Effects of bisphenol a on hematological, serum biochemical, and histopathological biomarkers in bighead carp (Aristichthys nobilis) under long-term exposure

Akram, Rabia; Iqbal, Rehana; Hussain, Riaz; Ali, Muhammad

doi:10.1007/s11356-021-17329-1

Cited by 17 publications

(10 citation statements)

References 94 publications

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“…The significant change in hematological parameters could also be related to the toxic effect of NFNPs on kidneys. It has been recorded that hematological and biochemical parameter can be used as useful and reliable bioindicators in different animals are wellknown targeted organs of toxicity after exposure to xenobiotic [45]. In contrast to our hematological investigations, an increased percentage of monocyte, total number of white blood cells, and neutrophil percentage have also been reported in rats [62,63].…”

Section: Discussionmentioning

confidence: 63%

“…The hematological profile of each rabbit was determined using an automated hematology analyzer (Sysmex XE-2100, Japan) according to a previous protocol [43,44]. The serum was removed from each blood sample, and different serum biochemical biomarkers of the liver, kidneys, and heart following were measured using commercial kits with the help of a chemistry analyzer [45].…”

Section: Experimental Animal Treatmentmentioning

confidence: 99%

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Hematobiochemical, Oxidative Stress, and Histopathological Mediated Toxicity Induced by Nickel Ferrite (NiFe2O4) Nanoparticles in Rabbits

Khan

Buzdar

Hussain

et al. 2022

Oxidative Medicine and Cellular Longevity

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From the past few decades, attention towards the biological evaluation of nanoparticles (NPs) has increased due to the persistent and extensive application of NPs in various fields, including biomedical science, modern industry, magnetic resonance imaging, and the construction of sensors. Therefore, in the current study, magnetic nickel ferrite (NiFe2O4) nanoparticles (NFNPs) were synthesized and evaluated for their possible adverse effects in rabbits. The crystallinity of the synthesized NFNPs was confirmed using X-ray diffraction (XRD) technique. The saturation magnetization (46.7 emug-1) was measured using vibrating sample magnetometer (VSM) and 0.35-tesla magnetron by magnetic resonance imaging (MRI). The adverse effects of NFNPs on blood biochemistry and histoarchitecture of the liver, kidneys, spleen, brain, and heart of the rabbits were determined. A total of sixteen adult rabbits, healthy and free from any apparent infection, were blindly placed in two groups. The rabbits in group A served as control, while the rabbits in group B received a single dose (via ear vein) of NFNPs for ten days. The blood and visceral tissues were collected from each rabbit at days 5 and 10 of posttreatment. The results on blood and serum biochemistry profile indicated significant variation in hematological and serum biomarkers in NFNP-treated rabbits. The results showed an increased quantity of oxidative stress and depletion of antioxidant enzymes in treated rabbits. Various serum biochemical tests exhibited significantly higher concentrations of different liver function tests, kidney function tests, and cardiac biomarkers. Histopathologically, the liver showed congestion, edema, atrophy, and degeneration of hepatocytes. The kidneys exhibited hemorrhages, atrophy of renal tubule, degeneration, and necrosis of renal tubules, whereas coagulative necrosis, neutrophilic infiltration, and severe myocarditis were seen in different sections of the heart. The brain of the treated rabbits revealed necrosis of neurons, neuron atrophy, and microgliosis. In conclusion, the current study results indicated that the highest concentration of NPs induced adverse effects on multiple tissues of the rabbits.

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Section: Discussionmentioning

confidence: 63%

Section: Experimental Animal Treatmentmentioning

confidence: 99%

Hematobiochemical, Oxidative Stress, and Histopathological Mediated Toxicity Induced by Nickel Ferrite (NiFe2O4) Nanoparticles in Rabbits

Khan

Buzdar

Hussain

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Lipid and protein oxidation is recognized as a major threat to the quality of poultry products. The implication of phytochemicals in the feed or directly in the meat product is a signi cant solution (Akram et al, 2020).…”

Section: Carcass Traitmentioning

confidence: 99%

Assessment of Coriandrum Sativum L., Trigonella Foenum Graecum L., Pimpinella Anisum L., and Their Combinations Effect on Growth Performance, Carcass Trait and Hematobiochemical Parameters in Broiler Chicken

