Effects of Bushen Tongmai Recipe (补肾通脉方) on protein kinase Bα expression in polycystic ovary rats with insulin resistance

Abstract

BSTMR could improve IR and ovulation dysfunction in PCO rats with IR, and its molecular mechanisms might be closely related with the elevation of mRNA and protein expressions of PKBalpha in target tissues of PCO rats with IR.

Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

“…Bushen Tongmai recipe (composed of Astragalus membranaceus Bge, Radix Polygoni Multiflori, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Puerariae, Herba Epimedii, Rhizoma Chuanxiong, and Radix Rehmanniae) reduced serum fasting insulin and enhanced protein expression of Protein kinase Bα in thecal and granulosa cells of antral follicles ( Li et al., 2010 ). SD rats treated with Changbudodam-Tang (Rhizoma atractylodis, Rhizoma cyperi, Fructus ponciri, Pericarpium citri nobilis, Poria, Arisaematis Rhizoma, Radix glycyrrhizae, Massa Medicata Fermentata, and Zingiberis Rhizoma) and Yongdamsagan-Tang (Radix gentianae, Bupleuri Radix, Alimatis Rhizoma, Lignum akebiae, Plantaginis Semen, Hoelen, Rehmanniae Radix, Angelicae Gigantis Radix, Gardeniae Fructus, Scutellariae Radix, and Radix glycyrrhizae) showed a reduced number of cystic follicles, a higher number of growing secondary follicles, and reduced expression of NGF in ovaries ( Lee et al., 2003 ).…”

“…Herbal medicines were found to normalize female hormones, ( Zangeneh et al., 2010 ; Rezvanfar et al., 2012 ; Jang et al., 2014 ; Yu et al., 2014 ; Gu et al., 2015 ; Zhou et al., 2016 ; Atashpour et al., 2017 ; Sun et al., 2017 ; Xia et al., 2017 ; Zhao et al., 2017 ; Jelodar et al., 2018 ), diminish male hormones ( Yang et al., 2011 ; Rezvanfar et al., 2012 ; Yu et al., 2014 ; Gu et al., 2015 ; Zhou et al., 2016 ; Xia et al., 2017 ; Zhao et al., 2017 ; Jelodar et al., 2018 ), recover the estrous cycle ( Mohamadin et al., 2010 ; Yang et al., 2011 ; Rezvanfar et al., 2012 ; Jang et al., 2014 ; Soumya et al., 2014 ; Yu et al., 2014 ; Gu et al., 2015 ; Lee et al., 2016 ; Zhou et al., 2016 ; Sun et al., 2017 ; Wang et al., 2017 ; Xia et al., 2017 ), ameliorate insulin resistance ( Li et al., 2010 ; Mannerås et al., 2010 ; Yang et al., 2011 ; Desai et al., 2012 ; Wang et al., 2017 ; Zhao et al., 2017 ), and improve lipid metabolism in PCOS model ( Mannerås et al., 2010 ; Desai et al., 2012 ; Soumya et al., 2014 ). The actions of herbal medicines and relevant outcomes are shown in Table 4 .…”