Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice

Tawa, Masashi; Nakagawa, Keisuke; Ohkita, Mamoru

doi:10.14814/phy2.15755

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…The known "regression to the mean" effect can also have a role. Alongside different adherence to lifestyle advice, different arterial responses to vasodilating stimuli by restoring endothelial function and enhancing NO bioavailability could have brought out this additional finding, as reported by recent experimental and clinical investigations [35][36][37]. Thus, middle-aged pre-hypertensive and non-smoking patients could be the preferable target of this approach based on generic lifestyle advice and nutraceutical supplementation [38].…”

Section: Discussionmentioning

confidence: 95%

The Effects of ESC/ESH-Based Written Generic Lifestyle Advice and a Nutraceutical on 24-Hour Blood Pressure in Patients with High–Normal Office Blood Pressure and Low–Moderate Cardiovascular Risk

Landolfo,

Spannella,

Poliseno

et al. 2023

Nutrients

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(1) Background: Lifestyle changes, eventually coupled with a nutraceutical, are recommended strategies for managing high–normal blood pressure (BP) patients with low–moderate cardiovascular (CV) risk. In a real-life clinical setting, we evaluated the effects of generic written lifestyle advice, extrapolated from the 2018 ESC/ESH guidelines, and a beetroot-based nutraceutical on 24 h BP in a population with a high–normal office BP and low–moderate CV risk. (2) Methods: A longitudinal observational study was conducted in two ESH Hypertension Excellence Centres on 43 consecutive subjects with high–normal BP according to repeated office BP (OBP) measurements and a low–moderate CV risk based on SCORE2/SCORE2-OP. Additionally, 24 h ambulatory BP monitoring (ABPM) was carried out at baseline and three months after lifestyle changes, according to generic written advice from the 2018 ESC/ESH guidelines, coupled with a nutraceutical containing 500 mg of dry beetroot extract. (3) Results: The mean age was 50 ± 11 years, with male prevalence (54%). The prevalence of overweight/obesity was 58%. The mean OBP was 135 ± 3/85 ± 3 mmHg. At baseline, the mean 24 h BP, daytime BP, and night-time BP were 127 ± 7/80 ± 6 mmHg, 131 ± 8/83 ± 6 mmHg, and 118 ± 8/70 ± 5 mmHg, respectively, BP profiles compatible with hypertension status in some subjects. After a median follow-up of 98 (92–121) days, all BPs, except night-time diastolic BP, were significantly decreased: −3 ± 6/−2 ± 4 mmHg for 24 h BP, −3.9 ± 6.0/−3.0 ± 4.0 mmHg for daytime BP, and −3.3 ± 7.4/−1.3 ± 4.7 mmHg for night-time BP, respectively. No significant clinical changes in body weight were detected. BP decreased independently of baseline BP levels, sex, smoking status, and body mass index, while a more substantial BP decrease was observed in older patients. (4) Conclusions: Our exploratory study shows, for the first time, that written generic lifestyle advice taken from the ESC/ESH hypertension guidelines coupled with a beetroot-based nutraceutical may represent a valid initial non-pharmacological approach in subjects with a high–normal office BP and low–moderate CV risk, even without personalized diet interventions.

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Section: Discussionmentioning

confidence: 95%

The Effects of ESC/ESH-Based Written Generic Lifestyle Advice and a Nutraceutical on 24-Hour Blood Pressure in Patients with High–Normal Office Blood Pressure and Low–Moderate Cardiovascular Risk

Landolfo,

Spannella,

Poliseno

et al. 2023

Nutrients

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The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial

Delgado Spicuzza,

Gosalia,

Studinski

et al. 2024

Can. J. Physiol. Pharmacol.

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Postmenopausal cardiovascular health is a critical determinant of longevity. Consumption of beetroot juice (BR) and other nitrate rich foods is a safe, effective non-pharmacological intervention strategy to increase systemic bioavailability of the vasoprotective molecule, nitric oxide (NO), through the exogenous nitrate (NO3-)-nitrite (NO2-)-NO pathway. We hypothesized that a single dose of nitrate-rich beetroot juice (BRnitrate 600 mg NO3- / 140 mL, BRplacebo ~ 0 mg/ 140 mL) would improve resting endothelial function and resistance to ischemia-reperfusion (IR) injury to a greater extent in early- (1-6 years following their final menstrual period (FMP), n=12) compared to late- (6+ years after FMP, n=12) postmenopausal women. Analyses with general linear models revealed a significant (p<0.05) time*treatment interaction effect for brachial artery adjusted FMD. Pairwise comparisons revealed adjusted FMD was significantly lower following IR-injury in comparison to all other time points with BRplacebo (Early FMD 2.51 ± 1.18%, Late FMD 1.30 ± 1.10, p<0.001) and was lower than post-IR with BRnitrate (Early FMD 3.84 ± 1.21%, Late FMD 3.21 ± 1.13 %, p=0.014). Considering the postmenopausal stage-dependent variations in endothelial responsiveness to dietary nitrate at rest and post-IR, we predict differing mechanisms underpin macrovascular protection against IR injury. NCT03644472.

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Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice

Tawa

Nakagawa

Ohkita

2023

Physiological Reports

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This study investigated whether beetroot juice (BRJ) ingestion ameliorates aging-induced functional and structural changes in vasculature. Aged mice (98-100 weeks old) were supplemented with BRJ (nitrate: 3.5 mmol/L) or drinking water for 4 weeks and compared with young mice (12-15 weeks old). The vasorelaxant response of isolated aortas to acetylcholine was markedly weaker in aged mice than in young mice, but the attenuated relaxation was significantly improved in BRJ-supplemented aged mice. The acetylcholine-induced relaxation was completely abolished by N ω -nitro-l-arginine methyl ester in all groups.Additionally, the response to sodium nitroprusside was comparable among the three groups. The aortic medial thickness was significantly greater in aged mice than in young mice, and BRJ supplementation did not suppress this thickening. Plasma nitrate levels were significantly higher in BRJ-supplemented aged mice than in non-supplemented aged mice. Conversely, non-supplemented aged mice had high plasma levels of thiobarbituric acid-reactive substances, but the levels were suppressed in BRJ-supplemented aged mice. These findings suggest that BRJ ingestion improves vascular endothelial dysfunction associated with aging, at least in part, by enhancing nitric oxide bioavailability and reducing oxidative stress. Therefore, beetroot ingestion may be a highly useful self-medication option to prevent vascular aging.

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Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice

Cited by 3 publications

References 53 publications

The Effects of ESC/ESH-Based Written Generic Lifestyle Advice and a Nutraceutical on 24-Hour Blood Pressure in Patients with High–Normal Office Blood Pressure and Low–Moderate Cardiovascular Risk

The Effects of ESC/ESH-Based Written Generic Lifestyle Advice and a Nutraceutical on 24-Hour Blood Pressure in Patients with High–Normal Office Blood Pressure and Low–Moderate Cardiovascular Risk

The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial

Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice

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