022

European Journal of Ophthalmology

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Background The use of atropine during dobutamine stress echocardiography (DSE) is contraindicated in persons with narrow angle glaucoma though there is limited evidence that low doses of intravenous atropine do not cause pupillary dilation. Objective The aim of this study is to investigate whether atropine when administered in persons without glaucoma during dobutamine stress echocardiography causes pupillary dilation. Methods and Results Out of 144 patients without a history of glaucoma referred for DSE for clinical indications, 105 patients received intravenous atropine doses ranging from 0.1 mg to 1.25 mg (most patients received 0.25–0.75 mg). Pupil diameter of both eyes was measured under the same light conditions before and after the DSE using a CP-30 Optical Digital PD Ruler. For the total of 210 examined eyes pupil diameter remained unaltered after each DSE test (3.65 ± 0.799 mm before vs 3.63 ± 0.766 mm after, p = .737). Similarly, pupil diameter remained unchanged when left and right eyes were assessed separately (right eye: 3.770 ± 0.812 before vs 3.752 ± 0.745 mm after, p = .821 and left eye: 3.521 ± 0.770 before vs 3.499 ± 0.770 mm after, p = .806). Diameter of right and left pupil were also unaltered after grouping patients by sex and iris pigmentation. Age, weight, atropine dose and propranolol dose were not correlated with changes in pupil diameter. Conclusion Intravenous atropine in usual doses administered in DSE does not cause mydriasis in adults without glaucoma. Future studies need to confirm our findings and expand the investigation regarding safety of atropine use during DSE in patients with narrow angle glaucoma.

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Effects of Atropine on Anterior Chamber Depth and Anterior Chamber Inflammation After Primary Trabeculectomy

Cited by 14 publications

References 0 publications

Low‐concentration atropine eyedrops for myopia control in a multi‐racial cohort of Australian children: A randomised clinical trial

Low‐concentration atropine eyedrops for myopia control in a multi‐racial cohort of Australian children: A randomised clinical trial

Post‐trabeculectomy ocular biometric changes

The effect of atropine used in dobutamine stress echocardiography on pupil diameter

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