Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes

Abstract

Tumor necrosis factor-alpha was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

“…Ferulic acid was also shown to reduce blood glucose concentrations in KK-A y mice (21), C57BL/KsJ-db/db mice (22), and streptozotocin-induced diabetic mice (21) and rats (23). Caffeic acid and cinnamic acid, metabolites of chrologenic acids, were shown to improve the tyrosine phosphorylation of IR in the FL83B insulin-resistant hepatocyte cell line (24). Therefore, in a future study, we need to investigate the effect of caffeine and the mentioned compounds in insulin signaling and to examine whether or not this effect is identical to that of coffee.…”

Effect of Phenolic Acid on Antioxidant Activity of Wine and Inhibition of Pectin Methyl Esterase

“…Lee et al 21 have investigated the antioxidant action mechanism of p-coumaric acid in stressed bovine aortic endothelial cells and revealed that pretreatment with p-coumaric acid causes an induction of peroxidase and prevents lipid peroxidation and cell death caused by high glucose plus arachidonic acid exposure. Caffeic acid and cinnamic acid are reported to promote the insulin receptor tyrosyl phosphorylation, which upregulates the expression of the insulin signal associated proteins, increases the uptake of glucose, and alleviates insulin resistance in cells as a consequence 17 . Although plant phenolic compounds display antioxidant effects in biological systems, the action mechanism remains controversial.…”

Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting

“…A family of GLUT isoforms named GLUT1-7 have been gradually discovered. 10,11 GLUT1 and GLUT3 are predominant GLUTs on the human BBB. GLUT1 is highly expressed on the membrane of BCECs and responsible for stereoselectively transporting the D-glucose enantiomer into the extracellular space of the brain.…”