Effects of bilateral resection of facial nerves on suckling in developing rats

Fukushima, Nanae; Fujita, Kenya; Yokouchi, Kumiko; Kawagishi, Kyutaro; Moriizumi, Tetsuji

doi:10.1016/j.brainresbull.2003.10.006

Cited by 6 publications

(9 citation statements)

References 9 publications

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“…We confirmed our previous findings indicating that newborn rat pups with bilateral resection of the VII nerve all survived but showed retarded postnatal growth (Fukushima et al, 2004). The present study indicated that unilateral resection of the VII nerve resulted in similar effects to bilateral nerve resection in terms of survival rate, milk intake, and postnatal growth.…”

Section: Discussionsupporting

confidence: 92%

“…From the phylogenetic viewpoint, newborn mammals acquired a completely closed palate separating the nasal and oral cavities, and the perioral muscles migrated from the original neck region of the second pharyngeal arch innervated by the VII cranial nerve (Collins, 1995). We reported that the bilateral VII nerve‐injured newborn rat pups showed decreases in stomach milk weight and body weight (Fukushima et al, 2004). However, effects of unilateral VII nerve injury on breastfeeding remain unsolved.…”

Section: Discussionmentioning

confidence: 99%

“…It has been speculated that the buccolabial musculature (buccinator and orbicularis oris muscles) is essential for breastfeeding by holding the mother's nipple by the action of the orbicularis oris muscle and by creating the intraoral negative pressure by the action of the buccinator muscle, both of which are controlled by the facial (VII) cranial nerve (Collins, 1995; Salmons, 1995). However, we reported recently that the buccolabial muscles play an important role in breastfeeding, but that they are not essential for the survival of newborn rat pups with bilateral VII nerve resection (Fukushima et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

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Effects of hypoglossal and facial nerve injuries on milk‐suckling

Fujita

Yokouchi

Fukuyama

et al. 2005

Intl J of Devlp Neuroscience

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Functional roles of the perioral anatomical structures involved in breastfeeding were examined in newborn rat pups in which the hypoglossal (XII) and facial (VII) nerves had been resected at the neonatal stage. The XII nerve controls tongue movement and is comprised of two functionally distinct branches: the medial branch related to protrusion of the tongue and the lateral branch related to its retraction. Newborn rat pups with bilateral resection of either of the XII nerve components (main trunk: XII-trunk; medial branch: XII-med; lateral branch: XII-lat) failed to suckle milk and did not survive. Unilateral XII nerve-resected neonates showed different milk-suckling capabilities, which thus resulted in differences in survival rate (XII-trunk: 38%; XII-med: 24%; XII-lat: 92%) and postnatal growth during the postnatal 3 weeks until P21. Unilateral and bilateral resections of the VII nerve innervating the buccolabial musculature produced lowered suckling capabilities and retarded postnatal growth, although all pups showed 100% survival. The results indicate a crucial role of the tongue, especially of protruding muscular elements innervated by the XII-med nerve, in breastfeeding. The results also indicate differential effects of the VII and XII nerve components on suckling capability, survival, and postnatal growth of newborn rat pups.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of hypoglossal and facial nerve injuries on milk‐suckling

Fujita

Yokouchi

Fukuyama

et al. 2005

Intl J of Devlp Neuroscience

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“…Effective suckling requires the coordination of muscles and hindbrain cranial nerve systems such as the trigeminal (V), the glossopharyngea (IX) and the vagus (X) nuclei and in particular the hypoglossal (XII) nerve that controls the tongue [21] and the facial (VII) nerve innervating the buccolabial musculature [22,23]. In newborn rats, resection of the XII nerve results in the death due to a failure to suckle milk [24].…”

Section: Motor Outputsmentioning

confidence: 99%

Wired for eating: how is an active feeding circuitry established in the postnatal brain?

Muscatelli

Bouret

2018

Current Opinion in Neurobiology

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From birth, mammals have to find food and maximize caloric intake to ensure growth and survival. Suckling must be initiated quickly after birth and then maintained and controlled until weaning. It is a complex process involving interactions between sensory and motor neuronal pathways. Meanwhile, the control of food intake and energy homeostasis is progressively established via the development of hypothalamic circuits. The development of these circuits is influenced by hormonal and nutritional signals and can be disturbed in a variety of developmental disorders leading to long-term metabolic, behavioral and cognitive dysfunctions. This review summarizes our current knowledge of the neuronal circuits involved in early postnatal feeding processes.

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“…Newborn mammals pass through suckling, transition, and mastication periods involved in their growth (Hall et al, 1975, 1977; Hall and Rosenblatt, 1977; Cramer et al, 1980). Our previous observations regarding the stomach contents of developing Wistar rats at various postnatal (P) ages indicated that rats depend solely on the dam's milk from P0 to P17, both milk and solid food from P18 to P24, and solely on solid food from P25 (Fukushima et al, 2004). Effective suckling and mastication for milk and food intake at each developmental stage are essential for the survival and growth of mammals.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of hypoglossal and facial nerve injuries on survival and growth of rats at different developmental stages

Fukuyama

Yokouchi

Fukushima

et al. 2006

Intl J of Devlp Neuroscience

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The hypoglossal (XII) nerve is made up of functionally different nerve branches: the medial branch related to protrusion of the tongue and the lateral branch related to its retraction. The present study was performed to determine the effects of facial (VII) and XII nerve injuries on the survival and growth of rats in which the unilateral or bilateral VII and XII nerve components (main trunk, XII-trunk; medial branch, XII-med; lateral branch, XII-lat) had been resected at different developmental stages. In the suckling period, unilateral as well as bilateral injuries in the XII-trunk or XII-med nerve produced disturbed milk intake, lower survival rates and growth retardation in the nerve-injured rats. In the transition and mastication periods, only bilateral injury in the XII-trunk or XII-med nerve produced disturbed food intake followed by lower survival rates and growth retardation in those animals. The unilateral XII-lat nerve injury did not have significant effects on milk and food intake, whereas the bilateral injury caused disturbance in milk intake especially at the early neonatal stage. The unilateral VII nerve injury at the early neonatal stage caused deteriorating effects on food intake resulting in lower survival rate and severe growth retardation in the nerve-injured rats. The results indicate that the survival and growth of XII and VII nerve-resected rats differ considerably depending on the nerves injured and the developmental ages of the animals at the time of nerve insult.

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Effects of bilateral resection of facial nerves on suckling in developing rats

Cited by 6 publications

References 9 publications

Effects of hypoglossal and facial nerve injuries on milk‐suckling

Effects of hypoglossal and facial nerve injuries on milk‐suckling

Wired for eating: how is an active feeding circuitry established in the postnatal brain?

Differential effects of hypoglossal and facial nerve injuries on survival and growth of rats at different developmental stages

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