Effects of cadmium on nucleic acid and protein synthesis in rat liver

Stoll, Raymond E.; White, James F.; Miya, Tom S.; Bousquet, William F.

doi:10.1016/s0041-008x(76)80008-7

Cited by 64 publications

(14 citation statements)

References 17 publications

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“…In previous studies it has been mentioned that Cd pretreatment affects the liver regenerative process after PH (17). Our findings are in accordance to those of other investigators (18,19). Cihak and Inoue observed a decrease of DNA synthesis and TK activity in Cd-treated rats 24 hr after PH (18).…”

Section: Discussionsupporting

confidence: 93%

“…Cihak and Inoue observed a decrease of DNA synthesis and TK activity in Cd-treated rats 24 hr after PH (18). Stoll et al have also reported that DNA synthesis was decreased 20 hr after PH in Cd-treated rats (19). In these studies Cd was administered simultaneously (18) or 1 hr after PH (19) and DNA synthesis was estimated at one time point only.…”

Section: Discussionmentioning

confidence: 95%

“…Stoll et al have also reported that DNA synthesis was decreased 20 hr after PH in Cd-treated rats (19). In these studies Cd was administered simultaneously (18) or 1 hr after PH (19) and DNA synthesis was estimated at one time point only. In our study Cd was administered either prior or simultaneously to PH and the effect of Cd on 3HTdR incorporation and TK activity was examined at different time points up to 96 hr.…”

Section: Discussionmentioning

confidence: 95%

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Effect of cadmium on liver regeneration after partial hepatectomy in rats.

Margeli

Theocharis

Skaltsas

et al. 1994

Environ Health Perspect

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Cadmium is a nonabundant element that is widely distributed throughout the biosphere and its toxic effects are becoming potentially more serious due to industrialization. It has been reported that cadmium might interact with nucleic acid biosynthesis. In this study we examined the effect of cadmium administration, either 24 hr before or simultaneously to partial hepatectomy, on the liver regenerative process in rats, at different time intervals. The rate of DNA synthesis was suppressed markedly in the cadmium pretreated group and the first peak of liver regeneration was delayed, compared to the simply partially hepatectomized one. The administration of cadmium simultaneously to partial hepatectomy, caused a marked decrease of the rate of DNA biosynthesis, compared to the pretreatment.The rate-determining enzyme thymidine kinase was suppressed in the liver of both cadmium-treated groups. Biochemical parameters and histological findings were also coestimated. The above data suggest that either preor simultaneous administration of cadmium, suppressed the liver regenerative process, probably due to the inhibition of thymidine kinase. -Environ Health Perspect 102(Suppl 3): 273-276 (1994).

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

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Effect of cadmium on liver regeneration after partial hepatectomy in rats.

Margeli

Theocharis

Skaltsas

et al. 1994

Environ Health Perspect

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“…In the liver of rats receiving 18 pmol Cd2+/kg, we have observed a significant increase in elongation factor activity after 1-2 days [Rakhra and Nicholls. unpublished observations] which correlates with the reported increase in hepatic metallothionein synthesis. Similarly, in whole-cell stud ies of liver an increase in synthesis of protein was reported [21], However, when different liver proteins were examined, some exhibited increased syn thesis and others decreased synthesis [22], while ribosome preparations were of decreased activity in vitro [23][24][25]. Thus, transcriptional and trans lational changes other than those associated with metallothionein mRNA translation appear to be involved in liver as well as testes and kidney during the acute response to 'subtoxic' levels of Cd2+.…”

Section: Discussionmentioning

confidence: 92%

Testicular Protein Synthesis during the Response to Subtoxic Levels of Cadmium

Dm¹,

Gs²

1981

Horm Res

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Male rats received one injection of a ‘subtoxic’ amount of Cd²⁺ (9.2 µmol/kg body weight) as cadmium chloride and the testes were removed 24 h later. Homogenate fractions of testes that had been freed of ribosomes were tested for their activity in cell-free protein-synthesizing systems using excess exogenous rat liver ribosomes and mRNA. A marked decrease in the incorporation of free [¹⁴C]-phenylalanine into peptide was observed with the testes preparations from the cadmium-treated rats. The results indicated that about half of the effect of cadmium was due to decreased aminoacyl-tRNA synthetase activity and the other half was due to decreased binding of [¹⁴C]-phenylalanyl-tRNA to ribosomes. The results are discussed relative to the contrasting results obtained in kidney and liver preparations.

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“…The effect of cadmium on RNA synthesis in vivo is biphasic with time and doses, with an initial increase of incorporation of 14C-orotic acid into RNA. In partially hepatectomized rats cadmium inhibits DNA synthesis (Stoll et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Effects of Cadmium on Polyribosome Sedimentation Pattern in Mouse Liver

Car¹,

Naranscik²,

Gamulin³

1979

Pathobiology

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Cadmium injected to mice provokes an acute disaggregation of hepatic polyribosomes. The effect appears within 15 min, it is maximal after 1 h and then gradually disappears. The reaggregation of polyribosomes takes place 6–12 h after injection. The disaggregation of polyribosomes is linear with log doses in a range of 7.25–20 µmol/kg CdCl₂. Cycloheximide pretreatment prevents the disaggregation of polyribosomes in the livers of cadmium-treated mice.

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Effects of cadmium on nucleic acid and protein synthesis in rat liver

Cited by 64 publications

References 17 publications

Effect of cadmium on liver regeneration after partial hepatectomy in rats.

Effect of cadmium on liver regeneration after partial hepatectomy in rats.

Testicular Protein Synthesis during the Response to Subtoxic Levels of Cadmium

Effects of Cadmium on Polyribosome Sedimentation Pattern in Mouse Liver

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