Effects of Calcium-Vitamin D and Calcium-Alone on Pain Intensity and Menstrual Blood Loss in Women with Primary Dysmenorrhea: A Randomized Controlled Trial

Zarei, Somayeh; Mohammad‐Alizadeh‐Charandabi, Sakineh; Mirghafourvand, Mojgan; Javadzadeh, Yousef; Effati-Daryani, Fatemeh

doi:10.1093/pm/pnw121

Cited by 42 publications

(49 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Women with primary dysmenorrhea who use non-steroidal anti-inflammatory drugs are suggested to use natural antioxidants such as vitamin E, vitamin C, and β-carotenoids for the reduction of pain [7,53]. Single randomized controlled trials showed the effect of vitamin supplements on the reduction of menstrual pain reduction [63,66,67], but a Cochrane meta-analysis on the effect of dietary supplements for primary dysmenorrhea lacked high quality evidence to support the effectiveness and safety of any dietary supplement for dysmenorrhea. Therefore, more research with higher methodological qualities are required [24].…”

Section: Discussionmentioning

confidence: 99%

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies

Bajalan

Alimoradi

Moafi

2019

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background: The incidence and severity of primary dysmenorrhea are influenced by various factors. The aim of the present study was to review nutritional factors influencing primary dysmenorrhea. Methods: Academic databases including Web of Science, EMBASE, Scopus, and PubMed (including Medline) were searched using keywords of nutrition, diet, and primary dysmenorrhea. In this study, observational studies that were published in English from 1990 to April 2018, which focused on nutritional factors affecting primary dysmenorrhea, were selected. The evaluation of studies was performed using a modified STROBE checklist with 10 items. Results: Out of 5,814 retrieved studies, 38 articles met inclusion criteria and were included for final data synthesis. The increased consumption of fruits and vegetables as the sources of vitamins and minerals, as well as fish and milk and dairy products have positive associations with less menstrual pain. Inconsistent results were reported on the consumption of other nutritional groups. Studies showed negative associations of meal skipping and following diet to lose weight with severity of dysmenorrhea. Conclusion: A few studies showed inconclusive findings due to methodological heterogeneities for assessing nutritional habits and different methods of measuring dysmenorrhea pain. Therefore, further analysis and future interventional studies with stronger methodologies are required.

show abstract

Section: Discussionmentioning

confidence: 99%

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies

Bajalan

Alimoradi

Moafi

2019

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Efek yang ditimbulkan antara lain mual, dispepsia, ulkus, peptik dan diare. Oleh karena itu banyak penelitian mencari alternative yang tepat dan dalam mengurangi intensitas nyeri akibat dismenore primer dibandingkan dengan mengonsumsi kombinasi suplemen dari kalsium dan vitamin D [9] .…”

Section: Intensitas Nyeri Dismenore Primer Sebelum Diberikan Susu Sapunclassified

“…Akibatnya aliran darah menuju ke rahim berkurang saat menstruasi sehingga menyebabkan nyeri [6] . Sedangkan menurut Zarei et al (2017) kalsium mampu mengatur kemampuan sel otot dalam menerima rangsangan saraf, dan bisa dianggap sebagai stabilizer [9] . Defisiensi kalsium juga dapat menyebabkan peningkatan nyeri dan gejala pra-mesntruasi.…”

Section: Intensitas Nyeri Dismenore Primer Sebelum Diberikan Susu Sapunclassified

“…Menurut Lavon Dunne dalam Nutrition Almanac pada tahun 2002, untuk dapat menurunkan nyeri saat dismenore diperlukan kalsium sejumlah 800-1.000 mg, dengan cara dikonsumsi sebanyak 250-500 mg setiap 4 jam sekali saat merasakan nyeri [8] . Sedangkan menurut penelitian lain menyatakan dengan mengonsumsi suplementasi kalsium sebanyak 1.000 mg per hari terbukti efektif dalam mengurangi intensitas nyeri akibat dismenore primer dibandingkan dengan mengonsumsi kombinasi suplemen dari kalsium dan vitamin D [9] . Para peneliti meyakini bahwa kalsium memainkan peran dalam mengurangi rasa sakit saat dismenore dengan mengontrol aktifitas neuromuscular pada rahim akibat prostaglandin yang berlebihan.…”

unclassified

See 1 more Smart Citation

Pengaruh Konsumsi Susu Sapi Terhadap Penurunan Intensitas Nyeri Dismenore Primer Pada Siswi Jurusan Keperawatan Di SMKN 2 Malang

