Effects of carbon dioxide pneumoperitoneum on hepatic function in obstructive jaundice: an experimental study in a rat model

Bostancı, Erdal Birol; Yol, Sinan; Teke, Zafer; Kayaalp, Cüneyt; Sakaoğulları, Zişan; Turkcu, Ummuhani Ozel; Bi̇lgi̇han, Ayşe; Akoğlu, Musa

doi:10.1007/s00423-009-0577-6

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…Numerous experimental studies proved more intense oxidative stress and increased intensity of lipid peroxidation in the plasma and liver tissue in animals with experimentally induced cholestasis [6][7] .…”

Section: Introductionmentioning

confidence: 99%

Correlation of inflammation parameters and biochemical markers of cholestasis with the intensity of lipid peroxidation in patients with choledocholithiasis

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Correlation of inflammation parameters and biochemical markers of cholestasis with the intensity of lipid peroxidation in patients with choledocholithiasis

et al. 2013

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“…Interestingly, decreases in RBF and GFR are among the most common pathophysiological alterations in clinical and experimental jaundice and cirrhosis [46,47,86], suggesting that these clinical conditions may display an exaggerated renal vulnerability to increased IAP. In this context, Bostanci et al [87] have demonstrated that 12 mmHg pneumoperitoneum for 60 min in a rat model of obstructive jaundice resulted in moderate but nonsignificant increases in serum liver enzymes including AST, ALT, and total bilirubin values. However, this report did not refer to the renal effects of increased IAP in rats with obstructive jaundice.…”

Section: Pneumoperitoneum and Kidney Functionmentioning

confidence: 99%

Deleterious Effects of Increased Intra-Abdominal Pressure on Kidney Function

Armaly

Abassi

2014

Advances in Nephrology

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Elevated intra-abdominal pressure (IAP) occurs in many clinical settings, including sepsis, severe acute pancreatitis, acute decompensated heart failure, hepatorenal syndrome, resuscitation with large volume, mechanical ventilation with high intrathoracic pressure, major burns, and acidosis. Although increased IAP affects several vital organs, the kidney is very susceptible to the adverse effects of elevated IAP. Kidney dysfunction is among the earliest physiological consequences of increased IAP. In the last two decades, laparoscopic surgery is rapidly replacing the open approach in many areas of surgery. Although it is superior at many aspects, laparoscopic surgery involves elevation of IAP, due to abdominal insufflation with carbonic dioxide (pneumoperitoneum). The latter has been shown to cause several deleterious effects where the most recognized one is impairment of kidney function as expressed by oliguria and reduced glomerular filtration rate (GFR) and renal blood flow (RBF). Despite much research in this field, the systemic physiologic consequences of elevated IAP of various etiologies and the mechanisms underlying its adverse effects on kidney excretory function and renal hemodynamics are not fully understood. The current review summarizes the reported adverse renal effects of increased IAP in edematous clinical settings and during laparoscopic surgery. In addition, it provides new insights into potential mechanisms underlying this phenomenon and therapeutic approaches to encounter renal complications of elevated IAP.

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“…The main advantages of this method include lower hospitalization duration, small incisions made during the surgery, fewer complications, and shorter recovery periods for the patients (1)(2)(3). According to the studies, the incidence of complications after laparotomic cholecystectomy is reported 5-17% (3,4,5), while it is decreased to 2-10% in the laparoscopic approach (1,2). Considering the mentioned advantages, laparotomic cholecystectomy is now approved as the gold standard treatment for symptomatic gallstone (1).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Liver Function Tests and Serum Bilirubin Levels After Laparoscopic Cholecystectomy

Maleknia

Ebrahimi

2020

Med Arch

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Introduction: Laparoscopic cholecystectomy has been known as one of the most important prevalent and minimally invasive surgeries in medicine. Aim: The aim here was to investigate the changes in liver enzymes and bilirubin levels after laparoscopic cholecystectomy in patients diagnosed with chronic cholecystitis. Methods: This cross-sectional study was conducted at Poursina Hospital (Rasht, Iran) and 128 patients who met both inclusion and exclusion criteria were enrolled for further investigations. After collecting the patients' bio-demographic information, levels of serum alkaline phosphatase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, and bilirubin were checked before laparoscopic cholecystectomy and 24 (post-op 1) and 48 (post-op 2) h after laparoscopic cholecystectomy. Results: No significant difference was found in the serum levels of ALP in post-op 1 and 2 compared both to each other and to the baseline (P>0.05). Regarding AST and ALT, there was a significant increase in post-op 1 and 2 compared to their baseline values (P<0.05). However, the difference between post-op 1 and post-op 2 was not significant for these outcomes.Compared to baseline levels, LDH had a significant increase after post-op 2 (P=0.001); but not after post-op 1 (P >0.05). Moreover, total bilirubin levels showed significant increases at post-op 1 and post-op 2 from the baseline and also in comparison with each other (P < 0.05). Conclusion:Our results demonstrated a transient increase in liver function tests and bilirubin after laparoscopic cholecystectomy.

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Effects of carbon dioxide pneumoperitoneum on hepatic function in obstructive jaundice: an experimental study in a rat model

Cited by 6 publications

References 55 publications

Correlation of inflammation parameters and biochemical markers of cholestasis with the intensity of lipid peroxidation in patients with choledocholithiasis

Correlation of inflammation parameters and biochemical markers of cholestasis with the intensity of lipid peroxidation in patients with choledocholithiasis

Deleterious Effects of Increased Intra-Abdominal Pressure on Kidney Function

Evaluation of Liver Function Tests and Serum Bilirubin Levels After Laparoscopic Cholecystectomy

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