Samira

Messaï

2022

Preprint

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This study has been designed to examine the effects of three phytogenic feed additives (PHT) on certain zootechnical and hematobiochemical parameters in broiler chicken. The PHT were formulated from Coriandrum sativum L., Trigonella foenum-graecum L., and Pimpinella anisum L. 360 one-day-old Cobb broilers were randomly divided into 4 dietary treatment groups; a control group (CTLG), and three groups fed a basal diet supplemented respectively with 3% of Coriander (PHT1G), 3% of a combination 50% Coriander- 50% Fenugreek (PHT2G), and finally 3% of a combination 50% Coriander- 50% Anise (PHT3G). The results showed that the birds of PHT3 group realized the highest live body and internal organs weight. However, the weight of the abdominal fat was not affected. Broilers in the same group had a significantly (P <0.05) higher lymphocyte level 120.103 /µl, followed by PHT2 group with 80.103 /µl. The level of monocytes in PHT2 and PHT3 groups was respectively 66.103 /µl and 60.103 /µl. Concerning the granulocytes, we noted 200.103 /µl in PHT2 group and 102.103 /µl in PHT3G. A significant difference (P <0.05) was recorded in the uric acid levels with 50.4mg/l, 59.84mg/l, and 47.29mg/l respectively for PHT1G, PHT2G, and PHT3G groups. Levels of the uric acid were lower than the level recorded in the control group (84.36mg/l). The use of the phytogenic feed additives we formulated may have a positive effect both on weight gain and hematobiochemical parameters in broiler chicken, especially the levels of different types of white blood cells, and the uric acid rate.

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“…The oxidation of lipids and proteins is recognized as a major threat to the quality of poultry products. The incorporation of phytochemicals into animal feed or directly into meat products is a viable solution [23]. In our study, the significant improvement of carcass parameters could be explained by the stimulatory effects of digestive enzyme secretions, which induce better absorption of nutrients from the digestive tract, such as amino acids [24].…”

Section: Carcass Traitmentioning

confidence: 99%

The effect of spices Coriandrum sativum L., Trigonella foenum-graecum L., Pimpinella anisum L., and their combinations on growth performance, carcass trait, and hematobiochemical parameters in broiler chicken

2022

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Background and Aim: The incorporation of herbs and species has been shown to enrich the food with antioxidants and bioactive antimicrobial compounds, thereby preserving the safety and productivity of broiler chicken production. This study aimed to determine the effects of three phytogenic feed additives (PHT) on certain zootechnical and hematobiochemical parameters in broiler chickens. Coriandrum sativum L. (coriander), Pimpinella anisum L. (green anise), and Trigonella foenum-graecum L. (fenugreek) were used to formulate the PHT. Materials and Methods: A total of 360 1-day-old Cobb broilers for 42 days were randomly assigned to four dietary treatment groups: A control group (CTLG) and three groups fed a basal diet supplemented with 3% of coriander (PHT1G), 3% of a combination 50% coriander-50% fenugreek (PHT2G), and finally, 3% of a combination 50% coriander-50% green anise (PHT3G), respectively, and each experimental group included three repetitions of 30 birds. Zootechnical parameters, carcass productivity, and hematobiochemical properties were measured. Results: The birds in the PHT3G had the greatest body weight and organ weight (p < 0.05). However, the weight of abdominal fat remained unchanged. The same group of broilers had a significantly (p < 0.05) higher lymphocyte level of 120.103/μL, followed by the PHT2G, which had 80.103/μL. The levels of monocytes in the PHT2G and PHT3G were 66.103/μL and 60.103/μL, respectively. Regarding granulocytes, we observed 200.103/μL in the PHT2 group and 102.103/μL in the PHT3G. There was a statistically significant difference (p < 0.05) between the uric acid levels of the PHT1G, PHT2G, and PHT3G, with 50.4 mg/L, 59.84 mg/L, and 47.29 mg/L, respectively. All experimental groups had significantly lower uric acid concentrations than the control group (84.36 mg/L). Conclusion: The use of phytogenic feed additives may positively affect both weight gain and hematobiochemical parameters in broiler chicken, particularly the levels of various white blood cell subtypes and the uric acid rate.

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Effects of bisphenol a on hematological, serum biochemical, and histopathological biomarkers in bighead carp (Aristichthys nobilis) under long-term exposure

Cited by 17 publications

References 94 publications

Hematobiochemical, Oxidative Stress, and Histopathological Mediated Toxicity Induced by Nickel Ferrite (NiFe2O4) Nanoparticles in Rabbits

Hematobiochemical, Oxidative Stress, and Histopathological Mediated Toxicity Induced by Nickel Ferrite (NiFe2O4) Nanoparticles in Rabbits

Assessment of Coriandrum Sativum L., Trigonella Foenum Graecum L., Pimpinella Anisum L., and Their Combinations Effect on Growth Performance, Carcass Trait and Hematobiochemical Parameters in Broiler Chicken

The effect of spices Coriandrum sativum L., Trigonella foenum-graecum L., Pimpinella anisum L., and their combinations on growth performance, carcass trait, and hematobiochemical parameters in broiler chicken

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