Febriani

Ariani²,

Kusumastuty³

2018

JOIM

View full text Add to dashboard Cite

Primary dysmenorrhea is a common gynecological disorder among adolescents females without pathological abnormalities. Primary dysmenorrhea usually begins two days before menstruation or during menstruation and lasts up to 48-72 hours. This is due to high levels of prostaglandins that cause contraction in the myometrium. The incidence of dysmenorrhea in Indonesia is 64.25%, which 54.89% has primary dysmenorrhea while 9.36% has secondary dysmenorrhea. In principle there are two therapies for treatment of primary dysmenorrhea that is pharmacological and non-pharmacological. Cow milk is a food that containing high calcium and can be used as one of the non-pharmacological therapy to reduce pain intensity of primary dysmenorrhea. This study aims to determine the influence of cow milk consumption to decrease the pain intensity of primary dysmenorrhea in students of nursing department at SMKN 2 Malang. The research design used was true experiment with pre test-post test with control group design. The sample in this study were 21 people and divided into three groups taken by simple random sampling. The results showed that there was a difference of decrease pain intensity in three groups using One Way Anova test with p value 0.000 (p <0.005). The optimal dose can decrease pain intensity of primary dysmenorrhea is cow milk with 1000 mg calcium which has the highest pain delta value of 4.57 compared with experimental group II and control group. So it can be concluded that the higher value of the delta pain then the greater the dose effect given to decreased pain intensity of primary dysmenorrhea. ABSTRAKDismenore primer merupakan gangguan ginekologi yang umumnya terjadi pada remaja putri tanpa ditemukan adanya kondisi patologi. Rasa sakit dari dismenore primer biasanya dimulai dua hari sebelum menstruasi atau saat menstruasi dan bertahan hingga 48-72 jam. Hal ini disebabkan karena tingginya kadar prostaglandin yang menyebabkan

show abstract

“…According to some studies, the role of vitamin D deficiency in the development of menstrual disorders in women was considered to be proven; therefore, in these disorders, high-dose vitamin D had to be administered [2]. However, according to other authors, the level of vitamin D (in combination with calcium) was of no clinical significance and a positive correlation with the function of the reproductive organs was not found [3]. A direct correlation between vitamin D levels and metabolic and hormonal disorders, such as insulin resistance, an increase in serum total testosterone and dehydroepiandrosterone (DHEA) was shown.…”

Section: Introductionmentioning

confidence: 99%

Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

Bashmakova

Lisovskaya

Vlasova

2017

Gynecological Endocrinology

View full text Add to dashboard Cite

In the literature review, 50 scientific sources surrounding the problem of vitamin D deficiency, 80% of which amounted to the issuance of the last 5 years, have been analyzed. Despite the impact of vitamin D deficiency on the health of children and adolescents has been studied for a long time, the information on the role of vitamin D in the formation of menstrual function in pubertal girls is scant and ambiguous. Among the hypotheses of menstrual dysfunction with vitamin D deficiency, neurohumoral regulation of the hypothalamic-pituitary-ovarian system is considered to be essential due to the localization of vitamin D receptors (VDR), unlike other vitamins, in the nuclei of various tissues and organs. However, in the last 10 years, data on the role of genetic polymorphism of the VDR gene in the pathogenesis of various manifestations of menstrual dysfunction have been accumulated. Some studies indicated a beneficial effect of cholecalciferol on such menstrual dysfunctions as oligomenorrhea and dysmenorrhea. Regarding numerous data on the role of vitamin D, both traditional and recently published, there is a strong correlation between vitamin D deficiency and other various factors, determining a wide range of polymorphic clinical manifestations where menstrual dysfunction is essential in girls at the age of puberty. ARTICLE HISTORY

show abstract

Effects of Calcium-Vitamin D and Calcium-Alone on Pain Intensity and Menstrual Blood Loss in Women with Primary Dysmenorrhea: A Randomized Controlled Trial

Abstract: This study was approved by the Ethics committee of Tabriz University of Medical Sciences (code 92145) and registered at the Iranian Registry of Clinical Trials with IRCT201402043706N21.

Cited by 42 publications

References 25 publications

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies

Pengaruh Konsumsi Susu Sapi Terhadap Penurunan Intensitas Nyeri Dismenore Primer Pada Siswi Jurusan Keperawatan Di SMKN 2 Malang

Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review

Contact Info

Product

Resources

About