Effects of carcinogenic agents on aquatic animals: An environmental and experimental overview

Carcinogens and Cancers in Freshwater Fishes

“…This idea is supported mostly by circumstantial evidence (1)(2)(3)(4)(5). There is, however, a growing body offield-related, laboratory-generated data, which also supports a link between certain kinds of aquatic pollution and cancer in fish (6)(7)(8)(9)(10).…”

Neoplasia in Zebrafish (Danio rerio) Treated with 7,12-Diniethylbenz[a]anthracene by Two Exposure Routes at Different Developmental Stages

“…Dietary exposure of rainbow trout to DMBA at 750 ppm for 7 weeks, beginning at 9 weeks of age, can yield over 80% incidence of gastric neoplasia and lesser incidences of liver and gas bladder neoplasia (20). In zebrafish, a maximal incidence of 18°/0 of fish developed neoplasia after receiving 1 (7,12,25). Furthermore, exposure protocols differed between species, and carcinogen uptake has not been measured in these studies.…”

Carcinogenicity of Black Rock Harbor Sediment to the Eastern Oyster and Trophic Transfer of Black Rock Harbor Carcinogens from the Blue Mussel to the Winter Flounder

“…Much ofthe literature can be found in the following proceedings, reviews and selected research papers (26,(29)(30)(31)(32)(33)(34)(35)(36)(37). Reviewers also note that molluscan neoplasms are predominandy ofhemic origin and that the evidence favors a viral rather than a chemical etiology.…”